DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and dmbx1a

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_694509.1	Gene:	dmbx1a / 142987	ZFINID:	ZDB-GENE-020117-1	Length:	388	Species:	Danio rerio

Alignment Length:	370	Identity:	76/370 - (20%)
Similarity:	126/370 - (34%)	Gaps:	102/370 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1615 HSEQSSQSASQSYN------QQPERITEQR--VGNLNIQQR-----EQSSQLQQQAQSQTQSQTR 1666
            :|..:..|.|..||      ||.:...:.|  |..|.:.:|     .|...|:.:..||.:.|.|
Zfish     9 YSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRR 73

  Fly  1667 SQVGNT--QIERRRKVTEEFERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQA---------- 1719
            |:...|  |:|...|.   |::|.....:        :.:..|...::.:|:.|.
Zfish    74 SRTAFTAQQLEALEKT---FQKTHYPDVV--------MRERLAMCTNLPEARVQVWFKNRRAKFR 127

  Fly  1720 -QSQSQNQSDTERRSSYGKTGFVAS----QAKRLSCMEEEISSLTSQSQAISARAS--ALGEGCF 1777
             :.:|..:...:::......|.:|:    :|.....:|.:..|.||.|.::.|.|:  |||.
Zfish   128 KKQRSLQKEQLQKQKDVSTDGALAASDKDEAPSTLNLENQPPSSTSSSSSMEAEAAPHALGS--- 189

  Fly  1778 PNLRSPTFDSKFPLKPAPAESIVPGYATVPAAT-------------KMLTAPPPGFLQQQQQQQQ 1829
                    :....|....||......||...||             |:...|.||.|....::..
Zfish   190 --------ELSVELNVTSAEQSGSESATEDNATDKEEEIKQHREDLKVEKEPAPGNLSPLCKRLS 246

  Fly  1830 RSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVARSSQSLTQASAITTTTNNQAT 1894
                   ....|.:...:.:|||...|..:|.|.:.:|:..|:.|..:...|..|.|.
Zfish   247 -------PKPDSPLGSPAISSSSSGVTGGISQSHSYSSSPLSLFRLQEQFRQHMAATN------- 297

  Fly  1895 TAYRSSNGSITKPNLASRPSIASITAPGS-------ASAPAPVPS 1932
                         ||...||. .:..|.|       .:.|||:.|
Zfish   298 -------------NLVHYPSF-DMATPSSIPYLGMNVNMPAPLGS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
dmbx1a	NP_694509.1	Homeobox	74..127	CDD:278475	10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..272		32/160 (20%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	365..378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030