DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp52 and DMBX1

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001374705.1	Gene:	DMBX1 / 127343	HGNCID:	19026	Length:	382	Species:	Homo sapiens

Alignment Length:	391	Identity:	86/391 - (21%)
Similarity:	135/391 - (34%)	Gaps:	112/391 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1615 HSEQSSQSASQSYN------QQPERITEQR--VGNLNIQQR-----EQSSQLQQQAQSQTQSQTR 1666
            :|..:..|.|..||      ||.:...:.|  |..|.:.:|     .|...|:.:..||.:.|.|
Human     9 YSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRR 73

  Fly  1667 SQVGNT--QIERRRKVTEEFERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQA---------- 1719
            |:...|  |:|...|.   |::|.....:        :.:..|...::.:|:.|.
Human    74 SRTAFTAQQLEALEKT---FQKTHYPDVV--------MRERLAMCTNLPEARVQVWFKNRRAKFR 127

  Fly  1720 -------QSQSQNQSDTERRSSYGK-------TGFVASQAKRLSCME---EEISSLTSQSQAISA 1767
                   :.|.|.|.:.|.....||       |.....|..||...:   |...||:.||.:.||
Human   128 KKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESA 192

  Fly  1768 -----------RASA-------------LGEGCFPNLRSPTFDSKFPLKPAPAESIVPGYATVPA 1808
                       ||.|             .|.||  ...||..||...|...|   :.||...:..
Human   193 PEDQPDREEDPRAGAEDPKAEKSPGADSKGLGC--KRGSPKADSPGSLTITP---VAPGGGLLGP 252

  Fly  1809 ATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVA 1873
            :....::|...|..|:|.:|..:      ||.:.|..|||.....|        .|:|:|:|:|.
Human   253 SHSYSSSPLSLFRLQEQFRQHMA------ATNNLVHYSSFEVGGPA--------PAAAAAAAAVP 303

  Fly  1874 RSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRPSIASITAPGSASAPAPVPSAAPTKA 1938
            ....::....::...:..|:.:|..:::..:.                ||...|||....||..|
Human   304 YLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVW----------------GSPLLPAPPAGLAPASA 352

  Fly  1939 T 1939
            |
Human   353 T 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
DMBX1	NP_001374705.1	Interaction with OTX2 and is required for repressor activity. /evidence=ECO:0000250\|UniProtKB:Q91ZK4	1..156		33/157 (21%)
		Homeobox	74..128	CDD:395001	10/64 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..252		31/128 (24%)
		OAR	357..373	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	359..372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030