DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Pdlim3

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_446102.2	Gene:	Pdlim3 / 114108	RGDID:	620427	Length:	364	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	113/393 - (28%)
Similarity:	164/393 - (41%)	Gaps:	97/393 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||.|||::.::..||.:|.|.|.|||.::.|:.....::.|.||||.:..:....
  Rat    12 PWGFRLSGGIDFNQPLVITRITPGSKAEAANLCPGDVILAIDGFGTESMTHADAQDRIKAASYQL 76

  Fly    83 VITVQRGGS-TWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPF-----S 141
            .:.:.|..: .|.|.|:..|..    .|:     |.:|..:.||..:....:|...:||     :
  Rat    77 CLKIDRAETRLWSPQVSEDGKA----HPF-----KINLEAEPQDVNYFEHKHNIRPKPFIIPGRT 132

  Fly   142 NG---------GDG-----------------------------------GVKSIVNKQYNTPVGI 162
            :|         |.|                                   ||| ||:.|:|||:.:
  Rat   133 SGCSTPSGIDCGSGRSTPSSVSTVSTICPGDLKVAAKMAPNIPLEMELPGVK-IVHAQFNTPMQL 196

  Fly   163 YSDESIAETLSAQAEVLAGGVLGVNFKKNEKEYQGDRSEVLKFLREEETGQSTPAFGNSHYEHDA 227
            |||::|.|||..|.....|....::........|.|...:|...|:|      ||         |
  Rat   197 YSDDNIMETLQGQVSTALGETPSMSEPTASVPPQSDVYRMLHDNRDE------PA---------A 246

  Fly   228 PQQ---LQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTGGLPTGQN--ICTECER 287
            |:|   .:..|:..|        .....:.:.||.|.|||....    ||....|.  :|.:|..
  Rat   247 PRQSGSFRVLQELVN--------DGSDDRPAGTRSVRAPVTKVH----GGAGGAQRMPLCDKCGS 299

  Fly   288 LITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQAAINNPPTGTEGYVPVP 352
            .|.|..|:.:||..|.|||.||.|..:||.:||:....:|||::||:  |...||   |||..|.
  Rat   300 GIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFVEGELYCEMHAR--ARTRPP---EGYDTVT 359

  Fly   353 IKP 355
            :.|
  Rat   360 LYP 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	27/68 (40%)
		DUF4749	150..>217	CDD:292558	20/66 (30%)
		LIM_ALP_like	282..333	CDD:188746	21/50 (42%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Pdlim3	NP_446102.2	PDZ_signaling	2..80	CDD:238492	27/67 (40%)
		DUF4749	184..263	CDD:406377	28/102 (27%)
		LIM_ALP	294..346	CDD:188834	22/51 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10028
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910