DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and LDB3

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001165081.1	Gene:	LDB3 / 11155	HGNCID:	15710	Length:	732	Species:	Homo sapiens

Alignment Length:	871	Identity:	235/871 - (26%)
Similarity:	340/871 - (39%)	Gaps:	219/871 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1376 FPPPSPLSHLTKQGKAVQSGLHKADSIPKYQ----RNWTVLPTQSPIRTPEPQELRENVPLAFVD 1436
            |..|..:|.:|...||.||.|.:.|.:....    ...|.|..|:.|::..     .|:.|. :.
Human    23 FNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSAS-----YNLSLT-LQ 81

  Fly  1437 APKAPVTSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQPLDELV 1501
            ..|.|:         ||:..|.|.....|....:|:  |.|       |.:|.: :|..|
Human    82 KSKRPI---------PISTTAPPVQTPLPVIPHQKD--PAL-------DTNGSL-VAPSP----- 122

  Fly  1502 RPDQALTPTRPYTPSL--TNKPAPIVPFYQTEEKLVFEECSATHARNYNELNASPFPDRTRSPAP 1564
            .|:...:|..|.||.|  |..||             |...||             |.....:..|
Human   123 SPEARASPGTPGTPELRPTFSPA-------------FSRPSA-------------FSSLAEASDP 161

  Fly  1565 GPPPNPLNAIRAPRMKEPETKSNILSVSGGPRLQTGSITTGQSYQGQLLAHSEQSSQSASQSYNQ 1629
            |||...|.|     ...||...::|    ||:...|| :..:.|...:..:|.::.:..:|.| |
Human   162 GPPRASLRA-----KTSPEGARDLL----GPKALPGS-SQPRQYNNPIGLYSAETLREMAQMY-Q 215

  Fly  1630 QPERITEQRV---GNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQIERRRKVTEEFERTQSAK 1691
            ...|.....|   |..:.|:|...|.|:..|.|                             :.|
Human   216 MSLRGKASGVGLPGGADYQERFNPSALKDSALS-----------------------------THK 251

  Fly  1692 TIEIR--TGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQAKRLSCMEEE 1754
            .||::  .|..::..        :|..|.....||:                       :.|:
Human   252 PIEVKGLGGKATIIH--------AQYNTPISMYSQD-----------------------AIMD-- 283

  Fly  1755 ISSLTSQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPAESIVPGY-ATVPAATK------- 1811
                     ||:.:|.|.|.         .|....|:|....:|..|.| |.:.:..|
Human   284 ---------AIAGQAQAQGS---------DFSGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADE 330

  Fly  1812 -------------MLTAPPPG--FLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSS 1861
                         .:.|...|  |:|...::..|.:    :...||...:..|||:.||.:|.|.
Human   331 WARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRS----RPQASSYSPAVAASSAPATHTSYSE 391

  Fly  1862 SSASASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPN-LASRPSIASITAPGSAS 1925
            ..|:.:....|      :|.||...:.......:.|..|.|:...|. ....|:.|...:|..|.
Human   392 GPAAPAPKPRV------VTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAY 450

  Fly  1926 APAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKS 1990
            .|:|||:..|:.|.|...:|....:...:...:..|..||..||.::|.:.:...     |.|||
Human   451 TPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKF-----APGKS 510

  Fly  1991 AGAFGATSAPKRGRGILNKAAGPGV------------------RIPLCNSCNVQIRGPFITALGR 2037
            ..:....:.|:.|...  ..|||.|                  |.|||..||..|||||:.|:||
Human   511 TTSISKQTLPRGGPAY--TPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGR 573

  Fly  2038 IWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHP 2102
            .|.|:.|.|  ..|:..|.|:.||||:.::|||.|:|::.||.|:||..||.|:.::|:.:.:|.
Human   574 SWHPEEFTC--AYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHT 636

  Fly  2103 ECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFN 2167
            .||.|..|.|.|||..|.:|||..|||.|:..||:|||..|.|||||||:::|||.|.:|..||.
Human   637 TCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFI 701

  Fly  2168 CTFCKQNLEGQSFYNKGGRPFCKNHA 2193
            |..|..|||||.||:|..||.||.||
Human   702 CAVCHVNLEGQPFYSKKDRPLCKKHA 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	25/52 (48%)
		LIM	2081..2132	CDD:259829	23/50 (46%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	30/52 (58%)
LDB3	NP_001165081.1	PDZ_signaling	5..81	CDD:238492	16/63 (25%)
		DUF4045	<77..180	CDD:330572	36/158 (23%)
		ZM	189..214	CDD:128974	4/25 (16%)
		DUF4749	263..353	CDD:318205	20/140 (14%)
		Atrophin-1	<387..554	CDD:331285	40/179 (22%)
		LIM1_ZASP_Cypher	556..607	CDD:188838	25/52 (48%)
		LIM2_Enigma_like	615..666	CDD:188748	23/50 (46%)
		LIM3_Enigma_like	674..727	CDD:188749	30/52 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8783
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm41228
orthoMCL	1	0.900	-	-		OOG6_109269
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.810