DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and PDLIM5

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001243355.2	Gene:	PDLIM5 / 10611	HGNCID:	17468	Length:	625	Species:	Homo sapiens

Alignment Length:	682	Identity:	195/682 - (28%)
Similarity:	293/682 - (42%)	Gaps:	124/682 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1565 GPPPNPLNAIRAPRMKEPETKSNILSVSGGPRLQT----GSIT---TGQSYQGQLLAHSEQSSQS 1622
            ||.|.............|.|.|::  ..||...|.    |.:.   .|.:.||.....::...:.
Human    10 GPAPWGFRLQGGKDFNMPLTISSL--KDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKG 72

  Fly  1623 ASQSYNQ---------QPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQIER-- 1676
            .:.|.|.         :||.:..|:....::.. |.|.:|.:..:..:|..::.|.|....:|
Human    73 CTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCS-ETSQELAEGQRRGSQGDSKQQNGKIPPKRPP 136

  Fly  1677 RRKVTEEFERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFV 1741
            |:.:.|.:.......|           .|.|..:.:.:             |||  ....:||..
Human   137 RKHIVERYTEFYHVPT-----------HSDASKKRLIE-------------DTE--DWRPRTGTT 175

  Fly  1742 ASQAKRLSCMEEEISSLTSQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPAESIVPGYATV 1806
            .|::.|:      ::.:|.......:.|.        |.:...|||  .|:..|.....|
Human   176 QSRSFRI------LAQITGTEHLKESEAD--------NTKKAKFDS--ALEDLPKSGPHP----- 219

  Fly  1807 PAATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQS-----SFAS-SSKATTSSLSSSSAS 1865
            ||..::||...    |.....:..:.:|...::|.:|:.|     :|:: ||.|..|:...|||:
Human   220 PATPQVLTIGS----QVATLSKVATTYSSLSSSTGNVEDSFEGFRNFSTFSSPARYSAAVLSSAA 280

  Fly  1866 ASASASVARSSQ--------SLTQASAITTTTNNQATT---AYRSSNGSI----------TKPNL 1909
            |:.||.:|..::        ||..|..|:..:...|.:   :.|.|.|||          ..|.|
Human   281 ATVSAVIATKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGSIHVKKTSNSQEPSPQL 345

  Fly  1910 ASRPSIASI-TAPGSASAP-APVPSAAPTKATAPFKAPI----VPKSVIANAVNAAAPPAPAVFP 1968
            ||  |:||. :.|.|..:| :..|......|.|.|| |:    |.||......|...|....:
Human   346 AS--SVASTRSMPESLDSPTSGRPGVTSLTAAAAFK-PVGSTGVIKSPSWQRPNQGVPSTGRI-- 405

  Fly  1969 PDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKA--AGPGVRIPLCNSCNVQIRGPF 2031
                     ||.....|:...:..|.|.|. |.....::.:|  ...|.|.|:|..||..|||||
Human   406 ---------SNSATYSGSVAPANSALGQTQ-PSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPF 460

  Fly  2032 ITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAI 2096
            :.|||:.|.|:.|.|  .:|:..:..||||||||.||||.|:||:.||.|.:|..||.|:.::|:
Human   461 LVALGKSWHPEEFNC--AHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISAL 523

  Fly  2097 GKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNY 2161
            .:.:|..||.|..|||...|..|.||||..|||.|:..||.|.|..|.||:||||.::|||.:.:
Human   524 KQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTW 588

  Fly  2162 HSQCFNCTFCKQNLEGQSFYNKGGRPFCKNHA 2193
            |..||.|:.|.::||||:|::|..:|.||.||
Human   589 HDTCFVCSVCCESLEGQTFFSKKDKPLCKKHA 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	28/52 (54%)
		LIM	2081..2132	CDD:259829	22/50 (44%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	25/52 (48%)
PDLIM5	NP_001243355.2	PDZ_signaling	10..82	CDD:238492	15/73 (21%)
		DUF4749	105..201	CDD:406377	22/136 (16%)
		LIM1_ENH	449..500	CDD:188837	28/52 (54%)
		LIM	508..559	CDD:413332	22/50 (44%)
		LIM3_ENH	567..621	CDD:188843	27/54 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149566
Domainoid	1	1.000	78	1.000	Domainoid score	I8783
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm41228
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.810