Protein Alignment Zasp52 and synpo2lb

DIOPT Version :10

• Sequence 1: NP_001027420.2
• Gene: Zasp52 / 36740
• FlyBaseID: FBgn0265991
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_001341280.3
• Gene: synpo2lb / 100001241
• ZFINID: ZDB-GENE-090828-5
• Length: 1184
• Species: Danio rerio
• Alignment Length: 1339
• Identity: 287/1339 - (21%)
• Similarity: 423/1339 - (31%)
• Gaps: 488/1339 - (36%)

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            |||||||||.:..:||.|.||...|.:.:|||:..|.::.||||...:|.|.:|.:::.......
Zfish    15 PWGFRLQGGAEHQKPLQVAKVRKRSKACRAGLRETDELLSINDVSCGSLSHAEAMNLIDSGRGTL 79

  Fly    83 VITVQRGGSTWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAAR----PFSNG 143
            .:.::|..:.:: .|...|..|.|                     .|...|..|.|    |.|:.
Zfish    80 HLRIKRAPAPYQ-SVVLVGRAPSP---------------------RIDKEYRAALRALSPPLSSK 122

  Fly   144 GDGGVKSIVNK-QYNTPVGIY-------SDESIAETLSAQAEVLAGGVLGVNFKKNEKEYQGDRS 200
            ..|     ||: ...:|.|:.       |:....|| .:.|:|.|          .|::.:..|
Zfish   123 PSG-----VNRASLMSPTGLEWLTSPPDSEAYYGET-DSDADVAA----------QERQRRQKR- 170

  Fly   201 EVLKFLREEET------GQSTP----AFGNSHYEHDAPQQLQQPQQQ------------------ 237
                  |...|      ||::|    ..|.|.||  :.|.:..||.|
Zfish   171 ------RSPSTSPAKIPGQTSPQEEETSGLSGYE--STQDVMYPQTQSWPVPDVEGMGTLQKQVM 227

  Fly   238 ---------YNQHQQHYHQQQQQQQSSTTRHVSA----------PVNSPKP-------------- 269
                     :...|..:.||.:....::.:..|.          |...|.|
Zfish   228 HGVARREVVFQPQQNEWSQQGENSSENSDQSPSGAAEVDSGFQEPPTVPPPLVSPERAKEALMLA 292

  Fly   270 ------PSTG---------------------GLPTGQNI-----------CTECERLIT------ 290
                  |..|                     .|..|:::           |.....|:|
Zfish   293 SHRQMVPMVGPVDNPVDEELTVTYMDKARQAKLHRGESLQDKQVKEARSKCRTIASLLTDAPNPH 357

  Fly   291 --GVFV----RIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLY------CDIHAKQAAINNPPT 343
              ||.:    |.:.|...:.||. :..|.|..|......:..|:      .|.....||.:  ||
Zfish   358 SKGVLMFKKRRQRAKKYTLTCFG-SVDGESNSNTEGETEDESLFPGSESELDEDGFSAAPD--PT 419

  Fly   344 GTEGYVPVPIKPNTKLSA-------STISSALN-SHGYGGH---------SNGYSNGNSTPAPAP 391
            ...||:.|..|   :.||       :.||..|| :.|.|..         ....||.|:...|..
Zfish   420 WDSGYLDVLDK---RTSACIVPDREAEISPGLNATSGKGAQLFEQQRKRAEEHVSNLNTFSMPQH 481

  Fly   392 VASSQATATVATVAPSAATAATAAATPQAATATDSPAATASSSDNMSAYVADEPSSIYGQISAES 456
            ...|  |.|...|||         .|||         :|:|.|.:|   |..||.    .:|..|
Zfish   482 QGDS--TLTYTPVAP---------YTPQ---------STSSLSTSM---VNGEPL----VVSRTS 519

  Fly   457 VALAPPPPQPPTAGGGDQPFEYVTLTGNVIRSVQAPGKGACPSYKVNQGYARPFGAA-----APK 516
            |.|:.|         |..|..  :|||.:...:.:....:     |:...||||...     |..
Zfish   520 VVLSSP---------GQTPMP--SLTGALPEQIDSSAASS-----VHNRTARPFAPGCVSNRAAT 568

  Fly   517 SPVSYPPQQQQQSPRPAPGGQN---PYATLPR--SNVGQQGGEAVEELQPEFEEEDCYEMDIEVA 576
            :||.:.|     ||....|.|:   ..||||.  |.|..:|.:|:....................
Zfish   569 APVVFRP-----SPAKKAGSQSQAVSVATLPAAFSPVVSEGKKAISTSSLYIPARPATYNGPSSL 628

  Fly   577 LAASRQSQRGSSFTWPPPQDDSHLAPTAAPLYIP---------PPETQHV-----------VVSN 621
            |:.|  |...|.|: |||.:        ||||.|         .|.|.||           ..|.
Zfish   629 LSPS--SVISSPFS-PPPSN--------APLYSPTYSSTSAPFSPTTSHVTSLSLPSGMAQTYSQ 682

  Fly   622 PVQQVPPLPP-GGATARLDPQPVVGTSAN-------GAPQWQSYSAPQLTTASARQLAEQESSSD 678
            | |.:|..|| ...:::..|.|.|...|.       .||.:.:......|:.:.:.....:.|.:
Zfish   683 P-QAMPFSPPHPTVSSQFQPPPPVNVPAQPFSSSFMNAPGFPNVPVHPPTSLNMQPSPSHKVSFN 746

  Fly   679 SYTSTSTTTTTTSEEYQRMYAAQVQAYQMQEQSGSEFDYQVDYASTQDSVQDYPSGRRSAQECVD 743
            .|.|.::||..|..      |...|.|.:...:        |..|:::.....|:||
Zfish   747 PYISVASTTPETPN------APIAQQYPLSNST--------DGISSREQRLSVPAGR-------- 789

  Fly   744 SLAVPLSTYKLVDMVREVTPSPV-TTPTQTPAPAAPTTRRVVFNDEPEIKELPQ---------LP 798
                   |..|.:..|..|..|: :...:..||:        ||  ||:..|.|         :.
Zfish   790 -------TGILQEACRRSTKKPMFSAQEEKKAPS--------FN--PELLSLVQNFDDRSRSGVE 837

  Fly   799 AELETIPEASEAVEDREGLVIEQRCQILESERKFQPTPEIKIEIAPVRQIPPTKIPNPMPKEWIN 863
            |..|:.||     ||...|..| .|..:::::...|.|     :||       |..:|.|
Zfish   838 AGFESGPE-----EDFLNLGAE-ACNFMQAQKNRLPPP-----VAP-------KPGHPAP----- 879

  Fly   864 PMIRVLTTAPEVPFHLVECPFPRPCGDDFEAEAAAAEAAKTQEVPEPLPPQVSAAPPATVSVEPS 928
                             |.|..|..|    ||..|...::.........|:..|.|.     :||
Zfish   880 -----------------EMPQMRGKG----AELFARRQSRMDRYVVDKQPKSPAQPR-----DPS 918

  Fly   929 PAPLRESPPRGSRLSQAMVTAPEFELKFAPPADQGIPLPEETEPYMPPPIDTKPYLREDYRPKSP 993
            |.|   |.|.              ..|::|            ....||||:..|.|    .|..|
Zfish   919 PTP---SLPG--------------NWKYSP------------NIRAPPPINYNPLL----SPSCP 950

  Fly   994 FVSALTTAPD-------RPFEGHFDKDVPIHMIDLPTPKEHLSMCDALCTAPERGYTPLNPE--- 1048
            .|:..:|..:       :...||              .|:.:...|.:...|.:    |||.
Zfish   951 LVAQRSTKANDATKVGVKTMHGH--------------NKQGIKALDFVSKQPYQ----LNPSLFS 997

  Fly  1049 ---NAMHRVDEEQKQQELKKREFQVLDHEEELGIRPE---PPQSV-----EYYETRR-DQPRKSS 1101
               |..:....:|:||             ..:||..:   ||:.|     ..||.:| ..|...|
Zfish   998 YGANPQNNTTCQQQQQ-------------NGVGITGQFLNPPKQVPIKAGRVYEIKRFSTPTPMS 1049

  Fly  1102 A-------FAAMQAFQPSREPLSSNTVSNAGSVADTPRA 1133
            |       ..|.::.....||:..:.|::...||..|.|
Zfish  1050 APTSLTPTVIAPRSATTLGEPMWRSDVTSPPPVAPRPAA 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_ZASP52-like	8..88	CDD:467281	26/69 (38%)
		DUF4749	150..>218	CDD:464948	17/85 (20%)
		LIM_ALP_like	282..333	CDD:188746	14/68 (21%)
		PHA03247	<762..1006	CDD:223021	54/260 (21%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
synpo2lb	XP_001341280.3	PDZ_SYNPO2-like	7..84	CDD:467264	26/68 (38%)
		PHA03247	<494..878	CDD:223021	113/498 (23%)