Protein Alignment ITGA2B and if

DIOPT Version :10

• Sequence 1: XP_011523051.2
• Gene: ITGA2B / 3674
• HGNCID: 6138
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Alignment Length: 939
• Identity: 283/939 - (30%)
• Similarity: 446/939 - (47%)
• Gaps: 133/939 - (14%)

Human    49 RRKMARALCPLQALWLLEWVLLLLGPCAAPPAWALNLD-PVQLTFYAGPNGSQFGFSLDFHKDSH 112
            ||:|| ..||:.:|     :|||:    |..|...|:| |..:.|....| |.||||:..||...
  Fly     8 RRRMA-LHCPITSL-----ILLLI----AMSAHGYNIDLPSYVRFRQSSN-SMFGFSIAMHKGRS 61

Human   113 G------RVAIVVGAPR--TLGPSQ--EETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQ 167
            |      .|:::||||:  |....|  .|.||||.|....:  .|..:.||.:...|||..:.:.
  Fly    62 GFYGNQNNVSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDD--DCKLVPFDSKGNNRNVDKEVVD 124

Human   168 TFKARQGLGASVVSW--SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRG 230
            . |:.|.|||:|.:.  ||::|||||...::.:..:......|||:||.:. ......|.||||.
  Fly   125 R-KSYQWLGATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSH-NFEEFYEVSPCRT 187

Human   231 NTLSRIYVENDFSWD---KRYCEAGFSSVVTQAG-ELVLGAPGGYYFLGLLAQAPVADIFSSYRP 291
            |           :|.   :..|:||||:.:...| .|.:||||.:|:.|.....|....|....|
  Fly   188 N-----------NWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPP 241

Human   292 GILLWHVSSQSLSFDSSNPE--YF----------DGYWGYSVAVGEFDGDLNTTEYVVGAPTWSW 344
            ....:.....:.|.|.:.||  .|          |.|.|||:..|:|||| .:.:..:|.|....
  Fly   242 LYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGD-RSEDVAIGMPRGGN 305

Human   345 TLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGR 409
            .:|.:.:.......:..:.|.|:..|||:|:|.:||:|||..|||:|||:|.:........:|||
  Fly   306 LVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGR 370

Human   410 VYLFLQPRGPHALGAPS--------LLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPS 466
            ||:.||       |.|:        .:..|....||||.|:..|||::.|||.|.||.|||.||.
  Fly   371 VYILLQ-------GGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPE 428

Human   467 GRGQVLVFLGQSEGLRSRPSQVLDS-------PFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGA 524
            |||.|.:|.|...|..::|||::.|       |:|  ..|||:|.|.:|:|.|.||||.||||.:
  Fly   429 GRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYP--RTFGFALSGGLDMDGNTYPDLAVGAYSS 491

Human   525 NQVAVYRAQPVVKASVQ--------LLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIP 581
            :||.:::::||...:.:        |:..|.     :||.|.:....|.|..:..|...||..:|
  Fly   492 DQVFIFKSRPVAAVNAETSFASNSKLISLDD-----RSCQLVRDHKKVPCMLLTTCWSYTGRYLP 551

Human   582 QKLSLNAELQLDRQKPRQGRRVLLL--GSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKL 644
            ::|..:....||.:|....|...|.  |......|:.|:.|.|:   |.....:|.|:.  :|||
  Fly   552 EQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKY---CLNETVYLLDKV--QDKL 611

Human   645 SPIVLSLNVSLPPT----------EAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTAS 699
            :|:.:....:|..:          .:.:.|.:..:.:..:::...|..:||.|::|.|.|:|..|
  Fly   612 TPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVS 676

Human   700 VTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFER---LICNQKKE 761
             |....|.|:...|.:::..:|..|.|:||...:..|....: |.|..: |.::   :.|:....
  Fly   677 -TVDKYLFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQF-RKLQQL-GEKKDTPITCSPPTP 738

Human   762 NETRVVLCELGNPMK--KNAQIGIAMLVSVGNLEEAGESVS--FQLQIRSKNSQNPNSKI---VL 819
            .....:.|::|||::  |.|...|:::..    |:.|.|.|  |..:..|.|.:.|.|:.   :.
  Fly   739 ENNHTLKCDIGNPLESGKIAHFKISLVPE----EKYGSSSSYDFYWEANSTNLEKPGSEYDNKIR 799

Human   820 LDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSL--DSWGPKVEHTYELHNNGPGTVNGLHLS 882
            ..|.:..:..::::|.|.|...:..|::.:..:|:.  |..||:|.|.||:.||.|..:....:.
  Fly   800 QSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVF 864

Human   883 IHLPGQSQPSD-LLYILDIQPQ--GGLQC 908
            ||||.::...| |:|:|: ||:  |.:||
  Fly   865 IHLPYETIVGDPLMYLLN-QPETGGKIQC 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGA2B	XP_011523051.2	Int_alpha	97..153	CDD:214549	23/65 (35%)
		Int_alpha	313..>353	CDD:214549	14/49 (29%)
		Int_alpha	367..418	CDD:214549	24/50 (48%)
		Int_alpha	435..489	CDD:214549	29/53 (55%)
		Int_alpha	496..>536	CDD:214549	19/39 (49%)
		Integrin_alpha2	533..972	CDD:462478	101/411 (25%)
		Integrin_alpha	1037..1051	CDD:459778
if	NP_523378.2	Int_alpha	46..110	CDD:214549	23/66 (35%)
		Int_alpha	275..>316	CDD:214549	13/41 (32%)
		Int_alpha	398..451	CDD:214549	29/52 (56%)
		Int_alpha	466..>497	CDD:214549	18/30 (60%)
		Integrin_alpha2	500..892	CDD:462478	99/409 (24%)
		Glutenin_hmw	<1121..1216	CDD:367362