DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cep89 and CEP89

DIOPT Version :9

Sequence 1:NP_611053.1 Gene:Cep89 / 36733 FlyBaseID:FBgn0266708 Length:476 Species:Drosophila melanogaster
Sequence 2:NP_116205.3 Gene:CEP89 / 84902 HGNCID:25907 Length:783 Species:Homo sapiens


Alignment Length:525 Identity:125/525 - (23%)
Similarity:209/525 - (39%) Gaps:129/525 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PDPNQQQHHQNPKKNRK-------VLQTLSGNFNRRSRSVEVEVKRQDNLGVVHKDRKKDRSFNS 71
            |...||:..::|..|.|       .....|.:...|:|....|:.|:....:    ::::...|:
Human   192 PQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEAL----KEENMDLNN 252

  Fly    72 LLQAKDQQLEQLVQRLATLHRYNDQFAKENDQLR-KDSGQLERRLTEAE----QQVANCSRCQQL 131
            :.|:...:|..:.|.:..|            ||: |...:.:|:|.|||    |:||        
Human   253 MNQSLTLELNTMKQAMKEL------------QLKLKGMEKEKRKLKEAEKASSQEVA-------- 297

  Fly   132 GQRLDTVLAQNRTLAGDVDMLKTLVFRLNVQIESYQDQ-RRLG-------EGAPTCGGSTKVSSS 188
            ...|..:..|.:.|..:.|.||..|.||||::..||.: |.|.       ||.|          |
Human   298 APELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLP----------S 352

  Fly   189 SAPYPP--LPTHTLGPLLQAYDESLRDKDALLAQYNTEFEHFTGELKRALEENTKLLQSQEQLRR 251
            ..|.||  |....|.|||.||::.:::||.|.|....|...|...::..::||       |:|.:
Human   353 KGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKEN-------EELHQ 410

  Fly   252 DLG--------GWREERVCLQAQLGVCRSK-----AEAQTRKT-DLAKEKLVEVMHCYEQRM--- 299
            :|.        .||:.:.  ||:|.:..:|     .|.|.||. |..:|:|.||....:|.|   
Human   411 ELNKSSAVTSEEWRQLQT--QAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLE 473

  Fly   300 -----QTLILDMDHLQAAYARTKSELAALKSASSAAPAAVAPPVPAESEALHQCKALLEQLRQEH 359
                 |...|..:..|....|.|.:  .||:.|....|     |......:::.|:   ||::|.
Human   474 AKTHGQEKELAENREQLEILRAKCQ--ELKTHSDGKIA-----VEVHKSIVNELKS---QLQKEE 528

  Fly   360 ARERTCLQEQLQATTARAASLVRSTEKAKHSRDRLKARLRMALQWAQKLEAGQAEVRDTYEAVRR 424
            .:||..::|.::..|...|. .:|....|:|.......|...|:.|||:..         ::.::
Human   529 EKERAEMEELMEKLTVLQAQ-KKSLLLEKNSLTEQNKALEAELERAQKINR---------KSQKK 583

  Fly   425 LEVLVQHKE-------------SQLRGLHARNAEEMDKL----RHKLQQKEETICALLR-----G 467
            :|||.:..|             :.|.||.....:|.|.|    :....:|:..:..:::     |
Human   584 IEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648

  Fly   468 KMERR 472
            |:|.:
Human   649 KLEEK 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cep89NP_611053.1 SH3_and_anchor <78..172 CDD:275056 28/99 (28%)
Smc <211..>459 CDD:224117 66/286 (23%)
CEP89NP_116205.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..49
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 63..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 175..226 7/33 (21%)
SH3_and_anchor <233..346 CDD:275056 33/136 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28PXP
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D224704at33208
OrthoFinder 1 1.000 - - FOG0008025
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR36170
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
44.010

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