DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep89 and cep89

DIOPT Version :9

Sequence 1:	NP_611053.1	Gene:	Cep89 / 36733	FlyBaseID:	FBgn0266708	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_005169029.1	Gene:	cep89 / 393852	ZFINID:	ZDB-GENE-040426-1210	Length:	866	Species:	Danio rerio

Alignment Length:	561	Identity:	125/561 - (22%)
Similarity:	209/561 - (37%)	Gaps:	163/561 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TDLDQPDPNQQQHHQNPK----KNRKVLQTLSGNFNRRSRSVEVEVKRQDNLGVVHKDRKKDRSF 69
            :.|.||....::...:|:    .:.:.|:|.....:|.::...|.|            .::|||
Zfish   230 SSLPQPRSVSRRSMASPELDDWSSPRSLKTSKRKSSRTNKESPVRV------------NERDRS- 281

  Fly    70 NSLLQAKDQQLEQLVQRLATLHRYNDQFAKENDQLRKDSGQLERRLTEAEQQVANCSRCQQL--- 131
                   .:..|.|...|...|....:..::|..|.::...||:|..:..|.:.:..  |:|
Zfish   282 -------SEDSEVLRSTLEVQHALVKELKEQNQILSQEKETLEKRCLQQSQHMKHLQ--QELCHT 337

  Fly   132 ----------GQRLDTVLAQNRTLAGDVDMLKTLVFRLNVQIESYQ--------DQRRLGEGAPT 178
                      |..|.::..|.:.|..:.|.||..|.||||::..||        |:....:|.|.
Zfish   338 HRERGNSTGEGSELSSLRQQAQELVDENDGLKMTVHRLNVELSRYQARFRPLTKDENAQLKGLPV 402

  Fly   179 CGGSTKVSSSSAPYPP--LPTHTLGPLLQAYDESLRDKDALLAQYNTEFEHFTGELKRALEENTK 241
            .|          |.||  |....|.|||.||::.|..||.||.....|.:......:..::||.|
Zfish   403 KG----------PAPPWLLDMKYLSPLLLAYEDHLNAKDKLLKSCEEELQSLRVRAEEVIQENEK 457

  Fly   242 L---------------LQSQEQLRRDLGGWREERVCLQAQLGVCRSKA-EAQTRKTDLAKE--KL 288
            |               .|.|||.|..|    ||...|..||.:..:|| ||.::.   |:|  |:
Zfish   458 LHTQVSKSSTVSNKEWRQLQEQARLVL----EENQVLIEQLELQHAKAKEAHSKH---AQEVCKV 515

  Fly   289 VEVMHCYEQRMQTLILDMDHLQAAYARTKSELAALKSASSAAPAAVAPPVPAESEALHQCKALLE 353
            .:.:...|...|:|..:::..:..:...|:|...::.|..            .|.:|.:.:.:.:
Zfish   516 SKKVMLLEAEKQSLEKELEVERKEHRALKTEFQRVRLALE------------HSLSLAEHQTVTD 568

  Fly   354 QLR---QEHARERTCLQEQLQATTA-----RAASLVRSTEKAKHSRDRLKARLRMALQWAQKLEA 410
            :|:   |:|.:.:||..|.||...:     |...|:..|....|.: .|:..|:::.|..:|
Zfish   569 KLKRQLQDHEKVKTCEVEDLQVRLSALEVERKTLLLDKTNLNTHIK-HLETELQLSQQANRK--- 629

  Fly   411 GQAEVRDTYEAVRRLEVLVQ---------------------------HKESQL-----------R 437
                      |.||:.||.|                           |:..||           :
Zfish   630 ----------AQRRISVLKQQVEDSLEKELIAHQYLANIVTLAEKTTHERDQLMLMASTLEKDKQ 684

  Fly   438 GLHARNAE---EMDKLRHKL----QQKEETICALLRGKMER 471
            |:..|..|   .:.||:.|:    :|...::|||.|...|:
Zfish   685 GVLTRIIESTVNLGKLQEKVKVYKKQASASVCALGRRLREQ 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep89	NP_611053.1	SH3_and_anchor	<78..172	CDD:275056	27/114 (24%)
Cep89	NP_611053.1	Smc	<211..>459	CDD:224117	68/318 (21%)
cep89	XP_005169029.1	HAUS4	474..635	CDD:291405	45/193 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9759
eggNOG	1	0.900	-	-		E1_28PXP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	68	1.000	Inparanoid score	I5338
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224704at33208
OrthoFinder	1	1.000	-	-		FOG0008025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR36170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.060