DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Impbeta11 and KAP120

DIOPT Version :9

Sequence 1:	NP_788357.1	Gene:	Impbeta11 / 36732	FlyBaseID:	FBgn0284254	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_015200.1	Gene:	KAP120 / 855978	SGDID:	S000006046	Length:	1032	Species:	Saccharomyces cerevisiae

Alignment Length:	1144	Identity:	259/1144 - (22%)
Similarity:	478/1144 - (41%)	Gaps:	242/1144 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ASVEQL-VAQTLQAATNPSH---EIVQKAEAQLREWEQQPGFFPTIARLSMRRGGGGDVVSSTED 78
            :|:.:| :.|.|:.|:||.|   ::.:.||.|||:||.|.||...:..:.:..           .
Yeast     3 SSLNELNLVQVLEQASNPQHIRSDVQKLAEQQLRQWETQAGFHYLLQSIYLNL-----------S 56

  Fly    79 SEVKVRWMAAVYLKNGVERYWRPNSRQELPAEQKQQIREVLLRHYDAEEVPQVALQVAVLLGRLA 143
            :.:::||:|.:..||||::|||......:|.::|..||..|....| |:..|:.:|.|....|:|
Yeast    57 NSLQIRWLAVIQFKNGVDKYWRSTRINAIPKDEKASIRGRLFEMID-EQNNQLCIQNAQASARIA 120

  Fly   144 RTDYPRFWPDLLPTLMKQLQSCGTD----GDSALQQRILIVLHYVLKALASRRLMAEQRAFQE-- 202
            |.|:|..|    |||.:.|::...|    .||.....||:.::.::|.|.:.|:...:.|.|.
Yeast   121 RLDFPVEW----PTLFEDLENLLNDEIIRKDSVKIYNILMHINQIVKVLGTARIGRCRPAMQSKV 181

  Fly   203 ---LGLQIFGYL-AWDIWAPLTTRFLQLVRKDEAMALNALQRAYVVMRTLRKLVVYGCAKPYKS- 262
               |.|.:..|| :::.|    |....|..:|    |::||.:|:.::.||:::..|..:|...
Yeast   182 PLILPLIVRIYLQSFEEW----TTSSNLNYED----LSSLQVSYLALKVLRRIICEGYDRPQTDQ 238

  Fly   263 -----------------TDHMNFVE-QLFQRLRQCL-ELRYELKVGSATPGTATILTELERFVIK 308
                             ::|.||.: .::::..:|| :|.:.|..||..           .|::
Yeast   239 SVCDFIKLSVSHFEMLISNHENFKKFDIYEKFIKCLGKLYFNLVTGSPA-----------NFIL- 291

  Fly   309 MMKTLNELMERHSVSFARFVPVALEFSFHYVFHEGTALIFDAGDRINFKN----------FAIQA 363
                               :|.:.:....|     |.||||...::..:|          .||:.
Yeast   292 -------------------LPCSTQILITY-----TRLIFDKAPKVYRENSDVTGDFWEQTAIRG 332

  Fly   364 LNMLKGIM----LSGNDSISAPPEGGAHIEDELL--ASAAQSQAKFFTAERVTYICEKIVTHYFL 422
            |.:||.::    ..|..::.|.       .|:|.  ||..:...:|.....:|.:.:.::..|..
Yeast   333 LLILKRVINFIHKKGAITLKAR-------SDKLTIDASINKINTEFLNENLITRLVDTLMEWYLR 390

  Fly   423 LTQQELEEWQQDPEGYDQDDGGGDAWKYALRPSVETLYFTCFTQHSQVMIPEVLRFVRR-AQQLQ 486
            |...|||.|..|||.:..:. ...:::|.:||..|.::.......|::::|.:|:.:.. |.:|
Yeast   391 LRPTELENWFMDPEEWINEQ-MATSYEYQIRPCAENVFQDLMNTFSELLVPYLLKKIENDASKL- 453

  Fly   487 LTPESDLKAILLKDAIYNAVGQAAFHFFNKLDFGAWLTSQLLAE---LRVEALNFRILRRRIIWL 548
               .:.|...|.|||||.:...:|......:||...|....|.|   ..:.....||:|||:..:
Yeast   454 ---SNSLDDFLRKDAIYASFQLSASAVSEMVDFDRLLIQVFLPEATNTNISGDELRIIRRRVALI 515

  Fly   549 VGHWVGVQLPRELRPLAYEACLHLLRPQEDMPTRLAAARTLNLLIDDFEFMPEAFHPYFPSLFEA 613
            :..|..|:...|.:.|.|:...:.|..::|....|...:|:..::||:.|..:.|.|:   |.|.
Yeast   516 INEWSTVKCSEESKSLCYKLFTNFLTDEDDKVVLLTTVQTVRTMVDDWNFNKDTFQPF---LTEN 577

  Fly   614 LFLLLHE----AGECDTKIVVLGTMTLLVEKMSEYIEPQAL-QFIAYLPLLWR---ESEEHDLLR 670
            :.|||.:    ....:|::.||.|::.::.:....|....| :.:..:|.||.   .:....:|.
Yeast   578 VHLLLRKILPSVSLTETRLYVLNTLSDIIIQTKPLISRDLLVEILQIIPNLWEIATNNASEAILA 642

  Fly   671 CAIIGTLEQLVRTIRDVPEPMKPFLYSVIELSTDLQQPSHVYLIEDGIMLWLAVIGNSTALTPEL 735
            .|::..|..||.::.............|:.|:.|.....:..|.|||..||..::.|.::...|.
Yeast   643 NALLRLLRNLVSSLGSQSHLTWDIAIPVVALACDPSSMQYQLLSEDGYELWGMLLQNFSSHDQEF 707

  Fly   736 LGLCDHLLPI----IEMSSENLRTVLQLIHAY-ILLDAQAYLSRYGEGFVAYCVRSFEDI----- 790
            ......|:|.    ||..:|.|.|:|::|.:| ::|:...:.|.          .:|:||
Yeast   708 DDKFVELVPFLKYGIETHTEILPTLLEIIKSYALILNPVDFFSN----------NTFQDIFKQMS 762

  Fly   791 ------RVEGIIAMLRIIETCLKTDAALGLRLV------RPALPFVFQQVCLKQEYPMTMGWYL- 842
                  |.:....:|.|.|..:.::.:....|:      ...|..:|..:.| :|.|.:   ||
Yeast   763 KYLLKLREDSFQLVLEIWEILILSNESDYENLLLQKFYETGVLSALFDAIFL-EEAPSS---YLC 823

  Fly   843 ----TIVARTLLIDQSVFMSVV----QQLPQADALAR---------------------ILDVWIE 878
                .|:||...::....|:.:    ..||.::..||                     :|..||.
Yeast   824 SQIIQIIARISYVNPDALMTFLATYHDNLPTSNENARMPESIRKIVSKDQTYDSVVNKLLTGWIV 888

  Fly   879 MFPMVPDTHAEKRKLFCLAFASIFGSNEL-LLARLPHILQLVDETLGEVMDKQYAATEEGASQAT 942
            .|..:.|  .:.:|:..|..:|:..:..: :|.....|..|..|.|.|:.:     |..|..
Yeast   889 CFRDIFD--PKFKKVHILGISSLLRTGLVPILTEFSSIASLWIEMLEEINE-----TNRGDC--- 943

  Fly   943 PRFYDSLVIHDEHELDDLQQQLGSGGGVSEE---FHTKGYPAKTYHDDRHRQLVL-KDPVYKIPL 1003
                      :::.|:|:         |:|:   ||     ..|....|:.||.. .|||:.|.|
Yeast   944 ----------EKYHLNDI---------VTEQSIAFH-----PLTAEQLRYHQLCKNNDPVHNISL 984

  Fly  1004 TEYLKWQLQSLQAQLGSQRYEQVMCSVVPEVRERITMYI 1042
            .:::...::.|::.||.:||::.:.::.|.:.|.:.|::
Yeast   985 KDFISQSMEYLESHLGVERYQEFLKTINPSLLENLQMFL 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Impbeta11	NP_788357.1	CSE1	23..>768	CDD:227944	195/811 (24%)
Impbeta11	NP_788357.1	IBN_N	42..120	CDD:197981	24/77 (31%)
KAP120	NP_015200.1	CSE1	8..1023	CDD:227944	258/1137 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343198
Domainoid	1	1.000	150	1.000	Domainoid score	I938
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I840
Isobase	1	0.950	-	0	Normalized mean entropy	S3455
OMA	1	1.010	-	-		QHG55426
OrthoFinder	1	1.000	-	-		FOG0005593
OrthoInspector	1	1.000	-	-		oto99362
orthoMCL	1	0.900	-	-		OOG6_102979
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R629
SonicParanoid	1	1.000	-	-		X4003
TreeFam	1	0.960	-	-
	15	14.740