DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Impbeta11 and Ipo11

DIOPT Version :9

Sequence 1:	NP_788357.1	Gene:	Impbeta11 / 36732	FlyBaseID:	FBgn0284254	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001347826.1	Gene:	Ipo11 / 76582	MGIID:	2442377	Length:	984	Species:	Mus musculus

Alignment Length:	1052	Identity:	367/1052 - (34%)
Similarity:	595/1052 - (56%)	Gaps:	101/1052 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SVEQLVAQTLQAATNPSHEIVQKAEAQLREWEQQPGFFPTIARLSMRRGGGGDVVSSTEDSEVKV 83
            |...:|.|.|..||:....:::.||.||::||.||||:..:..           :.:....::.|
Mouse     5 SASSVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLN-----------IFTNHTLDINV 58

  Fly    84 RWMAAVYLKNGVERYWRPNSRQELPAEQKQQIREVLLRHYDAEEVPQVALQVAVLLGRLARTDYP 148
            ||:|.:|.|:|::||||..:...|..|:|..:|..|:.::: |.:.|:|.|:|||:.::||.|.|
Mouse    59 RWLAVLYFKHGIDRYWRRVAPHALSEEEKSTLRAGLITNFN-EPINQIATQIAVLIAKVARLDCP 122

  Fly   149 RFWPDLLPTLMKQLQSCGTDGDSALQQRILIVLHYVLKALASRRLMAEQRAFQELGLQIFGYLAW 213
            |.||:|:|||::.::.    .|...|.|.|:..::|.|.|||:||.|:::.|.:|...|:.: |.
Mouse   123 RQWPELIPTLVESVKV----QDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNF-AC 182

  Fly   214 DIWAPLTTRFLQLVRK-DEAMALNALQRAYVVMRTLRKLVVYGCAKPYKSTDHMNFVEQLFQRLR 277
            .:|...|..|||.|.. :||..|::|:|..:.::.||||.|.|..:|:|:.:.|.|:..:|:||:
Mouse   183 SLWNHHTDTFLQHVSSGNEAAVLSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLK 247

  Fly   278 QCLELRYELKVGSATPGTATILTE-LERFVIKMMKTLNELMERHSVSFARFVPVALEFSFHYVFH 341
            |.||.       |.:.||..:..: ||:.:|...|.|.:.:::|.:||...:..:||||..|||.
Mouse   248 QFLEC-------SRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPISFTPLIQRSLEFSVSYVFT 305

  Fly   342 EGTALIFDAGDRINFKNFAIQALNMLKGIML------SGNDSISAPPEGGAHIEDELLASAAQSQ 400
            |       .|:.:.|:.|.:|.:|::|.|:.      |.|...|:|....||          :.:
Mouse   306 E-------VGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAH----------KIK 353

  Fly   401 AKFFTAERVTYICEKIVTHYFLLTQQELEEWQQDPEGYDQDDGGGDAWKYALRPSVETLYFTCFT 465
            ..|||...:|.||.::|:||||||::||..|::||||:..::.|||:|||:|||..|.|:...|.
Mouse   354 MAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFH 418

  Fly   466 QHSQVMIPEVLRFVRRAQQLQ-LTPESDLKAILLKDAIYNAVGQAAFHFFNKLDFGAWLTSQLLA 529
            :::|.:.|.:|..:   |.|: .|...|:.|:|:|||:|||||.|||..|:.:||..|..:|||.
Mouse   419 EYNQTLTPVLLEMM---QTLEGPTNVEDMNALLIKDAVYNAVGLAAFELFDSVDFDQWFKTQLLP 480

  Fly   530 ELRVEALNFRILRRRIIWLVGHWVGVQLPRELRPLAYEACLHLLRPQEDMPTRLAAARTLNLLID 594
            ||:|....::.||||:|||:|.|:.|:...:|||:.|||..:||:.| |:..|:..|.||.|.:|
Mouse   481 ELQVSHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQ-DLVVRIETATTLKLTVD 544

  Fly   595 DFEFMPEAFHPYFPSLFEALFLLLHEAGECDTKIVVLGTMTLLVEKMSEYIEPQALQFIAYLPLL 659
            ||||..:.|.||..::|..||.||.:..|||||:.||..::.::|:::..|.|.....:.|||||
Mouse   545 DFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNVQIRPYVGCLVQYLPLL 609

  Fly   660 WRESEEHDLLRCAIIGTLEQLVRTIRDVPEPMKPFLYSVIELSTDLQQPSHVYLIEDGIMLWLAV 724
            |::||||::|||||:.||..||:.:....:.:.|||..||:||||:.||.||||:|||:.|||..
Mouse   610 WKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVT 674

  Fly   725 IGNSTALTPELLGLCDHLLPII---------EMSSENLRTVLQLIHAYILLDAQAYLSRYGEGFV 780
            :.||..:|||||.:..::.|::         |:|||||||..::|:.||.|.:..:|..|..|..
Mouse   675 LENSPCVTPELLRIFQNMSPLLELPSSCLANELSSENLRTCFKIINGYIFLSSTEFLQTYAAGLC 739

  Fly   781 AYCVRSFEDIRVEGIIAMLRIIETCLKTDAALGLRLVRPALPFVFQQVCLKQEYPMTMGWYLTIV 845
            ........:|..||.:.:|:::|..||.:..||.::.:..||.||:.|...:.||:.|..||.::
Mouse   740 QSFYELLPEITTEGQVQVLKVVENALKVNPVLGPQMFQRILPCVFRGVIEGERYPVVMSIYLAVM 804

  Fly   846 ARTLLIDQSVFMSVV--------QQLPQADALARILDVWIEMFPMVPDTHAEKRKLFCLAFASIF 902
            .|.||.:.|.|.|::        |::.|  .|..::::|::....:  |..|::||..||..|:.
Mouse   805 GRVLLQNTSFFSSLLNEMGHEFNQEMDQ--LLGNVIEMWVDRMDNI--TQPERKKLSALALLSLL 865

  Fly   903 GS-NELLLARLPHILQLVDETLGEVMDKQYAATEEGASQATPRFYDSLVIHDEHELDDLQQQLGS 966
            .| |.::..:...|:.:..|.|.:||      ||:..:    |.|...::..:||
Mouse   866 PSDNSVIQDKFCGIINISVEALHDVM------TEDPET----RTYKDCMLMSQHE---------- 910

  Fly   967 GGGVSEEFHTKGYPAKTYHDDRHRQLVLKDPVYKIPLTEYLKWQLQSLQAQLGSQRYEQVMCSVV 1031
                 |...|:.....|..|.|.:.|.|||||:.:.|.:::..:|::.|..||.|.::.:|.:|.
Mouse   911 -----EPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEILGEQGFQSLMETVD 970

  Fly  1032 PEVRERITMYIE 1043
            .|:..::..:::
Mouse   971 TEIVTQLQEFLQ 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Impbeta11	NP_788357.1	CSE1	23..>768	CDD:227944	294/762 (39%)
Impbeta11	NP_788357.1	IBN_N	42..120	CDD:197981	25/77 (32%)
Ipo11	NP_001347826.1	Cse1	10..981	CDD:332697	366/1044 (35%)
		HEAT 1	123..160		14/40 (35%)
		HEAT 2	283..317		13/40 (33%)
		HEAT 3	318..356		10/47 (21%)
		HEAT 4	422..459		16/39 (41%)
		HEAT repeat	426..459	CDD:293787	15/35 (43%)
		HEAT 5	473..509		17/35 (49%)
		HEAT repeat	478..505	CDD:293787	14/26 (54%)
		HEAT 6	511..548		18/37 (49%)
		HEAT repeat	515..545	CDD:293787	12/30 (40%)
		HEAT repeat	552..586	CDD:293787	15/33 (45%)
		HEAT 7	555..593		15/37 (41%)
		HEAT repeat	599..630	CDD:293787	17/30 (57%)
		HEAT 8	600..636		19/35 (54%)
		HEAT 9	640..677		21/36 (58%)
		HEAT 11	740..782		10/41 (24%)
		HEAT 12	828..858		8/33 (24%)
		HEAT 13	859..896		12/42 (29%)
		HEAT 14	966..983		3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	576	1.000	Domainoid score	I219
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7089
Inparanoid	1	1.050	637	1.000	Inparanoid score	I830
Isobase	1	0.950	-	0	Normalized mean entropy	S3455
OMA	1	1.010	-	-		QHG55426
OrthoDB	1	1.010	-	-		D198261at33208
OrthoFinder	1	1.000	-	-		FOG0005593
OrthoInspector	1	1.000	-	-		oto92927
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R629
SonicParanoid	1	1.000	-	-		X4003
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.920