DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Impbeta11 and IPO11

DIOPT Version :9

Sequence 1:	NP_788357.1	Gene:	Impbeta11 / 36732	FlyBaseID:	FBgn0284254	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001128251.1	Gene:	IPO11 / 51194	HGNCID:	20628	Length:	1015	Species:	Homo sapiens

Alignment Length:	1041	Identity:	365/1041 - (35%)
Similarity:	595/1041 - (57%)	Gaps:	88/1041 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SVEQLVAQTLQAATNPSHEIVQKAEAQLREWEQQPGFFPTIARLSMRRGGGGDVVSSTEDSEVKV 83
            |...:|.|.|..||:....:::.||.||::||.||||:..:..           :.:....::.|
Human    45 SASTVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLN-----------IFTNHTLDINV 98

  Fly    84 RWMAAVYLKNGVERYWRPNSRQELPAEQKQQIREVLLRHYDAEEVPQVALQVAVLLGRLARTDYP 148
            ||:|.:|.|:|::||||..:...|..|:|..:|..|:.::: |.:.|:|.|:|||:.::||.|.|
Human    99 RWLAVLYFKHGIDRYWRRVAPHALSEEEKTTLRAGLITNFN-EPINQIATQIAVLIAKVARLDCP 162

  Fly   149 RFWPDLLPTLMKQLQSCGTDGDSALQQRILIVLHYVLKALASRRLMAEQRAFQELGLQIFGYLAW 213
            |.||:|:|||::.::.    .|...|.|.|:..::|.|.|||:||.|:::.|.:|...|:.: |.
Human   163 RQWPELIPTLIESVKV----QDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNF-AC 222

  Fly   214 DIWAPLTTRFLQLVRK-DEAMALNALQRAYVVMRTLRKLVVYGCAKPYKSTDHMNFVEQLFQRLR 277
            .:|...|..|||.|.. :||..|::|:|..:.::.||||.|.|..:|:|:.:.|.|:..:|:||:
Human   223 SLWNHHTDTFLQEVSSGNEAAILSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLK 287

  Fly   278 QCLELRYELKVGSATPGTATILTE-LERFVIKMMKTLNELMERHSVSFARFVPVALEFSFHYVFH 341
            |.||.       |.:.||..:..: ||:.:|...|.|.:.:::|..||...:..:||||..|||.
Human   288 QFLEC-------SRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPFSFTPLIQRSLEFSVSYVFT 345

  Fly   342 EGTALIFDAGDRINFKNFAIQALNMLKGIML------SGNDSISAPPEGGAHIEDELLASAAQSQ 400
            |       .|:.:.|:.|.:|.:|::|.|:.      |.|...|:|....||          :.:
Human   346 E-------VGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAH----------KIK 393

  Fly   401 AKFFTAERVTYICEKIVTHYFLLTQQELEEWQQDPEGYDQDDGGGDAWKYALRPSVETLYFTCFT 465
            ..|||...:|.||.::|:||||||::||..|::||||:..::.|||:|||:|||..|.|:...|.
Human   394 MAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFH 458

  Fly   466 QHSQVMIPEVLRFVRRAQQLQ-LTPESDLKAILLKDAIYNAVGQAAFHFFNKLDFGAWLTSQLLA 529
            :::|.:.|.:|..:   |.|| .|...|:.|:|:|||:|||||.||:..|:.:||..|..:|||.
Human   459 EYNQTLTPVLLEMM---QTLQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLP 520

  Fly   530 ELRVEALNFRILRRRIIWLVGHWVGVQLPRELRPLAYEACLHLLRPQEDMPTRLAAARTLNLLID 594
            ||:|....::.||||:|||:|.|:.|:...:|||:.|||..:||:.| |:..|:..|.||.|.:|
Human   521 ELQVIHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQ-DLVVRIETATTLKLTVD 584

  Fly   595 DFEFMPEAFHPYFPSLFEALFLLLHEAGECDTKIVVLGTMTLLVEKMSEYIEPQALQFIAYLPLL 659
            ||||..:.|.||..::|..||.||.:..|||||:.||..::.::|:::..|.|.....:.|||||
Human   585 DFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLL 649

  Fly   660 WRESEEHDLLRCAIIGTLEQLVRTIRDVPEPMKPFLYSVIELSTDLQQPSHVYLIEDGIMLWLAV 724
            |::||||::|||||:.||..||:.:....:.:.|||..||:||||:.||.||||:|||:.|||..
Human   650 WKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVT 714

  Fly   725 IGNSTALTPELLGLCDHLLPIIEMSSENLRTVLQLIHAYILLDAQAYLSRYGEGFVAYCVRSFED 789
            :.||..:|||||.:..::.|::|:|||||||..::|:.||.|.:..:|..|..|.........::
Human   715 LENSPCITPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKE 779

  Fly   790 IRVEGIIAMLRIIETCLKTDAALGLRLVRPALPFVFQQVCLKQEYPMTMGWYLTIVARTLLIDQS 854
            |..||.:.:|:::|..||.:..||.::.:|.||:||:.:...:.||:.|..||.::.|.||.:.|
Human   780 ITTEGQVQVLKVVENALKVNPILGPQMFQPILPYVFKGIIEGERYPVVMSTYLGVMGRVLLQNTS 844

  Fly   855 VFMSVVQQLPQA------DALARILDVWIEMFPMVPDTHAEKRKLFCLAFASIFGS-NELLLARL 912
            .|.|::.::...      ..|..::::|::....:  |..|:|||..||..|:..| |.::..:.
Human   845 FFSSLLNEMAHKFNQEMDQLLGNMIEMWVDRMDNI--TQPERRKLSALALLSLLPSDNSVIQDKF 907

  Fly   913 PHILQLVDETLGEVMDKQYAATEEGASQATPRFYDSLVIHDEHELDDLQQQLGSGGGVSEEFHTK 977
            ..|:.:..|.|.:||      ||:   ..|..:.|.:::  .|              :.|...|:
Human   908 CGIINISVEGLHDVM------TED---PETGTYKDCMLM--SH--------------LEEPKVTE 947

  Fly   978 GYPAKTYHDDRHRQLVLKDPVYKIPLTEYLKWQLQSLQAQLGSQRYEQVMCSVVPEVRERITMYI 1042
            .....|..|.|.:.|.|||||:.:.|.:::..:|::.|..||.|.::.:|.:|..|:..::..::
Human   948 DEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEMLGEQGFQSLMETVDTEIVTQLQEFL 1012

  Fly  1043 E 1043
            :
Human  1013 Q 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Impbeta11	NP_788357.1	CSE1	23..>768	CDD:227944	294/753 (39%)
Impbeta11	NP_788357.1	IBN_N	42..120	CDD:197981	25/77 (32%)
IPO11	NP_001128251.1	CSE1	50..1012	CDD:227944	364/1033 (35%)
		IBN_N	68..140	CDD:281761	26/83 (31%)
		HEAT repeat	466..499	CDD:293787	16/35 (46%)
		HEAT repeat	518..545	CDD:293787	14/26 (54%)
		HEAT repeat	555..585	CDD:293787	12/30 (40%)
		HEAT repeat	592..626	CDD:293787	15/33 (45%)
		HEAT repeat	639..670	CDD:293787	17/30 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	573	1.000	Domainoid score	I221
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7089
Inparanoid	1	1.050	634	1.000	Inparanoid score	I837
Isobase	1	0.950	-	0	Normalized mean entropy	S3455
OMA	1	1.010	-	-		QHG55426
OrthoDB	1	1.010	-	-		D198261at33208
OrthoFinder	1	1.000	-	-		FOG0005593
OrthoInspector	1	1.000	-	-		oto89354
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4003
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.890