DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Impbeta11 and Cse1

DIOPT Version :9

Sequence 1:	NP_788357.1	Gene:	Impbeta11 / 36732	FlyBaseID:	FBgn0284254	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	1140	Identity:	214/1140 - (18%)
Similarity:	395/1140 - (34%)	Gaps:	296/1140 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QLVAQTLQAATNPSHEIVQKAEAQLREWEQQPGFFPTIARLSMRRGGGGDVVSSTEDSEVKVRWM 86
            ||:|..||...:....:.:.||..|...|.|..:  .|..|::         ......::..|..
  Fly     9 QLLAGYLQQTLSADPNVRRPAEKLLESTELQQNY--PILLLNL---------IDKAQMDMTTRVA 62

  Fly    87 AAVYLKNGVERYWRPNSRQELPAEQKQQIRE-----------VLLRHYDAEEVPQVALQVAVLLG 140
            .|:..||.::|.|..:    |.::...:|.|           .|:.|.......|::..|::
  Fly    63 GAIAFKNYIKRNWAAH----LDSDGPDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSI--- 120

  Fly   141 RLARTDYPRFWPDLLPTLMKQLQSCGTDGDSALQQRILIVLHYVLKALASRRLMAEQRAFQELGL 205
             :.:.|:|:.||.|:..::::..|    ||..:...:|...|.:.|..  |.....|..::|:..
  Fly   121 -IGKYDFPKKWPQLIDEMVERFAS----GDFNVINGVLQTAHSLFKRY--RYEFKSQALWEEIKF 178

  Fly   206 QIFGYLAWDIWAPLT-----TRFLQLVRKDEAMALNALQRAYVVMRTLRKLVVYGCAK---PYKS 262
             :...:|    .|||     |..|..|.::.|.||..:..:.|::..    |.:....   |...
  Fly   179 -VLDRMA----KPLTDLLQATMQLTKVHENNAGALKVIYGSLVLVNK----VFFSLNSQDLPEFF 234

  Fly   263 TDHMN-----FVEQLFQRLRQCLELRYELKVGSATPGTATILTE----LERFVIKMMKTLNELME 318
            .|::|     |::||                .:..|...|...|    ||....::.:.:....:
  Fly   235 EDNINTWMGAFIQQL----------------AADVPSLRTADDEDAGVLEHLRAQVCENICLYAK 283

  Fly   319 RHSVSF----ARFVPVALEFSFHYVFHEGTALIFDAGDRINFKNFAIQALNMLKGIMLSGNDSIS 379
            ::...|    .:||....|            |:........:.:....||..|
  Fly   284 KYDEEFKPFMEQFVTAVWE------------LLVKTSLHTKYDSLVSHALQFL------------ 324

  Fly   380 APPEGGAHIEDELLASAAQSQAKFFTAERVTYICEKIVTHYFLLTQQELEEWQQDPEGYDQDDGG 444
                       .::|.....|:.|...|.:..||:|:|.....:...:.|.::..||.|.:.|..
  Fly   325 -----------SVVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIE 378

  Fly   445 G---DAWKYALRPSVETL-------YFTCFTQHSQVMIPEVLRFVRRAQQLQLTPESDLKAILLK 499
            |   |..:.|....|:||       .|..|.|:.:          |...:.:..|.::.::   |
  Fly   379 GSDIDTRRRAACDLVKTLSINFEQKIFGIFGQYLE----------RLLTKYKENPATNWRS---K 430

  Fly   500 D-AIYNAVGQAAFHFFNKLDFGAWLTS-----------QLLAELRVEALN-FRILRRRIIWLVGH 551
            | |||.....|:.....|  .|...||           |::.||....:| |.:|:...|..|..
  Fly   431 DTAIYLVTSWASRGGTQK--HGITQTSELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMV 493

  Fly   552 WVGVQLPRELRPLAYEACL-HLLR--PQEDMPTRLAAARTLNLLI------DDFEFMPEAFHPYF 607
            :..:     |.|....:|| .|:|  |.|.......||.::..::      :...|.|:...||.
  Fly   494 FRSI-----LGPQVLASCLPQLIRHLPAESSVVHSYAACSVEKILSMRDASNAIVFGPQILAPYT 553

  Fly   608 PSLFEALFLLLHEAGECDTKIVV--------------LGTMTLLVEKMSEYI-----EPQALQFI 653
            ..|...||..|...|..:.:.|:              :..|.:.:.:::|.:     .|...||.
  Fly   554 TELISGLFATLSLPGSGENEYVMKAIMRSFSVLQSAAMPFMGVALPRLTEILTQVAKNPSRPQFN 618

  Fly   654 AYLPLLWRESEEHDLLRC---------AIIGTLEQLVRTI------RDVPEPMKPFLYSVIELST 703
            .||        ...|..|         :.:.:.|:.:..:      :|:.|.| |:::.::.:..
  Fly   619 HYL--------FETLALCIKIVCHADSSAVSSFEEALFPVFQGILQQDIVEFM-PYVFQMLSVLL 674

  Fly   704 DLQQPSHVYLIEDGIMLWLAVIGNST------ALTPELLGLCDHLLPIIEMSSENLRTVLQLIHA 762
            ::::                  |..|      ||.|.||.      |.:...:.|:..:::||.|
  Fly   675 EMRE------------------GTGTIPEPYWALFPCLLS------PALWDRTGNVTPLIRLISA 715

  Fly   763 YILLDAQAYLSRYGE-----GFVAYCVRSFEDIRVEGIIAMLRIIETCLKTDAALGLRLVRPALP 822
            :| ....|.:...|:     |.....:.|..:.. ||...:..::......:....||.:   ..
  Fly   716 FI-KQGSAQIQALGKLSGILGIFQKMIASKANDH-EGFYLLQNLLSYYPPAEIQTNLRQI---FG 775

  Fly   823 FVFQQVCLKQEYPMTMGWYLTIVARTLLIDQSVFMSVVQQLPQADALARILD-VWIEMFPMVPDT 886
            .:||::.|.:......|..:......:....|....::.:: |.:....:|| |:|.....:|
  Fly   776 LLFQRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEI-QPNLFGMLLDRVFITEMGKIP-- 837

  Fly   887 HAEKRKLFCLAFASIFGSNELLLARLPHILQLVDETLGEVMDKQYAATEEGASQATPRFYDSLVI 951
            ..:.||:..:....       ||...|.|||           :|||.       ..||...||:.
  Fly   838 KEQDRKMVAVGVTK-------LLTETPEILQ-----------QQYAT-------FWPRLLHSLID 877

  Fly   952 HDEHELDDLQ-QQLGSGGGVSEEFHTKGYP---AKTYHDDRHRQ---LVLKDPVYKIPLTEYLKW 1009
            ..|...:.|. .::|...||:|: ...||.   |:..|...::|   ..:||      ..::|..
  Fly   878 LFERPPEKLMGLEIGETAGVAED-PDAGYQVAFAQLTHAQPNQQDHLAEIKD------ARQFLAT 935

  Fly  1010 QLQSLQAQLGSQRYEQVMCSVVPEVRERITMYIEQ 1044
            .|... ||..:..:..::..:.||.::.:..|.:|
  Fly   936 SLSKF-AQARAGEFSTLLSPLEPEYKQVLQKYCDQ 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Impbeta11	NP_788357.1	CSE1	23..>768	CDD:227944	158/848 (19%)
Impbeta11	NP_788357.1	IBN_N	42..120	CDD:197981	16/88 (18%)
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	17/90 (19%)
		Cse1	159..528	CDD:285678	87/450 (19%)
		CAS_CSE1	530..966	CDD:281384	90/509 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5657
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10997
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930