Protein Alignment Gmppa and EIF2B3

DIOPT Version :10

• Sequence 1: NP_611051.2
• Gene: Gmppa / 36730
• FlyBaseID: FBgn0034035
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_065098.1
• Gene: EIF2B3 / 8891
• HGNCID: 3259
• Length: 452
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 93/539 - (17%)
• Similarity: 170/539 - (31%)
• Gaps: 211/539 - (39%)

  Fly     5 VILIGGPQKGTRFRPLSLDTPKPLFPLAGRPLIAHHIEACAQLPDIREILIIGYYPQTQME--GF 67
            |:.:||   |:|...|:...||||.|:..:|||                    :||...:|  ||
Human     7 VMAVGG---GSRMTDLTSSIPKPLLPVGNKPLI--------------------WYPLNLLERVGF 48

  Fly    68 -------VGDMQ-ALYSSSNINIR----YLQEFTALGTAGGMYHFRDQIRAGNPRAFFVLNGDVC 120
                   ..|:| ||.:...:.::    .:.:...:|||..:.:...:::..    ..||:.|:.
Human    49 EEVIVVTTRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTD----VLVLSCDLI 109

  Fly   121 ADFPLQELCDFHEKRPASALVTI-------------------------------------MSTEA 148
            .|..|.|:.|......||..:.:                                     |:.||
Human   110 TDVALHEVVDLFRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEA 174

  Fly   149 TRQQSL----------------------HYGCLV-----FDRSSGAVS--------HYVEKPSSY 178
            ...:.|                      |..||.     |...:|:::        :.|.|..|.
Human   175 DLDEELVIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSS 239

  Fly   179 VSTFINCG----------VYVCSMDIFTVLAQIFHSRGQEY-SCQAFCNGNGNGNGREQGHIKWE 232
            .|:  ..|          ..:.|:||::.:.:........| :|...|.|:           :||
Human   240 ASS--QQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGD-----------RWE 291

  Fly   233 --------------QEVLTPLAGTDKLFAMPVPNWWSQLKTAGSAIYANRHYLGLYKKTHPERLA 283
                          :|.|.                 |::.|.|..:.|||..        |:.|
Human   292 DLSRSQVRCYVHIMKEGLC-----------------SRVSTLGLYMEANRQV--------PKLL- 330

  Fly   284 NVGIKRGEGDGSLICTVHPDVYVHPSATVHHSAVLGPNVAIGPGVTIGPGVRIRESIVLEQAQIL 348
                       |.:|...|.  ||.||.:....::|.:..|||...||....|:.|::.....|.
Human   331 -----------SALCPEEPP--VHSSAQIVSKHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIK 382

  Fly   349 DHTLVLHSIVGRGSTIGAWARVEGTPSDPDPNKPFAKMENPPLFNNEGKLNPSITILGCFV---- 409
            |...:.:.::....|:...:.::|:                 :..|...:.....|..|.:
Human   383 DRVTITNCLLMNSVTVEEGSNIQGS-----------------VICNNAVIEKGADIKDCLIGSGQ 430

  Fly   410 QVPAEKILLNSIVLPHKEL 428
            ::.|:...:|.:::.:.:|
Human   431 RIEAKAKRVNEVIVGNDQL 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gmppa	NP_611051.2	M1P_guanylylT_A_like_N	4..270	CDD:133050	66/375 (18%)
		LbetaH	306..372	CDD:469633	15/65 (23%)
EIF2B3	NP_065098.1	eIF-2B_gamma_N	3..212	CDD:133041	42/231 (18%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	15/96 (16%)