DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8207 and Eif2b5

DIOPT Version :9

Sequence 1:	NP_611051.2	Gene:	CG8207 / 36730	FlyBaseID:	FBgn0034035	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_620221.2	Gene:	Eif2b5 / 192234	RGDID:	708380	Length:	716	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	76/438 - (17%)
Similarity:	159/438 - (36%)	Gaps:	141/438 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKAVILIGGPQKGTRFRPLSLDTPKPLFPLAGRPLIAHHIEACAQLPDIREILIIGYYPQTQMEG 66
            |:||::.....:  ||.|:|.|.|:.|.|||...||.:.:|... ...::|..:...:...|::.
  Rat    38 LQAVLVADSFDR--RFFPISKDQPRVLLPLANVALIDYTLEFLT-ATGVQETFVFCCWKAAQIKE 99

  Fly    67 FVGDMQALYSSSNINIRYLQE--FTALGTAGGMYHFRDQIRAGNPRA-----FFVLNGDVCADFP 124
            .:...:..:.:|...:|.:..  :.:||         |.:|..:.:|     |.::.|||.::..
  Rat   100 HLQKSKWCHPTSLNVVRIITSDLYRSLG---------DVLRDVDAKALVRSDFLLIYGDVVSNIN 155

  Fly   125 LQELCDFHE-KRPASALVTIM----------------------STEATRQQSLHYGCLVFDRSSG 166
            :.:..:.|. :|.....|::|                      :.::|..:.||     |.::.|
  Rat   156 ISKALEEHRLRRKLEKNVSVMTMVFKESSPSHPTRCHEDNVVLAVDSTTNRILH-----FQKTQG 215

  Fly   167 AVSHYVEKPSSYVSTF-------------INCGVYVCSMDIFTVLAQIFHSRGQEYSCQAFCNGN 218
             :.|:    |..:..|             ::|.:.:||..:    ||:|.......:...|..|
  Rat   216 -LRHF----SFPLGLFQGSLDGVEIRYDLLDCHISICSPQV----AQLFTDNFDYQTRDDFVRG- 270

  Fly   219 GNGNGREQGHIKWEQEVLTPLAGTDKLFAMPVPNWWSQLKTAGSAIYANRHYLGLYKKTHPERLA 283
                      :...:|:|                             .|:.:|.:..:.:..|::
  Rat   271 ----------LLVNEEIL-----------------------------GNQIHLHVTSREYGARVS 296

  Fly   284 NVGIKRGEGDGSLICT------VHP--------------------DVYVHPSATVHHSAVLGPNV 322
            |:.:.      |.:|.      |:|                    ::|..|..::.|.:||..||
  Rat   297 NLHMY------SAVCADVIRRWVYPLTPEVNFTDSSTQSYTHSRHNIYRGPEVSLGHGSVLEENV 355

  Fly   323 AIGPGVTIGPGVRIRESIVLEQAQILDHTLVLHSIVGRGSTIGAWARV 370
            .:|.|..:|....|..|::.....|.|:.::..:.:.:|..:.|.|::
  Rat   356 LLGAGTVVGSNCSITNSVIGPNCHIGDNVVLDQAYLWQGVRVAAGAQI 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8207	NP_611051.2	GCD1	1..366	CDD:224129	74/432 (17%)
		M1P_guanylylT_A_like_N	4..270	CDD:133050	51/308 (17%)
		LbetaH	306..372	CDD:294107	16/65 (25%)
Eif2b5	NP_620221.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		GCD1	37..433	CDD:224129	76/438 (17%)
		eIF-2B_epsilon_N	38..252	CDD:133040	44/239 (18%)
		LbH_eIF2B_epsilon	356..434	CDD:100061	10/48 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..481
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..539
		W2_eIF2B_epsilon	543..713	CDD:211396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810