Protein Alignment Cdk5 and CDC28

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_009718.3
• Gene: CDC28 / 852457
• SGDID: S000000364
• Length: 298
• Species: Saccharomyces cerevisiae
• Alignment Length: 300
• Identity: 163/300 - (54%)
• Similarity: 211/300 - (70%)
• Gaps: 17/300 - (5%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKG---RNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKN 62
            :..|.::||:||||||.|:|.   |......:||||::||:.:||||||:|:|||.||||||..|
Yeast     5 LANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDN 69

  Fly    63 IVRLIDVLHSD-KKLTLVFEHCDQDLKKYFDSL--NGEIDMAVCRSFMLQLLRGLAFCHSHNVLH 124
            ||||.|::||| .||.||||..|.|||:|.:.:  :..:...:.:.||:||.:|:|:||||.:||
Yeast    70 IVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILH 134

  Fly   125 RDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAG 189
            ||||||||||||:|.|||.|||||||||:|::.|:.|:||||||.|:||.|.|.|:|.:|.||.|
Yeast   135 RDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIG 199

  Fly   190 CILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSW-----S 249
            ||.||:.:. :|:|.|...:||:.|||||||||||..||.:.:|.|:  .||||   .|     |
Yeast   200 CIFAEMCNR-KPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDF--KPSFP---QWRRKDLS 258

  Fly   250 QLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDS 289
            |:||.|:.:|.|||.|||...|..||||..|..||||.:|
Yeast   259 QVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	160/293 (55%)
CDC28	NP_009718.3	STKc_CDK1_CdkB_like	8..295	CDD:270829	160/292 (55%)