DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk5 and pef1

DIOPT Version :9

Sequence 1:	NP_477080.1	Gene:	Cdk5 / 36727	FlyBaseID:	FBgn0013762	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_587921.1	Gene:	pef1 / 2539366	PomBaseID:	SPCC16C4.11	Length:	288	Species:	Schizosaccharomyces pombe

Alignment Length:	287	Identity:	162/287 - (56%)
Similarity:	214/287 - (74%)	Gaps:	8/287 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLID 68
            |.::||:|||||..|:||:||.|.||||||.:|:|. |||.||:|:|||.|:|||:|.||:.|.|
pombe     3 YQRLEKLGEGTYAHVYKGQNRVTGEIVALKVIRIDA-DEGTPSTAIREISLMKELRHPNIMSLSD 66

  Fly    69 VLHSDKKLTLVFEHCDQDLKKYFDSL--NGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQN 131
            ||.::.||.||||:.::|||||.|:.  .|.:..:..::|..|||:|::|||.:.||||||||||
pombe    67 VLQTENKLMLVFEYMEKDLKKYMDTYGNQGALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQN 131

  Fly   132 LLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELA 196
            ||||..||||||||||||:.||||..:|.||||||||.||||.|:::|:||||:||.|||:||:|
pombe   132 LLINSRGELKLADFGLARSIGIPVNTFSNEVVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMA 196

  Fly   197 DAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITS--WSQLVPRLNSKG 259
             .|||||.||:..|||:||||:||||.|.||||:|.|.:|  .|:||...:  .:.|.|..:..|
pombe   197 -TGRPLFAGSNNEDQLLKIFRLLGTPTEQSWPGISLLPEY--KPTFPIYKAQDLAYLFPTFDPLG 258

  Fly   260 RDLLQKLLICRPNQRISAEAAMQHPYF 286
            .|||:::|..:|..|.:.:.|:||.:|
pombe   259 LDLLRRMLRLQPELRTTGQDALQHAWF 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	PLN00009	1..288	CDD:177649	162/287 (56%)
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	161/285 (56%)
pef1	NP_587921.1	PKc_like	2..285	CDD:304357	161/285 (56%)
pef1	NP_587921.1	PLN00009	3..285	CDD:177649	161/285 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3623
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X3829
TreeFam	0	0.000	Not matched by this tool.
	7	6.940