Protein Alignment Cdk5 and Cdk18

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_032821.1
• Gene: Cdk18 / 18557
• MGIID: 97518
• Length: 451
• Species: Mus musculus
• Alignment Length: 296
• Identity: 167/296 - (56%)
• Similarity: 214/296 - (72%)
• Gaps: 5/296 - (1%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            ::.|.|::|:|||||.||||||::.|..:||||.:|| |.:||.|.:|:||:.|||:|||.|||.
Mouse   118 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRL-EHEEGAPCTAIREVSLLKDLKHANIVT 181

  Fly    66 LIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQ 130
            |.|::|:|:.||||||:.|.|||:|.|.....::|...:.||.|||||||:||...:||||||||
Mouse   182 LHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQ 246

  Fly   131 NLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAEL 195
            |||||:.|||||||||||||..:|.|.||.|||||||||||||.|:..|:|.||||..||||.|:
Mouse   247 NLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEM 311

  Fly   196 ADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQL--VPRLNSK 258
            | .|:||||||.|.::|..|||:||||.|:|||||:.:|::.|. :||.......|  .|||:::
Mouse   312 A-TGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAY-NFPRYLPQPLLSHAPRLDTE 374

  Fly   259 GRDLLQKLLICRPNQRISAEAAMQHPYFTDSSSSGH 294
            |.:||..||:.....|:|||||:.||||.......|
Mouse   375 GINLLSSLLLYESKSRMSAEAALNHPYFQSLGDRVH 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	164/284 (58%)
Cdk18	NP_032821.1	Protein Kinases, catalytic domain	115..402	CDD:473864	164/286 (57%)