Protein Alignment Cdk5 and Cdkl5

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: XP_017457779.1
• Gene: Cdkl5 / 100362725
• RGDID: 2324133
• Length: 1001
• Species: Rattus norvegicus
• Alignment Length: 297
• Identity: 115/297 - (38%)
• Similarity: 172/297 - (57%)
• Gaps: 20/297 - (6%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            |.|::.:..:|||.||.|.|.|:::|.||||:|:.:..|::|.|..:.|||:.:|:.||.:|||.
  Rat    10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVE 74

  Fly    66 LIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQ 130
            |.:......||.||||:.::::.:..:.:...:.....:|::.||::.:.:||.::::|||:||:
  Rat    75 LKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPE 139

  Fly   131 NLLINKNGELKLADFGLARAFGIPVKC-YSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAE 194
            ||||:.|..|||.|||.||........ |:..|.|.|||.|::|.||. |..|:||||.||||.|
  Rat   140 NLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP-YGKSVDMWSVGCILGE 203

  Fly   195 LADAGRPLFPGSDVLDQLMKIFRVLG-TPNEDSWPGVSHLSDYVALP-----SFPAITSWSQLVP 253
            |:| |:|||||...:|||..|.:||| .|:|       .:..:.:.|     .|||:.....|..
  Rat   204 LSD-GQPLFPGESEIDQLFTIQKVLGPLPSE-------QMKLFYSNPRFHGLRFPAVNHPQSLER 260

  Fly   254 R----LNSKGRDLLQKLLICRPNQRISAEAAMQHPYF 286
            |    |||...||::.||...|..|...|..:.||.|
  Rat   261 RYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	113/293 (39%)
Cdkl5	XP_017457779.1	STKc_CDKL5	11..297	CDD:270838	113/294 (38%)