DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8195 and YML018C

DIOPT Version :9

Sequence 1:	NP_611049.1	Gene:	CG8195 / 36725	FlyBaseID:	FBgn0034032	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_013694.1	Gene:	YML018C / 854990	SGDID:	S000004480	Length:	393	Species:	Saccharomyces cerevisiae

Alignment Length:	425	Identity:	117/425 - (27%)
Similarity:	191/425 - (44%)	Gaps:	84/425 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QRLLLGISILVLVDVVWVSSSELTKFLYNEANFDKPFFCTYFKTSMFSIYLL--VIGILAPWKES 68
            :|..||:.:|.||.::||.||.|...::.:.::.||||.||..|:.|..||.  ...::..:|::
Yeast    11 KRWTLGLLMLGLVIILWVLSSFLINLIFEDDSYRKPFFITYTNTAAFIFYLFPTAKAVVVNYKDT 75

  Fly    69 CERQNGNYAMMEQNADDENYYSNQAVLGDPTYVPIRSPHLGAGGQSNGTSNSISGTESDDSSVRS 133
            .........:||:.                          |.|..||                ||
Yeast    76 GRANVHRELIMEEE--------------------------GTGSDSN----------------RS 98

  Fly   134 VRFSKMAEVREMSAHEATDALMARLSYAASLRIRRQKTHHKTAKTALLFCLLWFAANYFFQLALE 198
            |              :.|..|:..|........:::.|.::|.|.:..||:|||.||.....:|.
Yeast    99 V--------------DMTSPLLTNLEAGTHANQKKRLTLYETIKLSAEFCILWFTANLVTNASLA 149

  Fly   199 MDEAAMITLVSSTSSFFIICLAAVFPSATGDKLTITKVIAVAMNIGGVVAITMNDLHD------- 256
            ....|..|::|:|||||.:.:.|:   ...:.|:.:||:...::..|::.:|.:|.|.
Yeast   150 FTSVASQTILSTTSSFFTLFIGAI---CHVESLSKSKVLGSFISFVGIIMVTKSDSHQRYQRHIA 211

  Fly   257 ---------TKMTRGVLLALFSAFFYAAYLVFVKRKSDTEEKVDIPLFFGFVGLWNMLLLWPIFF 312
                     .::..|.||||..|..|..|...:||:...|.:|::.:|||||||:|:|.|||...
Yeast   212 DVSGDDNDAVQVLIGNLLALAGAVLYGVYSTLLKREVGDETRVNMKIFFGFVGLFNLLFLWPSLI 276

  Fly   313 ILHFTKIETFELPSQGQ-FALLFLNGLVGTVLSEALWLWGCFLTSSLIGTLAMSLQIPLAILFDV 376
            :|.|...|.|.||...: ..::|:|.|: |.:|:..|.....|||.|..|:.:|:.||||:..||
Yeast   277 VLDFFGWEPFSLPKDPKVVVIIFVNCLI-TFVSDFCWAKAMLLTSPLTVTVGLSITIPLAMFGDV 340

  Fly   377 LLKNKPYSPMFYMGSIPIFVALVFVSLLMRNDDSD 411
            :.|:|..|.::..|:     .|:..|..:.|..|:
Yeast   341 IFKHKTMSALYLFGA-----TLILGSFFIINKSSE 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8195	NP_611049.1	2A78	153..399	CDD:273359	81/262 (31%)
CG8195	NP_611049.1	EamA	260..403	CDD:279264	53/143 (37%)
YML018C	NP_013694.1	RhaT	<142..367	CDD:223769	71/233 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0697
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5745
Inparanoid	1	1.050	156	1.000	Inparanoid score	I1079
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55723
OrthoFinder	1	1.000	-	-		FOG0004517
OrthoInspector	1	1.000	-	-		otm46776
orthoMCL	1	0.900	-	-		OOG6_103193
Panther	1	1.100	-	-	LDO	PTHR23051
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1847
SonicParanoid	1	1.000	-	-		X4898
TreeFam	1	0.960	-	-
	14	13.790