DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8195 and SLC35F5

DIOPT Version :9

Sequence 1:	NP_611049.1	Gene:	CG8195 / 36725	FlyBaseID:	FBgn0034032	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001317244.1	Gene:	SLC35F5 / 80255	HGNCID:	23617	Length:	536	Species:	Homo sapiens

Alignment Length:	479	Identity:	202/479 - (42%)
Similarity:	295/479 - (61%)	Gaps:	50/479 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GRTQ--RLLLGISILVLVDVVWVSSSELTKFLYNEANFDKPFFCTYFKTSMFSIYLLVIGILAPW 65
            |.||  |:.|||.||:||||:||:|||||.:::.:  ::||||.|:.|||||.:|||...|..||
Human    62 GFTQRRRMALGIVILLLVDVIWVASSELTSYVFTQ--YNKPFFSTFAKTSMFVLYLLGFIIWKPW 124

  Fly    66 KESCER-QNGNYAMMEQNADDENYY-------SNQAVLGDPTYVPIRSPHLGAGGQSNGTSNSIS 122
            ::.|.| ..|.:|..  .||.|.|:       :..:.|.:|.|||::...|    .|....::..
Human   125 RQQCTRGLRGKHAAF--FADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDL----PSEKPESTNI 183

  Fly   123 GTESDDSSVRSVRFSKMAEVREMSAHEATDALMARLSYAASLRIRRQKTHHKT---------AKT 178
            .||......| ||||.:.|:|::.:..|.:|.::|:||.    ::.|::..||         ||.
Human   184 DTEKTPKKSR-VRFSNIMEIRQLPSSHALEAKLSRMSYP----VKEQESILKTVGKLTATQVAKI 243

  Fly   179 ALLFCLLWFAANYFFQLALEMDEAAMITLVSSTSSFFIICLAAVFPSATGDKLTITKVIAVAMN- 242
            :..||.:||.||..:|.||...:.|::.::||||..|.:.|||||||.:||:.|::|::||.:.
Human   244 SFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILRL 308

  Fly   243 ------------IGGVVAITM--NDLHDTKMTRGVLLALFSAFFYAAYLVFVKRKSDTEEKVDIP 293
                        |||||.:.:  ::....:.|.|.:.:|..|..||.|:|.:|||.|.|:|:|||
Human   309 DKEGNGYKILNFIGGVVLVNLAGSEKPAGRDTVGSIWSLAGAMLYAVYIVMIKRKVDREDKLDIP 373

  Fly   294 LFFGFVGLWNMLLLWPIFFILHFTKIETFELPSQGQFALLFLNGLVGTVLSEALWLWGCFLTSSL 358
            :|||||||:|:|||||.||:||:|..|.||.|::.....:.:|||:||||||.||||||||||||
Human   374 MFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIIINGLIGTVLSEFLWLWGCFLTSSL 438

  Fly   359 IGTLAMSLQIPLAILFDVLLKNKPYSPMFYMGSIPIFVALVFVSLLMRNDDSDPLMKLFRIVYRK 423
            |||||:||.|||:|:.|:.::...:|.:|:.|:||:|.:...|:||...::.||:|...|.::..
Human   439 IGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIVTLLCHYNNWDPVMVGIRRIFAF 503

  Fly   424 VCRCHKPSIVRV-NDDEQQESLIS 446
            :||.|:  |.|| .|.||.|||||
Human   504 ICRKHR--IQRVPEDSEQCESLIS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8195	NP_611049.1	2A78	153..399	CDD:273359	120/269 (45%)
CG8195	NP_611049.1	EamA	260..403	CDD:279264	79/142 (56%)
SLC35F5	NP_001317244.1	RhaT	<245..483	CDD:223769	112/237 (47%)
SLC35F5	NP_001317244.1	EamA	342..483	CDD:279264	78/140 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146567
Domainoid	1	1.000	171	1.000	Domainoid score	I3764
eggNOG	1	0.900	-	-		E1_COG0697
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5745
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2265
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55723
OrthoDB	1	1.010	-	-		D1084257at2759
OrthoFinder	1	1.000	-	-		FOG0004517
OrthoInspector	1	1.000	-	-		oto89792
orthoMCL	1	0.900	-	-		OOG6_103193
Panther	1	1.100	-	-	LDO	PTHR23051
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1847
SonicParanoid	1	1.000	-	-		X4898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800