DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bgamma and EIF2B3

DIOPT Version :9

Sequence 1:	NP_611046.2	Gene:	eIF2Bgamma / 36722	FlyBaseID:	FBgn0034029	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_016858234.1	Gene:	EIF2B3 / 8891	HGNCID:	3259	Length:	457	Species:	Homo sapiens

Alignment Length:	427	Identity:	150/427 - (35%)
Similarity:	245/427 - (57%)	Gaps:	55/427 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EFQAVVFAAGRGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFTEVIVVVLEQEKLEIQSA 67
            ||||||.|.|.|:|:.::....||.|||||..||||||||||::..|.|||||...    ::|.|
Human     2 EFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTR----DVQKA 62

  Fly    68 L-ENTPLKLRLDYATIPSDGDFGTADSLRYIYDKIKSDFLVVSCDLVSNVSLYPLINKFREHDAA 131
            | ....:|::.|...||.|.|.||||||||||.|:|:|.||:||||:::|:|:.:::.||.:||:
Human    63 LCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDLFRAYDAS 127

  Fly   132 LAMLLFPSGFESDVVMPGPKSKHK--PERDLIGIHAATQRLAFVSAASDCEETLNIQRHLLKNRG 194
            ||||: ..|.:|...:||.|.|.|  .:||.||:.:..:||.|::..:|.:|.|.|:..:|:...
Human   128 LAMLM-RKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHP 191

  Fly   195 RLDVYSRLVDAHVYVLKKWVIDYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTSEVGVVT 259
            |:..::.|||||:|.|||:::|:|....:|::.:.|.:|:|::||.|        ..:|:.|...
Human   192 RIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFS--------SASSQQGQEE 248

  Fly   260 KNEDHVLHYVGHTILDQKITQTSLFN-----QSLSQSPY-------HGD--------IVRCYGIQ 304
            |.||         :..:::....:::     .:|:.:||       .||        .|||| :.
Human   249 KEED---------LKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRCY-VH 303

  Fly   305 APRDAIGVRVNNTLSFLAINRKLASIWNNLCGEKHPLISPGAVVKSTQTKEIIAADN-----AKL 364
            ..::.:..||:....::..||::..:.:.||.|:.|:.|...:|    :|.::..|:     .::
Human   304 IMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIV----SKHLVGVDSLIGPETQI 364

  Fly   365 SEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEG 401
            .||:|:..||.|.:|:|..:..:.|.|:|::..||||
Human   365 GEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEG 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	99/213 (46%)
		GCD1	5..441	CDD:224129	148/425 (35%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	16/50 (32%)
EIF2B3	XP_016858234.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146910
Domainoid	1	1.000	140	1.000	Domainoid score	I4771
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7005
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3046
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54649
OrthoDB	1	1.010	-	-		D1388750at2759
OrthoFinder	1	1.000	-	-		FOG0004788
OrthoInspector	1	1.000	-	-		oto90372
orthoMCL	1	0.900	-	-		OOG6_102755
Panther	1	1.100	-	-	LDO	PTHR45989
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R375
SonicParanoid	1	1.000	-	-		X4472
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800