Protein Alignment eIF2Bgamma and GCD6

DIOPT Version :10

• Sequence 1: NP_611046.2
• Gene: eIF2Bgamma / 36722
• FlyBaseID: FBgn0034029
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_010497.3
• Gene: GCD6 / 851797
• SGDID: S000002619
• Length: 712
• Species: Saccharomyces cerevisiae
• Alignment Length: 492
• Identity: 106/492 - (21%)
• Similarity: 182/492 - (36%)
• Gaps: 121/492 - (24%)

  Fly     5 QAVVFAAGRGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFTEVIVVVLEQEKLEIQSALE 69
            ||||......||...:....|:||||:...|||.|.|..|.:....||.::...... :|...:|
Yeast    28 QAVVLTDSYETRFMPLTAVKPRCLLPLANVPLIEYTLEFLAKAGVHEVFLICSSHAN-QINDYIE 91

  Fly    70 N-------TPLKLRLDYATIPSDGDFGTADSLRYIYDK--IKSDFLVVSCDLVSNVSLYPLIN-- 123
            |       :|.|:    .||.|.....|.|.:|.:.::  |..||::||.|:::|:....::.
Yeast    92 NSKWNLPWSPFKI----TTIMSPEARCTGDVMRDLDNRGIITGDFILVSGDVLTNIDFSKMLEFH 152

  Fly   124 -----KFREHDAALAM----------LLFPSGFESDVV---------MPGPKSKHKPERDLIGIH 164
                 :.::|.:.:.:          .:.|:.|..|..         :|.|.|:.|
Yeast   153 KKMHLQDKDHISTMCLSKASTYPKTRTIEPAAFVLDKSTSRCIYYQDLPLPSSREK--------- 208

  Fly   165 AATQRLAFVSAASDCEETLNIQRHLLKNRGRLDVYSRLVDAHVYVLKKWVIDYLRRKENI----- 224
                    .|...|.|...|:...:::| ..:|....:..:||.::.:...||...:.:.
Yeast   209 --------TSIQIDPELLDNVDEFVIRN-DLIDCRIDICTSHVPLIFQENFDYQSLRTDFVKGVI 264

  Fly   225 -STFKGEFLPHLIKKQHSKRPPK-TVQDTTSEVGVVTKNEDHVLHYVGHTILDQKITQTSLFNQS 287
             |...|:.:...:..:::.|... ...||.|        :|.:..:....:||..|..    :|:
Yeast   265 SSDILGKHIYAYLTDEYAVRVESWQTYDTIS--------QDFLGRWCYPLVLDSNIQD----DQT 317

  Fly   288 LSQSPYHGDIVRCYGIQAPRDAIGVRVNNTLSFLAINRKLASIWNNLCGEKHPLISPGAVV-KST 351
            .|....|        |...:|.:          ||.:.|:.         |...|..|..: :.|
Yeast   318 YSYESRH--------IYKEKDVV----------LAQSCKIG---------KCTAIGSGTKIGEGT 355

  Fly   352 QTKEIIAADNAKLSEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNI---DNCIIGHRA 413
            :.:..:...|.::.|...:..|....:|||...:|:.:|||.|||.:  |.|:   |.||||.
Yeast   356 KIENSVIGRNCQIGENIRIKNSFIWDDCIIGNNSIIDHSLIASNATL--GSNVRLNDGCIIGF-- 416

  Fly   414 QVKSGSVLKNCIIGPNYVVEEGTHSQAVHLSNADQFM 450
                     |..|..|..::..|...|..|.||...|
Yeast   417 ---------NVKIDDNMDLDRNTKISASPLKNAGSRM 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	53/244 (22%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	23/82 (28%)
GCD6	NP_010497.3	eIF-2B_epsilon_N	27..243	CDD:133040	52/237 (22%)
		glgC	<256..408	CDD:179486	37/192 (19%)
		LbH_eIF2B_epsilon	344..422	CDD:100061	25/90 (28%)
		W2_eIF2B_epsilon	550..704	CDD:211396