Protein Alignment eIF2Bgamma and Gmppa

DIOPT Version :10

• Sequence 1: NP_611046.2
• Gene: eIF2Bgamma / 36722
• FlyBaseID: FBgn0034029
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001344100.1
• Gene: Gmppa / 69080
• MGIID: 1916330
• Length: 425
• Species: Mus musculus
• Alignment Length: 515
• Identity: 91/515 - (17%)
• Similarity: 169/515 - (32%)
• Gaps: 171/515 - (33%)

  Fly     5 QAVVFAAG--RGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQ-HNFTEVIVVVLEQEKLEIQS 66
            :||:...|  :|||...:..:.||.|.||...|:|.:.:....| ....|::::...|....:..
Mouse     3 KAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEALTQ 67

  Fly    67 ALE------NTPLKLRLDYATIPSDGDFGTADSLRYIYDKIKSD----FLVVSCDLVSNVSLYPL 121
            .||      |.|::...::|.:      ||...|.:..|:|.:.    |.|::.|:.|:..|..:
Mouse    68 FLEAAQQEFNLPVRYLQEFAPL------GTGGGLYHFRDQILAGAPEAFFVLNADVCSDFPLSAM 126

  Fly   122 INKFRE-----------------------------HDAALAMLLFPSGFESDVVMPG-----PKS 152
            :...|.                             |: .|..:..||.|.||::..|     |::
Mouse   127 LEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHE-VLHYVEKPSTFISDIINCGIYLFSPEA 190

  Fly   153 KHKPERDLIGIHAATQRLAFVSAASDCEE---------TLNIQRHLLKNRGRLDVYSRLVDAHVY 208
            . ||.||:...:....:|.....    ||         |:.:::         ||:|.|..
Mouse   191 L-KPLRDVFQRNQQDGQLCLALG----EESPGSWPGAGTIRLEQ---------DVFSALAG---- 237

  Fly   209 VLKKWVIDYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTSEVGVVTKNEDHVLH----YV 269
                               :|:...||                |..:....|:....|:    |:
Mouse   238 -------------------QGQIYVHL----------------TDGIWSQIKSAGSALYASRLYL 267

  Fly   270 GHTILDQKITQTSLFNQSLSQSP-YHGDI-VRCYGIQAPRDAIGVRVNNTLSFLAINRKLASIWN 332
            |.    .:||......:.....| ..|:: :......||...:|..|:
Mouse   268 GR----YQITHPERLARHTPGGPRIRGNVYIHPTAKVAPSAVLGPNVS----------------- 311

  Fly   333 NLCGEKHPLISPGAVV-KSTQTKEIIAADNAKLSEKTSLNFSVFG--------------PNCIIS 382
                     |..|..: :..:.:|.|....|.|.|.|.:..|:.|              ||   .
Mouse   312 ---------IGKGVTIGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPN---D 364

  Fly   383 PKNIVANSLIMSNAIVEEGCNIDN-CIIGHRAQVKSGSVLKNCIIGPNYVVEEGTHSQAV 441
            |......:.:.|.::.::|..:.. .|:|.|.::.:..::.|.|:.|:..:.....:|.:
Mouse   365 PNPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQII 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	53/265 (20%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	18/94 (19%)
Gmppa	NP_001344100.1	M1P_guanylylT_A_like_N	4..266	CDD:133050	59/321 (18%)
		Hexapeptide repeat domain. /evidence=ECO:0000250|UniProtKB:Q96IJ6	278..425		28/176 (16%)
		LbetaH	294..360	CDD:469633	14/91 (15%)
		C-loop. /evidence=ECO:0000250|UniProtKB:Q96IJ6	361..389		5/30 (17%)