DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bgamma and eif2b3

DIOPT Version :9

Sequence 1:	NP_611046.2	Gene:	eIF2Bgamma / 36722	FlyBaseID:	FBgn0034029	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001016997.2	Gene:	eif2b3 / 549751	XenbaseID:	XB-GENE-961434	Length:	458	Species:	Xenopus tropicalis

Alignment Length:	475	Identity:	155/475 - (32%)
Similarity:	264/475 - (55%)	Gaps:	45/475 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EFQAVVFAAGRGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFTEVIVVVLEQEKLEIQSA 67
            |.||||.|.|.|:|:.|:....||.|||||..||:|||||:|::..|.|.|||..::.:.|:|.:
Frog     4 ELQAVVMAVGGGSRMGELTASIPKPLLPVGNRPLLWYPLNMLERAGFEEAIVVTTKEVQREVQKS 68

  Fly    68 LENTPLKLRLDYATIPSD--GDFGTADSLRYIYDKIKSDFLVVSCDLVSNVSLYPLINKFREHDA 130
            ..:|  |::||...:|.|  .:.|||||||:||.|||:|.||.||||::.|:|:.:::.||.|:|
Frog    69 FPDT--KMKLDIVCLPEDKATEMGTADSLRHIYQKIKTDVLVTSCDLITEVALHEIVDLFRAHNA 131

  Fly   131 ALAMLLFPSGFESDVVMPGPKSKHK--PERDLIGIHAATQRLAFVSAASDCEETLNIQRHLLKNR 193
            :::||:..:. |....:||.|.|.|  .|||.||:......|..::...|.::.||:::.||:..
Frog   132 SVSMLMRKAS-EPIENVPGLKGKQKAVEERDFIGVDDKGTHLLLLANEEDLDDGLNLKKSLLQRY 195

  Fly   194 GRLDVYSRLVDAHVYVLKKWVIDYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTSEVGVV 258
            .|:.:...:||||:|.|:|:::|:|....:.|:.:.|.:|:|::||.       :...||:   .
Frog   196 PRIHIKMGMVDAHLYCLRKYIVDFLAGDHSFSSIRRELIPYLVRKQF-------LSSLTSQ---Q 250

  Fly   259 TKNEDHVLHYVGHTI---LDQKITQTSLFNQSLSQS-----------PYHGDIVRCYGIQAPRDA 309
            .|.|...|:....::   :...|||..|.:::|..|           ||||..:||| :....:.
Frog   251 KKEEQEELNGGKESMPNDIYSFITQDKLLDRALEMSCWNDHRGDMREPYHGSRLRCY-VHVAGNE 314

  Fly   310 IGVRVNNTLSFLAINRKLASIWNNLC--GEKHPLISPGAVVKSTQTKEIIAADN-----AKLSEK 367
            :..|||:...::..||::..:   ||  ..:.|.:.|.|::..   |.::.||:     .:::||
Frog   315 LCCRVNSLAMYIDANRQVPRL---LCEVSNEDPRVHPLAMIAD---KLMVGADSMIGAQTQVAEK 373

  Fly   368 TSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHRAQVKSGSVLKNCIIGPNYVV 432
            :|:..|:.|.||.|..:..:.|.:||:...::|.|.|...:|.:.|.::||:.:|:|::||..::
Frog   374 SSIKHSLLGSNCTIKDRVKITNCIIMNEVTIQECCTIQGSVICNNAVIESGADIKDCLVGPGLLI 438

  Fly   433 EEGTHSQAVHLSNADQFMEI 452
            ..........:...:|.|||
Frog   439 TSKAKRVNEIIMGNEQLMEI 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	89/214 (42%)
		GCD1	5..441	CDD:224129	150/460 (33%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	24/84 (29%)
eif2b3	NP_001016997.2	GCD1	4..439	CDD:224129	151/454 (33%)
eif2b3	NP_001016997.2	eIF-2B_gamma_N	5..217	CDD:133041	89/214 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5312
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7005
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3119
OMA	1	1.010	-	-		QHG54649
OrthoDB	1	1.010	-	-		D1388750at2759
OrthoFinder	1	1.000	-	-		FOG0004788
OrthoInspector	1	1.000	-	-		oto104179
Panther	1	1.100	-	-	LDO	PTHR45989
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4472
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080