DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bgamma and AT5G19485

DIOPT Version :9

Sequence 1:	NP_611046.2	Gene:	eIF2Bgamma / 36722	FlyBaseID:	FBgn0034029	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001031908.1	Gene:	AT5G19485 / 3770677	AraportID:	AT5G19485	Length:	456	Species:	Arabidopsis thaliana

Alignment Length:	460	Identity:	122/460 - (26%)
Similarity:	230/460 - (50%)	Gaps:	41/460 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EFQAVVFAAGRGTRL-PEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFTEVIVVVL-EQEKLEIQ 65
            :||.|:.|.|..:.| |.|..:.||.||||...|::.|.|:||:..|..::||||. |...|::.
plant     2 DFQVVILAGGFSSYLVPLVAKEVPKALLPVANRPVLSYVLDLLESSNLKDLIVVVEGEDAALKVG 66

  Fly    66 SALENTPL-KLRLDYATIPSDGDFGTADSLRYIYDKIKS-DFLVVSCDLVSNVSLYPLINKFREH 128
            ..:.:..: :|.::.|.:..  :.|||.:||.|...:.: |.|:||.|:||::....:....|.|
plant    67 GWISSACVDRLHVEVAAVAE--NVGTAGALRAIAHHLTAKDILIVSGDIVSDIPPGAVAATHRRH 129

  Fly   129 DAALAMLLF--PSGFESDVVMPGPKSKHKPER--DLIGIHAATQRLAFVSAASDCEETLNIQRHL 189
            |||:.::|.  |....|:....|.|.|.|...  |:||:.:..|.|.:::..::.::...:::.:
plant   130 DAAVTVMLCAQPVSGPSESGGSGGKDKTKKPACDDIIGLDSLKQFLLYIAKGTEIKKDTRVKKSI 194

  Fly   190 LKNRGRLDVYSRLVDAHVYVLKKWVI-DYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTS 253
            |...|::::.|.|:|:|:|..|:.|: :.|.:|....:.|.:.||:|::.|       ...|..|
plant   195 LCAAGKMEIRSDLMDSHIYAFKRAVLQEVLDQKPAFRSLKQDVLPYLVRTQ-------LRSDVFS 252

  Fly   254 EVGVVTKN-----EDHVLHYVGHTILDQKITQTSL------FNQSLSQSPYHGDIVRCYGIQAPR 307
            :...|.:|     ::::.:  ...:|.|.::..|:      :...|.....|    :|....|..
plant   253 DQSNVEENGNGNGKNNMQN--NEVVLSQILSNASMPSFHQVYESGLGTRKTH----KCCVYIADE 311

  Fly   308 DAIGVRVNNTLSFLAINRKLASIWNNLCG----EKHPLISPGAVV--KSTQTKEIIAADNAKLSE 366
            ....||:|:..:|:.:||.:....|:|.|    ..|.::.|.|.:  |:|.....:..:.:::.:
plant   312 SKYFVRLNSIQAFMDVNRDVIGESNHLSGYSFSAHHNIVHPSAELGSKTTVGPHCMLGEGSQVGD 376

  Fly   367 KTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHRAQVKSGSVLKNCIIGPNYV 431
            |.|:..||.|.:|.|.....:.||::|.:|.:.:||:|...:|...||::....|::|.:...||
plant   377 KCSVKRSVIGRHCRIGSNVKIVNSVVMDHATIGDGCSIQGSVICSNAQLQERVTLRDCQVEAGYV 441

  Fly   432 VEEGT 436
            |..|:
plant   442 VCAGS 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	66/218 (30%)
		GCD1	5..441	CDD:224129	121/458 (26%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	23/80 (29%)
AT5G19485	NP_001031908.1	eIF-2B_gamma_N	3..220	CDD:133041	66/218 (30%)
		GCD1	4..442	CDD:224129	118/452 (26%)
		LbH_eIF2B_gamma_C	367..447	CDD:100057	23/80 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I3976
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7005
Inparanoid	1	1.050	150	1.000	Inparanoid score	I1712
OMA	1	1.010	-	-		QHG54649
OrthoDB	1	1.010	-	-		D1388750at2759
OrthoFinder	1	1.000	-	-		FOG0004788
OrthoInspector	1	1.000	-	-		oto4249
orthoMCL	1	0.900	-	-		OOG6_102755
Panther	1	1.100	-	-	LDO	PTHR45989
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840