Protein Alignment eIF2Bgamma and Gmppa

DIOPT Version :10

• Sequence 1: NP_611046.2
• Gene: eIF2Bgamma / 36722
• FlyBaseID: FBgn0034029
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: XP_552528.1
• Gene: Gmppa / 3291416
• VectorBaseID: AGAMI1_011043
• Length: 428
• Species: Anopheles gambiae
• Alignment Length: 472
• Identity: 91/472 - (19%)
• Similarity: 158/472 - (33%)
• Gaps: 181/472 - (38%)

  Fly     5 QAVVFAAG--RGTRLPEVLGDAPKCLLPVGPYPLI--------------------WYPLNLLQQ- 46
            :||:...|  :|||...:..|.||.|.||...|:|                    :||...:||
Mosquito     3 KAVILIGGPEKGTRFRPLSLDTPKPLFPVAGKPIIQHHVESCVRIKELKEILILGFYPATQMQQF 67

  Fly    47 ----HNFTEVIVVVLEQEKLEIQSALENTPLKLRLDYATIPSDGDFGTADSLRYIYDKIKSD--- 104
                .|..:|.:..|:          |.|.|               |||..:.:..|:|:|.
Mosquito    68 VSNMQNLYDVNIRYLQ----------EFTAL---------------GTAGGMYHFRDQIRSGNPG 107

  Fly   105 -FLVVSCDLVSNVSLYPLINKFREHDAALAMLLFPSGFESDVVMPGPKSKHKPERDLIGIHA--A 166
             |.|::.|:.::   :||...:..|                        :.|.|:.|:.|..  |
Mosquito   108 AFFVLNGDVCAD---FPLQELYDFH------------------------RSKNEKALVSIMGTEA 145

  Fly   167 TQRLAFVSAASDCEETLNIQRHLLKNRGRLDVYSRLVDAHVYVLKKWVIDYLRRKENISTFKGEF 231
            |::.|.........:...:..::.|.|..|   |.|::..|||..
Mosquito   146 TRQQAVHYGCLVLGKDEEVTHYVEKPRSYL---STLINCGVYVCS-------------------- 187

  Fly   232 LPHLIKKQHSKRPPKTVQDTTSEVGVV--TKNEDHVL------HYVGHTILDQKITQTSLFNQSL 288
                             .|..:::|.|  :|.:|:.:      ...||...:|:|.
Mosquito   188 -----------------MDIFAKMGAVFHSKQQDYSMLNNGNGKDSGHIQWEQEIL--------- 226

  Fly   289 SQSPYHGDIVRCYGIQAPRDAIGVRVNNTLSFLAINRKLASIWNNLCGEKHP--LISPGAVVKST 351
              :|..| ..:.|.:  |.:....::....|.:..||...:::.|    .||  |.|.|...::
Mosquito   227 --TPLAG-TGKLYAL--PVNNWWSQIKTAGSAIYANRHYLALYKN----AHPERLASAGLKTEN- 281

  Fly   352 QTKEIIAADNAKL------------------SEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIV 398
                    |||.|                  :.....|.|: ||..:|.|...|..|:|:.||::
Mosquito   282 --------DNANLVCNIVPDVHIHPTASVHPTATLGPNVSI-GPGVVIGPGVRVRESIILENAVI 337

  Fly   399 EEGCNIDNCIIGHRAQV 415
            ::...:.:.|:|..:|:
Mosquito   338 KDHSLVLHSIVGRGSQI 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	51/242 (21%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	18/77 (23%)
Gmppa	XP_552528.1	M1P_guanylylT_A_like_N	4..260	CDD:133050	67/361 (19%)
		LbetaH	296..362	CDD:469633	14/60 (23%)