Protein Alignment eIF2Bgamma and GMPPA

DIOPT Version :10

• Sequence 1: NP_611046.2
• Gene: eIF2Bgamma / 36722
• FlyBaseID: FBgn0034029
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: XP_047299979.1
• Gene: GMPPA / 29926
• HGNCID: 22923
• Length: 478
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 108/552 - (19%)
• Similarity: 189/552 - (34%)
• Gaps: 192/552 - (34%)

  Fly     5 QAVVFAAG--RGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQ-HNFTEVIVVVLEQEKLEIQS 66
            :||:...|  :|||...:..:.||.|.||...|:|.:.:....| ....|::::...|....:..
Human     3 KAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEPLTQ 67

  Fly    67 ALE------NTPLKLRLDYATIPSDGDFGTADSLRYIYDKIKSD----FLVVSCDLVSNVSLYPL 121
            .||      |.|::...::|.:      ||...|.:..|:|.:.    |.|::.|:.|:..|..:
Human    68 FLEAAQQEFNLPVRYLQEFAPL------GTGGGLYHFRDQILAGSPEAFFVLNADVCSDFPLSAM 126

  Fly   122 INKFRE-----------------------------HDAALAMLLFPSGFESDVVMPG-----PKS 152
            :...|.                             |: .|..:..||.|.||::..|     |::
Human   127 LEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHE-VLHYVEKPSTFISDIINCGIYLFSPEA 190

  Fly   153 KHKPERDLI------------------GI--HAATQRL---AFVSAASDCEETLNIQRHL----- 189
            . ||.||:.                  |:  .|.|.||   .|.:.|...:    |..||
Human   191 L-KPLRDVFQRNQQDGQFCLALGEDSPGLWPGAGTIRLEQDVFSALAGQGQ----IYVHLTDGIW 250

  Fly   190 --LKNRGRLDVYSRLV-----DAHVYVLKK------WVIDYLRRKENISTFKGEFLPHLIKKQHS 241
              :|:.|.....|||.     |.|...|.|      |:             :|        .|.:
Human   251 SQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWI-------------RG--------TQPA 294

  Fly   242 KRPPKTVQDTTSEVGVVTKNEDHVLHYVGHTILDQKITQTSLFNQSLSQSPYHGDIVRCYGIQAP 306
            ..|...:....||.|.:|.:.:                   |..|||...    |.:| :||.||
Human   295 PIPNLWLPPQPSEPGFLTSSPE-------------------LKPQSLPLP----DQIR-FGIFAP 335

  Fly   307 RDAIGVRVNNTLSFLAINRKLASIWNNLCGEKHPL--ISPGAVV-------------KSTQTKEI 356
            |.::.:..|..:                    ||.  ::|.||:             :..:.:|.
Human   336 RASLLLLGNVYI--------------------HPTAKVAPSAVLGPNVSIGKGVTVGEGVRLRES 380

  Fly   357 IAADNAKLSEKTSLNFSVFGPNCII--------SPKNIVAN---SLIMSNAIVEEGCNIDN-CII 409
            |....|.|.|.|.:..|:.|....:        :|.:...|   :.:.|.::.::|..:.. .|:
Human   381 IVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPNPNDPRARMDSESLFKDGKLLPAITIL 445

  Fly   410 GHRAQVKSGSVLKNCIIGPNYVVEEGTHSQAV 441
            |.|.::.:..::.|.|:.|:..:.....:|.:
Human   446 GCRVRIPAEVLILNSIVLPHKELSRSFTNQII 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	65/297 (22%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	17/91 (19%)
GMPPA	XP_047299979.1	M1P_guanylylT_A_like_N	4..266	CDD:133050	59/273 (22%)
		LbetaH	347..413	CDD:469633	13/85 (15%)