Protein Alignment eIF2Bgamma and eif-2Bgamma

DIOPT Version :9

• Sequence 1: NP_611046.2
• Gene: eIF2Bgamma / 36722
• FlyBaseID: FBgn0034029
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_495428.1
• Gene: eif-2Bgamma / 174138
• WormBaseID: WBGene00004090
• Length: 404
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 116/459 - (25%)
• Similarity: 201/459 - (43%)
• Gaps: 87/459 - (18%)

  Fly     1 MTEFQAVVFAAGRGTRLPEVLGDAPKCLLPVGPYPLIWYPLNLLQQHNFTEVIVVVLEQEKLEIQ 65
            |.|.|.::..:|.|||:|.:.....||||||...|:..|||:.|.:...|::.:.|.|..:|.::
 Worm     1 MHEMQGILLCSGGGTRMPVLTRHVQKCLLPVVGVPMFLYPLSSLLRTGITDIKIFVREVLQLTLE 65

  Fly    66 SALENTPL----KLRLDYATIPSDGDFGTADSLRYIYDKIKSDFLVVSCDLVSNVSLYPLINKFR 126
            ..::.:.|    ...::|..:..: ||||||.|:..:.||..|.|:||||.:|:.||.||::.||
 Worm    66 KEVKKSKLLEKYPAHIEYICVNQE-DFGTADLLKNHHSKITKDALIVSCDFISDASLIPLVDFFR 129

  Fly   127 EHDAALAMLLFPSGFESDVVMPGPKSKHKPERDLIGIHAATQRLAFVSAASDCEETLNIQRHLLK 191
            ..::.|..|:..:...:..  ||.|||.....|::.|..:|.:|||:....|.:..|.:::. ||
 Worm   130 ATNSTLVALIADTCVNAPA--PGSKSKKPKATDVMAIVESTGQLAFLCGDDDFDAPLVMEKS-LK 191

  Fly   192 NRGRLDVYSRLVDAHVYVLKKWVIDYLRRKENISTFKGEFLPHLIKKQHSKRPPKTVQDTTSEVG 256
            ....:.:.|:..|.|||.::..|:..|.:.::||:||.:|:|.||.||..
 Worm   192 IFPSIKLTSKYNDCHVYAIRHKVLLNLSKSKHISSFKADFVPLLIDKQFE--------------- 241

  Fly   257 VVTKNEDHVLHYVGHTILDQKITQTSLFNQSLSQSPYHGDIVRCYGIQAPRDAIGVRVN-NTL-S 319
               .:.|                                  ::|:..:.|.:...|..: ||| |
 Worm   242 ---PDSD----------------------------------IKCFAYRLPHENGFVTAHANTLGS 269

  Fly   320 FLAINRKLASIWNNL-----------------CGEKHPLISPGAVVKSTQTKEIIAADNAKLSEK 367
            :..:|:.:...:..|                 ...:..:.....:.|.:..|....:||.::.||
 Worm   270 YFEVNKAIQKSFTRLMEYRGNGKNFNYKTDKIAAHESRIEESAEIDKDSVIKRSFISDNCRIGEK 334

  Fly   368 TSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHRAQVKS-GSVLKNCIIGPNYV 431
            |.|..|:.....:|.....::||:|.....:.|..::.|||:....:|.: |.|       .|.|
 Worm   335 TKLKESIIAKGVVIGNGASISNSIICDGVEIGENADVTNCIVAKDQKVPAKGKV-------QNEV 392

  Fly   432 VEEG 435
            ||:|
 Worm   393 VEDG 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bgamma	NP_611046.2	eIF-2B_gamma_N	4..215	CDD:133041	67/214 (31%)
		GCD1	5..441	CDD:224129	114/455 (25%)
		LbH_eIF2B_gamma_C	357..437	CDD:100057	23/80 (29%)
eif-2Bgamma	NP_495428.1	GCD1	3..388	CDD:224129	109/440 (25%)
		eIF-2B_gamma_N	4..215	CDD:133041	67/214 (31%)
		LbH_G1P_AT_C_like	307..384	CDD:100046	18/76 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159124
Domainoid	1	1.000	83	1.000	Domainoid score	I5361
eggNOG	1	0.900	-	-		E1_COG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7005
Inparanoid	1	1.050	144	1.000	Inparanoid score	I3038
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54649
OrthoDB	1	1.010	-	-		D1388750at2759
OrthoFinder	1	1.000	-	-		FOG0004788
OrthoInspector	1	1.000	-	-		oto19862
orthoMCL	1	0.900	-	-		OOG6_102755
Panther	1	1.100	-	-	LDO	PTHR45989
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R375
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800