DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8187 and FAM185A

DIOPT Version :9

Sequence 1:	NP_611045.1	Gene:	CG8187 / 36720	FlyBaseID:	FBgn0034027	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001138740.2	Gene:	FAM185A / 222234	HGNCID:	22412	Length:	392	Species:	Homo sapiens

Alignment Length:	335	Identity:	80/335 - (23%)
Similarity:	154/335 - (45%)	Gaps:	32/335 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VNPFARINVKSDVFLRIQPADVHQYTSGDVFIAQLVG--GHVKNSNVSLDVKVTDEDKVVNVVVK 107
            |:||.|:..:....|.::|.|...|..||..:..:.|  |.|:..: .|.||. |||.....:|.
Human    71 VSPFGRLRARLPCHLAVRPLDPLTYPDGDRVLVAVCGVEGGVRGLD-GLQVKY-DEDLEEMAIVS 133

  Fly   108 QLAEQPSKLECHLQIPVRSDVSVDAKGSVRVEGIQSELLQVKAKEGI-LTKNIKATHINLYSENG 171
            ......:.:|.:..:....|:.....|.|:|:.|:.:..:::.:.|. :.:::|...:::.::.|
Human   134 DTIHPQASVEVNAPLKFGLDIKSSGSGCVKVQSIEGDNCKIETEHGTSILQSVKGQKLHVQTKGG 198

  Fly   172 NINCQGTLLGKITQIESQNGNIAMDKLQGDSLNCSTKAGSIVTDCCYVEKSKFQTQTGRLELKNV 236
            .:.|.||:.|.|....|....:.:|||||.|:..||:.|.:.....|.|.|...:..|.:.|.:|
Human   199 KVICLGTVYGNIDIHASDKSAVTIDKLQGSSVTVSTEDGLLKAKYLYTESSFLSSAAGDITLGSV 263

  Fly   237 H-------KSSEVHVHQSSDLNMTGVHGNIQITTKGGNLNVQLSELVGSNKIDAENLLEEAIIHI 294
            |       |...:.|..||        |.::.:|..|.::|.:|:|   .|::.::.....|:.:
Human   264 HGNITLQSKMGNITVDSSS--------GCLKASTNQGAIDVYVSQL---GKVELKSHKGSIIVKV 317

  Fly   295 SQAIEQNLHIEVTAPEVKLENELEHVAHALNESKNKFV----LSNPNTNRLE-VSSTGDKG-VRL 353
            ..:::  .|::::..||.:.:|: ||.......|:..|    |.|..:.|.: :.:...|| |..
Human   318 PSSLQ--AHLQLSGKEVDVNSEV-HVQEMAEVRKDDVVTVTGLMNQASKREKWIKADAPKGTVSF 379

  Fly   354 GKQSWSDMMR 363
            .:|||...::
Human   380 RRQSWFQSLK 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8187	NP_611045.1	DUF4097	<185..>283	CDD:290087	28/104 (27%)
FAM185A	NP_001138740.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..60
FAM185A	NP_001138740.2	DUF4097	<185..336	CDD:315916	39/163 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147934
Domainoid	1	1.000	54	1.000	Domainoid score	I11318
eggNOG	1	0.900	-	-		E1_2BX0G
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I5059
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47491
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008113
OrthoInspector	1	1.000	-	-		oto90822
orthoMCL	1	0.900	-	-		OOG6_108107
Panther	1	1.100	-	-	LDO	PTHR34094
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5117
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790