DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITGA1 and if

DIOPT Version :9

Sequence 1:NP_852478.1 Gene:ITGA1 / 3672 HGNCID:6134 Length:1179 Species:Homo sapiens
Sequence 2:NP_001162777.1 Gene:if / 32661 FlyBaseID:FBgn0001250 Length:1396 Species:Drosophila melanogaster


Alignment Length:1225 Identity:262/1225 - (21%)
Similarity:430/1225 - (35%) Gaps:409/1225 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    18 LLTVVLRCCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGKWVLIG-----SPLVGQPK---- 73
            :|.::......:|:|:.:.:.|......|||:::..::...|   ..|     |.:||.||    
  Fly    21 ILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSG---FYGNQNNVSLIVGAPKFDTS 82

Human    74 ------NRTGDVYKCPVGRGESLPCVKLDLPVNTSIPN------VTEVKENMTFGSTLVTNPNGG 126
                  ...|.|:||.:...:   | || :|.::...|      |.:.|.....|:|:.|..:..
  Fly    83 RYQQGVTEAGGVFKCSLNDDD---C-KL-VPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSD 142

Human   127 F-LACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQLDIVIVLDGSNSIYPWDSVT 190
            . :||.|.|.:     |..|     .|..|:    |.||..|.|                     
  Fly   143 LVVACAPRYVF-----HTMT-----PSRAFR----IDPVGTCFT--------------------- 172

Human   191 AFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGID 255
                                        :|.|                                 
  Fly   173 ----------------------------SHNF--------------------------------- 176

Human   256 TARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLST 320
                |.|.|                             :..|...|        .|.:.:|:   
  Fly   177 ----EEFYE-----------------------------VSPCRTNN--------WGYHRQGS--- 197

Human   321 EKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFSAH 385
                                                                     .|.||||.
  Fly   198 ---------------------------------------------------------CQAGFSAA 205

Human   386 YSQDW--VMLGAVGAYDWN----------------------GTVVMQKASQIIIPRNTTFNV-ES 425
            .:.:.  :.:||.|::.|.                      ||..|..:..:..|.|..|:. ||
  Fly   206 INGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSES 270

Human   426 TKKNEPLASYLGYTVNSATAS---SGDVLYIAGQPR-YNHTGQVIIYRMEDGNIKILQTLSGEQI 486
            ...|:.  |||||::.:....   |.||  ..|.|| .|..|::::.|....||   ..::|.||
  Fly   271 ASVNDD--SYLGYSMVTGDFDGDRSEDV--AIGMPRGGNLVGRIVVNRWNMANI---FNITGRQI 328

Human   487 GSYFGSILTTTDIDKDSNTDILLVGAPMYMGTE----KEEQGKVYVYALNQTRFEYQMSLEPIKQ 547
            |.|||..|.|:|:|.| ..|.||:|||||...:    |.:.|:||:........|.:.:.|.|:.
  Fly   329 GEYFGYSLATSDVDGD-GLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRD 392

Human   548 TCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHG-GAVYIYHGS-- 609
            ...|.                .|||.|:..:.|:|.||:.|..:|||.:...| |.|||:|||  
  Fly   393 GYHSK----------------GRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPM 441

Human   610 ------GKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGG--AALFWSRD 666
                  .:.|:.|  |.:......:|   ||.::.|.:|::|:...|:.:|....  ..:|.||.
  Fly   442 GPLAKPSQIIKSE--QLVEGAPYPRT---FGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRP 501

Human   667 VAVVKVTMNFEPNK--VNIQKKNCHM--EGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLD 727
            ||.|....:|..|.  :::..::|.:  :.|:..|:..|.|:....:...:   :.|......||
  Fly   502 VAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPE---QLDFDVSWLLD 563

Human   728 SLRQISRSFFSGTQERKVQRNITVR----KSECTKHSFYMLDK-HDFQDSVRITLDFNL-----T 782
            :.:.::...|....|.|..||.|:|    :..|...:.|:||| .|....:.:...:||     .
  Fly   564 AKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPL 628

Human   783 DP---------ENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDK 838
            ||         |  ||:|.:....:.:.|...|:||....|..||.|.|:|.:|.|.   ...:.
  Fly   629 DPMVRHRRSILE--PVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLF---GSPEP 688

Human   839 FNVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAI--QKD---SC-----ESNHNITCKVGYPFL 893
            ..:.:.:.||.:.|:.....:...|:|.|..::.:  :||   :|     |:||.:.|.:|.| |
  Fly   689 LVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNP-L 752

Human   894 RRGEMVTFKI------LFQFNTSYLMENVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQF 952
            ..|::..|||      .:..::||     ..|..|.|.:.|.|.:..||.:..|:.:..:..|..
  Fly   753 ESGKIAHFKISLVPEEKYGSSSSY-----DFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDI 812

Human   953 Y-SSASEYHISIAANETVPEVINST--EDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGY 1014
            . :|..:|.:..|  :...|:.|:|  :|||.::...|.||.:....:.|.::.|..|..|..|.
  Fly   813 KGTSLPDYQLYKA--DDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGD 875

Human  1015 PVLYPTGLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDI 1079
            |::|               :...|   .:|.|                       |.|:    |:
  Fly   876 PLMY---------------LLNQP---ETGGK-----------------------IQCD----DV 895

Human  1080 SQVNVSLILWKPTFIKSYFSSLNLTIRGEL-RSENASLVLSSSNQKRELAIQISK 1133
            :....:|:|.:....|||     |..:|.: .|...|...|||:.....::.|.|
  Fly   896 AFNEYNLLLDEKLVKKSY-----LQAQGAIWNSAQVSGQSSSSSSSGGASVHIEK 945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGA1NP_852478.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 30..91 17/75 (23%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..160 14/65 (22%)
vWA_integrins_alpha_subunit 171..351 CDD:238746 9/179 (5%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 365..417 12/75 (16%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 422..475 17/57 (30%)
Int_alpha 434..474 CDD:214549 14/43 (33%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 476..538 24/65 (37%)
Int_alpha 486..>529 CDD:214549 22/46 (48%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 557..615 21/66 (32%)
Int_alpha 568..621 CDD:214549 23/61 (38%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 619..679 16/61 (26%)
Integrin_alpha2 664..1056 CDD:285619 101/433 (23%)
GFFKR motif 1167..1171
ifNP_001162777.1 Int_alpha 46..110 CDD:214549 18/71 (25%)
Int_alpha 275..>316 CDD:214549 14/44 (32%)
Int_alpha 398..451 CDD:214549 20/52 (38%)
Int_alpha 466..>497 CDD:214549 7/30 (23%)
Integrin_alpha2 499..893 CDD:285619 102/450 (23%)
DUF2756 <1120..1178 CDD:298627
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142035
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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