DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KIF14

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_055690.1	Gene:	KIF14 / 9928	HGNCID:	19181	Length:	1648	Species:	Homo sapiens

Alignment Length:	1351	Identity:	394/1351 - (29%)
Similarity:	607/1351 - (44%)	Gaps:	286/1351 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPED 67
            :.::.||||||||.:||.......:|.|..::..:::|      :.||...|.:|..|:|.:...
Human   356 NSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHP------DTKQVYNFIYDVSFWSFDECH 414

  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132
            .::|||.||::.:...:|:.||:|:|.|:||||||||||||||||..|..|||||.|:.|||.:|
Human   415 PHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFSQVA 479

  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPK----PNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            .|.|.|:.|.:|:|:.|:||||:||||..|    ..||.|:||||.|.||||:.||...|:||.|
Human   480 RKQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYAD 544

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEK-----VSRMSLVDLAG 253
            |.:.:..|||.|..|||.||.:|||||:||::|:||..|:   .|.||:     .||::|:||||
Human   545 IQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTE---FVEGEEHDHRITSRINLIDLAG 606

  Fly   254 SERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLG 318
            |||.......|||||||.:|||||.|||.|||.|::|:|.:    ..|:|||:||||||||::||
Human   607 SERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQR----SVFIPYRESVLTWLLKESLG 667

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||:|.|:|||||:|.|.||||||||||::|:.|||.|.||||.||::||||:.|:..|::..::
Human   668 GNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRN 732

  Fly   384 ATG----------SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS 438
            :..          ..:..::.||.:.|..|.::.:.|:||..:.|:.:.:..:.|:|.||..|
Human   733 SRNIDPERYRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQ-- 795

  Fly   439 GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDS 503
               ::.:...|||||.||.|:|:|:|.:|:.|...|:.......||||||:.|..:||.|.....
Human   796 ---MDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGG 857

  Fly   504 GLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQ--LI 566
            .:.:.||..|:.:|||...:|.|.|::|||::.|..|:||.|.|.........|...||..  ..
Human   858 TVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPK 922

  Fly   567 DYNFARDEIM---------------------------------QNELSND--PIQTAIARLERQH 596
            |:.||::|::                                 |.|||:.  ..::.|..||.:.
Human   923 DFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAEL 987

  Fly   597 EEDKQ----------------VALEKQRQEYERQFQQLRNILSPSTPYAPYAPYD-PLRMGKITP 644
            .|:.|                ..|||.:|..|::....:..|...|.....|..| .:|..:|..
Human   988 REESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILE 1052

  Fly   645 NTPTSQMRVEKWAQ-------ERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTL 702
            ...|.:.::.|..|       .||:.|   ..|.....|:.:.::||||.::.:::....|.
Human  1053 ALETEKQKIAKEVQILQQNRNNRDKTF---TVQTTWSSMKLSMMIQEANAISSKLKTYYVFG--- 1111

  Fly   703 QIPPANLSPNRRRGAFVSEPAILVKRTNSG-SQIWTMEKLENKLIDMREMYQEHKERVLNGLD-- 764
               ..::|....     |:.:|.|:....| |..|::||.|:||..|:|:|:.:...  .|.|
Human  1112 ---RHDISDKSS-----SDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSN--RGEDAF 1166

  Fly   765 ---EDNAKPQ--DPFYES---------QENHNLIGVANIFLEVLFHDVK----------LDYHTP 805
               ||..:|.  |....|         .:|..:.|..:   ::..|.:|          :|..:.
Human  1167 CDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGCLH---DIQVHPIKNLHSSHSSGLMDKSST 1228

  Fly   806 IISQQGE----------------VAGRLQVEIERIA------------GQMPQDRMCESVSESSG 842
            |.|...|                ..|:...|...||            |.....:..|...|.|.
Human  1229 IYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQ 1293

  Fly   843 DSRDEYDDPVDPTSNQITCR-----VTIK--------CAS------------------------G 870
            |:....|..:...:.|..|.     |.:|        |.:                        |
Human  1294 DNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQG 1358

  Fly   871 LPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFK------FEHTQDFTVTINEEFLEHC 929
            ..|.:|:.:      ...|:..:.::........|..|.|      .|:..:...::.|||::..
Human  1359 CCLDISSMI------KEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAV 1417

  Fly   930 IEG-ALSIEVWGHRSAGFSK------------TKGWEVEQQQAKA----RSLVDRWAE-----LS 972
            .:| .|.:::.  ..:|..|            ||....::.:..|    |||.:.:||     ..
Human  1418 CDGVGLGMKIL--LDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFR 1480

  Fly   973 RKIELWVEIHELNDNGEYSPVE--VTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQ 1035
            |:::        .:|.||...:  |....|.|     :|:...::.:.:.:..::.       |.
Human  1481 RQVQ--------EENFEYQDFKRMVNRAPEFL-----KLKHCLEKAIEIIISALKG-------CH 1525

  Fly  1036 SIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIK-------KEE 1093
            |.:|:.  ...|.|......|.|  .|.:|..........|....:.|:::.|.|       .||
Human  1526 SDINLL--QTCVESIRNLASDFY--SDFSVPSTSVGSYESRVTHIVHQELESLAKSLLFCFESEE 1586

  Fly  1094 KNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPH 1144
            ..:        |:..|.:..:........:..|||.|:.....|....|.|
Human  1587 SPD--------LLKPWETYNQNTKEEHQQSKSSGIDGSKNKGVPKRVYELH 1629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	187/363 (52%)
		KISc	6..359	CDD:214526	187/361 (52%)
		Kinesin_assoc	356..468	CDD:292801	37/121 (31%)
		FHA	446..546	CDD:238017	40/99 (40%)
		KIF1B	741..786	CDD:289208	14/60 (23%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
KIF14	NP_055690.1	Required for PRC1-binding	1..356		394/1351 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Required for microtubule-binding with high affinity. /evidence=ECO:0000250\|UniProtKB:L0N7N1	356..737		199/393 (51%)
		KISc_KIF1A_KIF1B	357..708	CDD:276816	187/363 (52%)
		KISc	358..708	CDD:214526	187/362 (52%)
		Kinesin_assoc	705..823	CDD:292801	38/122 (31%)
		FHA	803..900	CDD:238017	40/96 (42%)
		Required for CIT-binding	901..1648		141/788 (18%)
		YlqD	962..>1022	CDD:287979	14/59 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1648		7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920