DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and SMY1

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_012844.1	Gene:	SMY1 / 853783	SGDID:	S000001562	Length:	656	Species:	Saccharomyces cerevisiae

Alignment Length:	621	Identity:	157/621 - (25%)
Similarity:	260/621 - (41%)	Gaps:	161/621 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QQTIL-QNPPPLEKIERKQPKTFAFDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACI 96
            :.|:| :...||.:..::...||.||..|      |.| |:||.|...:...|:::...|||..:
Yeast    53 ENTVLFRTNNPLHETTKETHSTFQFDKVF------DAN-ATQEDVQKFLVHPIINDVLNGYNGTV 110

  Fly    97 FAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAI-ANKSTPELMYKVEVSYMEIYNEKVHDLLD 160
            ..||.:.|||||:::|::||:||:|.:|..||..: .|:.|....:.|.|...|||.||.:|||.
Yeast   111 ITYGPSFSGKSYSLIGSKESEGILPNICKTLFDTLEKNEETKGDSFSVSVLAFEIYMEKTYDLLV 175

  Fly   161 PKPNKQSLKV-REHNVMGPYVDGLSQLAVTSYQD----IDNLMTEGNKSRTVAATNMNAESSRSH 220
            |.|.::.||: |..:.|...:..:....|.||:|    |..:...||:    .|.....|.||||
Yeast   176 PLPERKPLKLHRSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQNVGNR----MACGDKTERSRSH 236

  Fly   221 AVFSVVLTQ------ILTDQATGVSGEKVSRMSLVDLAGSE---RAVKTGAVGDRLKEGSNINKS 276
            .||.:.:.|      ||          |.|.:.||||.|:|   :..::....|.||:   :|:|
Yeast   237 LVFQLHVEQRNRKDDIL----------KNSSLYLVDLHGAEKFDKRTESTLSQDALKK---LNQS 288

  Fly   277 LTTLGLVISKLA----DQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYE 337
            :..|...:..|:    |.:...|..:..  .||:|.||.:|||:||||.:|.::.|...|  |..
Yeast   289 IEALKNTVRSLSMKERDSAYSAKGSHSS--AYRESQLTEVLKDSLGGNRKTKVILTCFLS--NVP 349

  Fly   338 ETLSTLRYADRAKRIVNHAV--------------------VNEDPNARIIRELRHEVETLRSMLK 382
            .|||||.:.|..::|.|...                    :.:|.....|..|:.|:::|:|:
Yeast   350 TTLSTLEFGDSIRQINNKVTDNTTGLNLKKKMDLFIQDMKIKDDNYVAQINILKAEIDSLKSL-- 412

  Fly   383 HATGSPVGDVQDKLAES---ENL------------------------------------MKQISQ 408
            |....|..| :.|:.|:   ||:                                    .:||:|
Yeast   413 HNKSLPEDD-EKKMLENTKKENIKLKLQLDSITQLLSSSTNEDPNNRIDEEVSEILTKRCEQIAQ 476

  Fly   409 ---TWEEKLVKTERIQNE------RQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVY 464
               :::.::....::|.|      :::|||.|.:.:.......|:....|:..||      :|..
Yeast   477 LELSFDRQMNSNSKLQQELEYKKSKEEALESMNVRLLEQIQLQEREIQELLTTNA------ILKG 535

  Fly   465 YLKDRTLIGG------RTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAV 523
            .|:..|.:..      :::.....::.|:...|.               .|.:|:....:|:..:
Yeast   536 ELETHTKLTETRSERIKSLESSVKELSLNKSAIP---------------SPRRGSMSSSSGNTML 585

  Fly   524 EKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEP 559
            .   ::.|..|         .|||.|.|||   |:|
Yeast   586 H---IEEGSEI---------SNSPWSANTS---SKP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	112/365 (31%)
		KISc	6..359	CDD:214526	112/365 (31%)
		Kinesin_assoc	356..468	CDD:292801	28/179 (16%)
		FHA	446..546	CDD:238017	13/105 (12%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
SMY1	NP_012844.1	KISc_KHC_KIF5	25..364	CDD:276820	110/338 (33%)
SMY1	NP_012844.1	Smc	<254..568	CDD:224117	71/329 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910