DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and AT4G38950

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001119143.1	Gene:	AT4G38950 / 830050	AraportID:	AT4G38950	Length:	836	Species:	Arabidopsis thaliana

Alignment Length:	723	Identity:	186/723 - (25%)
Similarity:	304/723 - (42%)	Gaps:	177/723 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKIKVAVRVRPFNRREI----ELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLN 64
            :||.|.||:||.|::||    ..|.:||    ...|||......|  ....|..::||..:....
plant    12 EKILVLVRLRPLNQKEIAANEAADWECI----NDTTILYRNTLRE--GSNFPSAYSFDKVYRGEC 70

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFS 129
            |..:       |::...:.|..:..:|.|..|||||||.|||:|||.|..|.  .:..:.|.:|
plant    71 PTRQ-------VYEDGTKEIALSVVKGINCSIFAYGQTSSGKTYTMTGITEF--AVADIFDYIF- 125

  Fly   130 AIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDI 194
                 ...|..:.|:.|.:|||||.:.|||  ..:..||::|:....|..|:..::..:..:..:
plant   126 -----QHEERAFSVKFSAIEIYNEAIRDLL--SSDGTSLRLRDDPEKGTVVEKATEETLRDWNHL 183

  Fly   195 DNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEK-----VSRMSLVDLAGS 254
            ..|::.....|.:..|::|..|||||.:..:.    :...|....|::     ::.::.:|||||
plant   184 KELLSICEAQRKIGETSLNERSSRSHQMIRLT----VESSAREFLGKENSTTLMASVNFIDLAGS 244

  Fly   255 ERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGG 319
            |||.:..:.|.|||||.:||:||.|||.||.||:       .|....:.:|||.||.:|:..|||
plant   245 ERASQAMSAGTRLKEGCHINRSLLTLGTVIRKLS-------KGRQGHINFRDSKLTRILQPCLGG 302

  Fly   320 NSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNAR-IIRELRHEVETLRSMLKH 383
            |:||.::.|:||:..:.|.|.:||.:|..||.:...|.:|...:.: ::::|:.|:..|.:.|::
plant   303 NARTAIICTLSPARSHVELTKNTLLFACCAKEVTTKARINVVMSDKALLKQLQRELARLETELRN 367

  Fly   384 ATGSPVGDV-------------------------QDKLAES--ENLMKQI--------------- 406
            ...||..:.                         |..||:|  |:.|:.|
plant   368 PASSPASNCDCAMTVRKKDLQIQKMEKEIAELRKQRDLAQSRLEDFMRMIEHNVASKPGTPHFGN 432

  Fly   407 -SQTWEEKLV-KTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDR 469
             :..||:..| :|..:.:..:::....|:|...|     .::.|:.:.:.|..|:|.|....:|
plant   433 HTDKWEDGSVSETSGVVDSDRRSFISDGMSTPLS-----ISRAYVHSHSDDDDLDEDLPRRSED- 491

  Fly   470 TLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLY-------MEP--VQGARCFVNGSAAVEK 525
                            ||....:...|:.|.|...:|       .||  |.|.....||..:|.:
plant   492 ----------------LSEEYCREVQCIETEESVTVYNNKKDKRAEPENVLGCGEDANGETSVSQ 540

  Fly   526 -----------------TPLQNGDRILWGNHHFFRVNSPK-------SNNTSM--CASEP----- 559
                             ||.:|......|.....::..|.       |.|.||  |.|:.
plant   541 NVRVRSWNRRETVSGPSTPPENIGTGFLGRPESHKIAFPDLEFGSTVSRNDSMSSCGSDSTGTQS 605

  Fly   560 -QTPAQLIDYNFARDEIMQNELSNDPIQTAIARL----ERQHE----ED-----KQVALEKQRQE 610
             :||             :..|.....|:|.:..|    :||.|    ||     :.:.|:...:|
plant   606 IRTP-------------LGEEGGITSIRTFVEGLKEMAKRQGEVSNAEDSGKMRRDIGLDSMDRE 657

  Fly   611 YERQFQQL 618
            :|||.|::
plant   658 FERQRQEI 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	118/363 (33%)
		KISc	6..359	CDD:214526	117/361 (32%)
		Kinesin_assoc	356..468	CDD:292801	27/156 (17%)
		FHA	446..546	CDD:238017	23/125 (18%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
AT4G38950	NP_001119143.1	KISc_CENP_E	13..335	CDD:276825	117/355 (33%)
		DUF4175	<349..>419	CDD:372724	13/69 (19%)
		DUF3490	658..816	CDD:371840	4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910