DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and PAKRP1

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_567423.1	Gene:	PAKRP1 / 827054	AraportID:	AT4G14150	Length:	1292	Species:	Arabidopsis thaliana

Alignment Length:	1332	Identity:	319/1332 - (23%)
Similarity:	541/1332 - (40%)	Gaps:	366/1332 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVE-MEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDEN 69
            :||.||::|.|:.|   :...||| |.|....:..            :||.||..   .|||
plant    92 VKVIVRMKPLNKGE---EGDMIVEKMSKDSLTVSG------------QTFTFDSI---ANPE--- 135

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQ----------ESKGIIPRLC 124
             ::||.:|..||..:::|...|:|:.:||||||||||:|||.|..          :.:|:.||:.
plant   136 -STQEQMFQLVGAPLVENCLSGFNSSVFAYGQTGSGKTYTMWGPANGLLEEHLCGDQRGLTPRVF 199

  Fly   125 DQLFSAIANKSTP----ELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQ 185
            ::||:.|..:...    :|.|:...|.:|||||::.||||  |::::|.:||....|.||:.|::
plant   200 ERLFARIKEEQVKHAERQLNYQCRCSLLEIYNEQITDLLD--PSQKNLMIREDVKSGVYVENLTE 262

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            ..|.:..|:..|:.:|..:|...||::|.||||||.||:.|:.....:.|.|:|..|.||::|||
plant   263 EYVKNLTDVSQLLIKGLGNRRTGATSVNTESSRSHCVFTCVVESRCKNVADGLSSFKTSRINLVD 327

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            ||||||...|||.|:||||..|||:||:.||.:|:.||:.|   ::|..:.:|||||.||:||::
plant   328 LAGSERQKSTGAAGERLKEAGNINRSLSQLGNLINILAEIS---QTGKPRHIPYRDSRLTFLLQE 389

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNE----DPN--ARIIRELRHEV 374
            :||||::..||..:|||.....||.||||:|.|||.|.|.|||||    |.|  ..:|.:||.|:
plant   390 SLGGNAKLAMVCAVSPSQSCRSETFSTLRFAQRAKAIQNKAVVNEVMQDDVNFLRGVIHQLRDEL 454

  Fly   375 E---------------------------TLRSM-LKHATGSP----VGDVQDKLAES--ENLMKQ 405
            :                           .|||. |.|....|    .||::.::.|:  |.|..|
plant   455 QRMKNDGNNPTNPNVAYSTAWNARRSLNLLRSFGLGHPRSLPHEDNDGDIEMEIDEAAVERLCVQ 519

  Fly   406 I-------------------------SQTWEEKLVKTERI---------QNERQQALEKMGISVQ 436
            :                         .|:.|::|.:...:         :|...:.::.|....:
plant   520 VGLQSSLASEGINHDMNRVKSIHSSDGQSIEKRLPEDSDVAMEDACCHTENHEPETVDNMRTETE 584

  Fly   437 ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDI---------QLSGLGI- 491
             :||:..:.|.:...|:.:.|...|.|......:|.....:| ..||:         .|...|:
plant   585 -TGIRENQIKTHSQTLDHESSFQPLSVKDALCSSLNKSEDVS-SCPDLVPQDVTSANVLIADGVD 647

  Fly   492 QPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNT--SM 554
            .|||.|.:...| |.::||        |:..|.|:|..:              .||...|:  |:
plant   648 DPEHLVNSASPS-LCIDPV--------GATPVLKSPTLS--------------VSPTIRNSRKSL 689

  Fly   555 CASEPQTPAQLIDYNFARDEIMQNELSN--DPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQ 617
            ..||..|.:|       :|...:|.::.  ||......::     .:...||..|:.:
plant   690 KTSELSTASQ-------KDSEGENLVTEAADPSPATSKKM-----NNCSSALSTQKSK------- 735

  Fly   618 LRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQ---ERDEMFRRSL----GQLKTDI 675
                            ..|:|..::..:.......:|.:.|   :|...:|.|.    .:..|.|
plant   736 ----------------VFPVRTERLASSLHKGIKLLESYCQSTAQRRSTYRFSFKAPDSEPSTSI 784

  Fly   676 MRANSLVQE---ANFLAEEMEK---------KTKFSV-------TLQIPP------ANLSPNRRR 715
            .:|::.||.   |:.::||..|         :.:|..       .||:.|      |..|.|:..
plant   785 SKADAGVQTIPGADAISEENTKEFLCCKCKCREQFDAQQMGDMPNLQLVPVDNSEVAEKSKNQVP 849

  Fly   716 GAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHK-ERVLNGL------DE-------- 765
            .|.....|..::|..:..:..|  |..:::..:..:.|::| ||..|.:      |:
plant   850 KAVEKVLAGSIRREMALEEFCT--KQASEITQLNRLVQQYKHERECNAIIGQTREDKIIRLESLM 912

  Fly   766 DNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKL-----DYHTPIISQQGEVAGRLQVEIERIA 825
            |....::.|.:.:            ...|.|:.||     ..|..::        :.::|:||..
plant   913 DGVLSKEDFLDEE------------FASLLHEHKLLKDMYQNHPEVL--------KTKIELERTQ 957

  Fly   826 GQMPQDRMCESVSESSGD--SRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGH 888
            .::      |:.....||  .|:...:.:.....|:.|.:.....|.|..       |......:
plant   958 EEV------ENFKNFYGDMGEREVLLEEIQDLKLQLQCYIDPSLKSALKT-------CTLLKLSY 1009

  Fly   889 QEMVVPVINAESTAHDQNMVFKFEH-----TQDFT--VTINEEFLEHCIEGALSIEVWGHRSAGF 946
            |   .|.:||...:.|:::....|.     |:..|  ::::|| |...:|.:.::..........
plant  1010 Q---APPVNAIPESQDESLEKTLEQERLCWTEAETKWISLSEE-LRTELEASKALINKQKHELEI 1070

  Fly   947 SKTKGWEVEQQQAKARS----LVDRWAELSRK-IELWVEIHELNDN------------------- 987
            .|..|.|:::....|..    :::::|:|..| ::|......:.|.
plant  1071 EKRCGEELKEAMQMAMEGHARMLEQYADLEEKHMQLLARHRRIQDGIDDVKKAAARAGVRGAESR 1135

  Fly   988 ------GEYSPVEVTNRNEVLTGGIYQLRQ-------GQQRRVNVRVKPVQNSGTLPIICQSIVN 1039
                  .|.|.::|....|         ||       ..|.::....:.:|.:|.|.:
plant  1136 FINALAAEISALKVEKEKE---------RQYLRDENKSLQTQLRDTAEAIQAAGELLV------- 1184

  Fly  1040 VAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELS 1104
                      ||:.     .||.|||.:::..:|        :.:.....::.:|.:::.|.|::
plant  1185 ----------RLKE-----AEEGLTVAQKRAMDA--------EYEAAEAYRQIDKLKKKHENEIN 1226

  Fly  1105 LVHQWVSLTEERNAVLVPAPGSGIPGAPASWE 1136
            .::|.|..:...|........:..|...||.|
plant  1227 TLNQLVPQSHIHNECSTKCDQAVEPSVNASSE 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	151/367 (41%)
		KISc	6..359	CDD:214526	151/367 (41%)
		Kinesin_assoc	356..468	CDD:292801	35/185 (19%)
		FHA	446..546	CDD:238017	23/109 (21%)
		KIF1B	741..786	CDD:289208	8/59 (14%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
PAKRP1	NP_567423.1	PLN03188	2..1292	CDD:215621	319/1332 (24%)
		Motor_domain	92..434	CDD:277568	152/368 (41%)
		Kinesin-relat_1	901..987	CDD:289481	15/111 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2548
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910