DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KINESIN-12B

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_189009.2	Gene:	KINESIN-12B / 821947	AraportID:	AT3G23670	Length:	1313	Species:	Arabidopsis thaliana

Alignment Length:	1480	Identity:	344/1480 - (23%)
Similarity:	568/1480 - (38%)	Gaps:	468/1480 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENF 70
            :||.||::|.::.|.|   :.||:......:..|           .:||.||..   .:||
plant    97 VKVIVRMKPPSKGEEE---EMIVKKISNDALTIN-----------EQTFTFDSI---ADPE---- 140

  Fly    71 ASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG----------TQESKGIIPRLCD 125
            ::|:.:|..||..:::|...|:|:.:||||||||||:|||.|          :.:.:|:.||:.:
plant   141 STQDEIFQLVGAPLVENCLAGFNSSVFAYGQTGSGKTYTMWGPANGLLEEHLSGDQRGLTPRVFE 205

  Fly   126 QLFSAI----ANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            .||:.:    |..:..:|.|:...|::|||||::.||||  |:.::|.:||....|.||:.|::.
plant   206 LLFARLSEEQAKHAERQLKYQCRCSFLEIYNEQITDLLD--PSLKNLMIREDVKSGVYVENLTEE 268

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDL 251
            .|.:.:|:..|:.:|..:|...||::||||||||.||:.|:.......|.|:|..|.||::||||
plant   269 YVKNLKDLSKLLVKGLANRRTGATSVNAESSRSHCVFTCVVESHCKSVADGLSSFKTSRINLVDL 333

  Fly   252 AGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDN 316
            |||||...|||.||||||..|||:||:.||.:|:.||:.|   ::|..:.:|||||.||:||:::
plant   334 AGSERQKLTGAAGDRLKEAGNINRSLSQLGNLINILAEIS---QTGKQRHIPYRDSRLTFLLQES 395

  Fly   317 LGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNE----DPN--ARIIRELRHEVE 375
            ||||::..||..:|||.....||.||||:|.|||.|.|.|:|||    |.|  ..:||:||.|::
plant   396 LGGNAKLAMVCAVSPSQSCRSETFSTLRFAQRAKAIQNKAIVNEVMQDDVNFLREVIRQLRDELQ 460

  Fly   376 ----------------------------TLRSM-LKHATGSPVGDVQDKLAESENLMKQISQTWE 411
                                        .|||. |.|....|.|| .|...|.|     |.:...
plant   461 RVKDDKGNNPTNPNAAYTTSWNARRSLSLLRSFGLGHPKSLPNGD-DDGDTEME-----IDEEAV 519

  Fly   412 EKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRT 476
            |:|             ..:||:|..|.....|.::...:|       :.|....|||.:......
plant   520 ERL-------------CAQMGLSPPAEDNNQEMSRVEKIN-------SSLQTVVLKDESYNNSHL 564

  Fly   477 ISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGS----AAVEKTPLQNGDRILWG 537
            .|.:..|:.:.....|.|:                      |||    |......:.:|..:
plant   565 KSSEATDVNMEDACCQTEN----------------------NGSETDNALTVAETMDDGSSV--- 604

  Fly   538 NHHFFRVNSPKS--NNTSMCASEP---QTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHE 597
                    .|.|  |:...|.|:.   .:|::..:....:|.:::.::|      ||..:.....
plant   605 --------QPDSITNSLHSCISDTNQGNSPSKAENIPSCQDLVIEADVS------AIVSVADTSN 655

  Fly   598 EDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDE 662
            ..:||::               |.:||....||.: ..|:    :.|.|.::..::
plant   656 NTEQVSV---------------NPVSPCLSVAPVS-VSPV----LIPPTESASPKI--------- 691

  Fly   663 MFRRSLGQLKT---------DIMRANSLVQEANFLAEEMEKK---------TKFSVTLQIPPANL 709
              |.|...|:|         ||.|||.|..|....:..|..:         ||.|....:|...|
plant   692 --RNSRKSLRTTSMSTASQKDIERANQLTPEVVEPSPAMSTEVLNLYSALSTKKSEAFPVPTRQL 754

  Fly   710 SPNRRRG-----------------------AFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREM 751
            :.:..||                       |...:|:.::.:.:.|.|.:....         |:
plant   755 AASLHRGMKLLDSYRQSTALRRSTFRLSYKALECKPSTVLSKADVGVQTYPQAD---------EI 810

  Fly   752 YQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGR 816
            .:::.:.||....:..|:     .::||   :...:|:.|            .||.:.:|.....
plant   811 AEDNSKEVLCSRCKCRAE-----CDAQE---ISDTSNLQL------------VPIDNSEGSEKSN 855

  Fly   817 LQV--EIERI-AG----QMPQDRMC-ESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPL 873
            .||  .:|:: ||    :|..:..| :..||                                 :
plant   856 FQVPKAVEKVLAGSIRREMAMEEFCTKQASE---------------------------------I 887

  Fly   874 SLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVT----INEEFLEHCIEGAL 934
            |..|.:..||.   |:.....:|.  .|..|:  :.:.|...|..::    ::|||.....|..|
plant   888 SQLNRLVQQYK---HERECNAIIG--QTREDK--IVRLESLMDGVLSKDDFLDEEFASLMHEHKL 945

  Fly   935 SIEVW-GHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGE-YSPVEVTN 997
            ..::: .|.....::.   |:::.|.:..|..:.:.::..:..|..|||:|....: |:...:|:
plant   946 LKDMYENHPEVLQTRI---ELKRVQEELESFKNFYGDMGEREVLLEEIHDLKAQLQCYTDSSLTS 1007

  Fly   998 RNEVLTGGIYQLRQGQQRRVNVRVKPVQ--NSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQE 1060
            ..          |:|...::.....|.|  ...|:|                     ..:|...|
plant  1008 AR----------RRGSLLKLTYACDPNQAPQLNTIP---------------------ESVDEGPE 1041

  Fly  1061 EDLTVLREKWSEA--------------LGRRRQYLDQQIQMLIKKEEKNEQERERELS------- 1104
            :.|...|.:|:||              |...|..:::|     |:|...|:....||:
plant  1042 KTLEQERLRWTEAESNWISLAEELRTELDTNRLLMEKQ-----KRELDTEKRCAEELTEAMQMAM 1101

  Fly  1105 -----LVHQWVSLTEERNAVLV--------------PAPGSGIPGAPASWEPPSGMEPHVPVLFL 1150
                 ::.|:..|.|:...:|.              .|..:|:.||.:.              |:
plant  1102 QGHARMIEQYADLEEKHIQLLARHRRIREGIDDVKKAAARAGVKGAESR--------------FI 1152

  Fly  1151 NLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDS------ 1209
            |....::||.....|..|             :::.       |::    .|..|.:.|:
plant  1153 NALAAEISALKVQREKEV-------------RYFR-------DEN----KSLQSQLRDTAEAVQA 1193

  Fly  1210 --QALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAI 1272
              :.|.|..||.|.:....:..:...:.|          |...||    .|:||:
plant  1194 AGELLVRFKEAEEGLTFAQKRAMDAEYEA----------SEAYKK----VDKLKR---------- 1234

  Fly  1273 WQSGVTYEVVSNIPKASEELEDRESLAQLAAS-GDDC-------SASDGE 1314
                 .||...:........|.:..:..|.|| .||.       |||||:
plant  1235 -----KYETEISTVNQQHNAEPQNPIESLQASCNDDAMAKYDEPSASDGD 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	148/366 (40%)
		KISc	6..359	CDD:214526	148/366 (40%)
		Kinesin_assoc	356..468	CDD:292801	33/146 (23%)
		FHA	446..546	CDD:238017	14/103 (14%)
		KIF1B	741..786	CDD:289208	6/44 (14%)
		DUF3694	<1196..1252	CDD:289256	10/63 (16%)
		CAP_GLY	1786..1850	CDD:279625
KINESIN-12B	NP_189009.2	PLN03188	1..1313	CDD:215621	344/1480 (23%)
		Motor_domain	97..439	CDD:277568	149/367 (41%)
		Kinesin-relat_1	911..997	CDD:289481	17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2548
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910