DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and POK1

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001326049.1	Gene:	POK1 / 820999	AraportID:	AT3G17360	Length:	2075	Species:	Arabidopsis thaliana

Alignment Length:	1961	Identity:	436/1961 - (22%)
Similarity:	725/1961 - (36%)	Gaps:	636/1961 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFN--RREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDE 68
            ::|.:|:||..  .|..:...||: :.|..||::....|..:        |.|||.       ..
plant   169 VQVLIRLRPLGTMERANQGYGKCL-KQESPQTLVWLGHPEAR--------FTFDHV-------AS 217

  Fly    69 NFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG--------TQESKGIIPRLCD 125
            ...|||.:|...|..:::|...|||:|:||||||||||:|||||        ..|..|:..|:.:
plant   218 ETISQEKLFRVAGLPMVENCLSGYNSCVFAYGQTGSGKTYTMMGEISEAEGSLGEDCGVTARIFE 282

  Fly   126 QLFSAI----ANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            .|||.|    ..:....|.:..:.|::|||||::.|||:  |:..:|::||....|.||:.|.:.
plant   283 YLFSRIKMEEEERRDENLKFSCKCSFLEIYNEQITDLLE--PSSTNLQLREDLGKGVYVENLVEH 345

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDL 251
            .|.:..|:..|:.:|..:|.:|||.||:||||||:||:..:..:.  :...::..:.:|::||||
plant   346 NVRTVSDVLKLLLQGATNRKIAATRMNSESSRSHSVFTCTIESLW--EKDSLTRSRFARLNLVDL 408

  Fly   252 AGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDN 316
            |||||...:||.||||||.:||||||:||||||..|.|.::||    .:.||||||.||:||:|:
plant   409 AGSERQKSSGAEGDRLKEAANINKSLSTLGLVIMSLVDLAHGK----HRHVPYRDSRLTFLLQDS 469

  Fly   317 LGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARII---RELRHEVETLR 378
            |||||:|:::|.:|||..:..||||||::|.|||.|.|:|.||||.:..:.   :|:|.....|.
plant   470 LGGNSKTMIIANVSPSLCSTNETLSTLKFAQRAKLIQNNAKVNEDASGDVTALQQEIRKLKVQLT 534

  Fly   379 SMLK-HATGSPVGDVQDKLAES--ENLMKQISQTWEEKL-VKTERIQNERQQALEKMGI---SVQ 436
            |:|| |.:...:.|....|.||  ....|...:|.::|. .:.:.:.:....||.:..|   ::|
plant   535 SLLKNHDSCGALSDCISSLEESRYSGTCKVAGETRQDKCHCQVKNMNDNMIGALRREKIAESALQ 599

  Fly   437 ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIE 501
            .|..::|:....:.::..|....::::...:::  :|       :.:...|| .:..:.|:  ||
plant   600 KSEAEIERIDCLVRDMEEDAKRIKIMLNLREEK--VG-------EMEFCTSG-SLMTKECL--IE 652

  Fly   502 DSGLYMEPVQGARCFVNGS-----AAVEKTPL-----------QNGDRILWGNHHFFRVNSPKSN 550
            ::......::..|..::.:     :|:|.|.|           ::|:|
plant   653 ENKTLKGEIKLLRDSIDKNPELTRSALENTKLREQLQRYQKFYEHGER----------------- 700

  Fly   551 NTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQF 615
             .::.|.......||:|...|:||.....:..:                         .|.|::|
plant   701 -EALLAEVTGLRDQLLDVLEAKDESFSKHVMKE-------------------------NEMEKEF 739

  Fly   616 QQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQ-LKTDIMRAN 679
            :..||:.|                         |.:|      |.||: :..||: |..|.:::|
plant   740 EDCRNMNS-------------------------SLIR------ELDEI-QAGLGRYLNFDQIQSN 772

  Fly   680 SLVQEANFLAEEMEKKTKFSVTLQIP---------PANLSPNRRRGAFVSEPAILVKRTNSGSQI 735
             :|..:...||::.:..|..:...:|         ..:.|.|..|||.|        :|:.|...
plant   773 -VVASSTRGAEQVNQAHKHLMAETMPTISEIQEEVAISHSKNYDRGALV--------KTDEGIDR 828

  Fly   736 WTME-KLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVK 799
            ..:: ||...:.|:.|      .|.||...|.:.|.|   ...||:          :||:...|:
plant   829 SILQFKLGKLMKDLEE------ARTLNCKYEKDHKSQ---LSQQED----------IEVVREQVE 874

  Fly   800 LDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVT 864
            .:....|:..|.||.. ||.|.:|        |:| :::|.:...:|
plant   875 TETARTILELQEEVIA-LQSEFQR--------RIC-NLTEENQSIKD------------------ 911

  Fly   865 IKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHC 929
                                                                 |:|..|.
plant   912 -----------------------------------------------------TITARES----- 918

  Fly   930 IEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVE 994
                                                              ||..||.:.|.:.:|
plant   919 --------------------------------------------------EIRALNQDWEKATLE 933

  Fly   995 VTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTL--PIICQ-SIVNVAIGSVTVRSRLQRPLD 1056
            :|  |.::.|.                |.::|:.|.  .|||. ..||..||
plant   934 LT--NFIVAGS----------------KSIKNASTQIESIICSFPQVNAWIG------------- 967

  Fly  1057 SYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEE-----KNEQERERELSLVHQWVSLTEER 1116
                                  .|:::..:..|||||     :...|..|         .|..|.
plant   968 ----------------------DYVEKAAKNCIKKEETILLLQKSLEDAR---------ILVAEM 1001

  Fly  1117 NAVLVPAPGSGIP-------GAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSI 1174
            |..|....|:.|.       |..|:.|..           .|||.|   ....:||     ::::
plant  1002 NLKLNSLKGATIALNEFQLGGNAATTEEA-----------FNLNND---VDRMSDE-----VDTL 1047

  Fly  1175 LSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDS-QALNRVTEANERVYLILRT-TVRLSHPAP 1237
            .|....:::..|:..:|.:. ...|..|.|...|. |.:.:|.:.:.:.:..|.: :..||....
plant  1048 ESNFKANQYSILKTERHAEA-ALAVTKWLSDSRDQHQMMEKVQDQSVKEFGTLSSISASLSAEGN 1111

  Fly  1238 MDLVLRK--RLS-INIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEV----VSNIPKASEELEDR 1295
            .|:.|.:  .|| ....||..|:.....|     .|..||......|    ||:....::|..::
plant  1112 ADISLSRDGHLSDATYPKGDELSTSSSDF-----SNCRWQHDCALNVKCQGVSSSESDAQESNNK 1171

  Fly  1296 -ESLAQLAASGDDCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLS----- 1354
             .|.|.:|.:|...|...||        |..:||..||:...|:     |.|....:|||
plant  1172 ITSAALIAKNGSAHSVYCGE--------GRQSVEKPLTIMMGRE-----ETEYKCSKPLSSGVYM 1223

  Fly  1355 --MRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHS 1417
              |::...|..|     ||...|  :|....|  |||....|..
plant  1224 GLMQRMDPVRTF-----FDRFEE--VNATMKE--ADLTICELVK--------------------- 1258

  Fly  1418 FGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPED--------------- 1467
                             |:..::.:..|.:.| |||.:...::|.::.|.
plant  1259 -----------------ANEKSNSVTEMWLQT-HEELISKEKNLMDDLEQVKSILSACEEEKQVL 1305

  Fly  1468 ------SYSDSEYAA----EYEQERQQN-----KSMATRSRLTA-------SKTMDSFMDVSSHS 1510
                  :.:|.|.:.    ||.||.::.     :::.:.:||..       |.:..|...::|..
plant  1306 LNQTHTTLADMENSVSLLEEYFQEMKRGVEETVEALFSHARLAGKELLQLISNSRPSLEQIASEF 1370

  Fly  1511 NQSYLSYTSSANANM----------------KHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDI 1559
            .:...:..::...::                .:|:|..|.......:.||.::.......|.|:|
plant  1371 MEREFTMYATYQCHIGKLIDQILDQRKQVITPNLSGQETNQSVKINAIGYNAEDEVTKKQSREEI 1435

  Fly  1560 AS-------------------------MRSMSIDETPDFD-RVNSNSPPNRQARVNPFLKDMPK- 1597
            .:                         .|..::.|...|| |:...|..|::...|    :|.:
plant  1436 VTGLENDEVVQSHESLLYENLYLKKELERKEALFEGLLFDFRLLQESASNKRDIKN----EMDEL 1496

  Fly  1598 ----AKIQEQPEQQAKKLQEAFTHPLEQLESSQ--------NAQSDDDECAQ----LPKNNNNNL 1646
                .|:|.:.|.:|.::.|.|.|. |.||:..        .:|||.::..|    |.:.|:...
plant  1497 FDALCKVQLELELKASQVHELFVHN-ENLENCSIDLKTALFTSQSDLEQAKQRIQILAEQNDELR 1560

  Fly  1647 DLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNG--NRSSDELSH----SSEDLLEGDGIVREE 1705
            .||::             :.:.|:..|...|.|..  ||...|:.|    :.:.||.....::|.
plant  1561 ALVSD-------------LCKEKAAAEEGLDEQRDLVNRLEKEILHLTTTAEKQLLSAVKSIKEN 1612

  Fly  1706 LPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDE 1770
            |        ||::.:.....:.|.:.||....|..|........:|.......|.|.....|  |
plant  1613 L--------KKTSDEKDQIVDEICSLNNKLELAYAIADEKEAIAVEAHQESEASKIYAEQKE--E 1667

  Fly  1771 ESKDVELVLPE 1781
            |.|.:|:.:.|
plant  1668 EVKILEISVEE 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	151/366 (41%)
		KISc	6..359	CDD:214526	151/366 (41%)
		Kinesin_assoc	356..468	CDD:292801	26/121 (21%)
		FHA	446..546	CDD:238017	14/115 (12%)
		KIF1B	741..786	CDD:289208	11/44 (25%)
		DUF3694	<1196..1252	CDD:289256	13/60 (22%)
		CAP_GLY	1786..1850	CDD:279625
POK1	NP_001326049.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2548
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910