DRSC/TRiP Functional Genomics Resources

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Protein Alignment Khc-73 and KIF18A

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:NP_112494.3 Gene:KIF18A / 81930 HGNCID:29441 Length:898 Species:Homo sapiens


Alignment Length:862 Identity:253/862 - (29%)
Similarity:378/862 - (43%) Gaps:165/862 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLE------------KIERKQPK--TFAF 56
            :||.|||||.|.:|.......:|.:..:..::.:|...|            .:.:||.|  .|.|
Human    12 MKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVF 76

  Fly    57 DHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
            |..|      ||. ::|..||:...:.||.:...|||..:.|||.||:||::||:|:.:..|::.
Human    77 DAVF------DET-STQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMY 134

  Fly   122 RLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            .....|:..: ::...|.:....|||:|:|||::.|||   .|...|.|||....|..|.||:..
Human   135 LTMLHLYKCM-DEIKEEKICSTAVSYLEVYNEQIRDLL---VNSGPLAVREDTQKGVVVHGLTLH 195

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVS-GEKVSRMSLVD 250
            ...|.::|.:|:..|||:||...|:|||.||||||||.:.|.|  .|:...:: ..::::|||:|
Human   196 QPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQ--QDKTASINQNVRIAKMSLID 258

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            |||||||..:||.|.|..||:|||:||..||.||:.|||...     .::.:|||:|.||.||||
Human   259 LAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR-----KNQHIPYRNSKLTRLLKD 318

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI----------VNHAVVNEDPNARIIREL 370
            :||||.:|:|:|.:|||:..|::|.:||:||:|||.|          ||:.:..   ..:|..|.
Human   319 SLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQ---YVKICNEQ 380

  Fly   371 RHEVETLRSMLK----HATGSPVGDVQDKLAESENLMKQISQTWE-------------------E 412
            :.|:..|:..||    ....:...| |.||..|....|:|.:..|                   |
Human   381 KAEILLLKEKLKAYEEQKAFTNEND-QAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLE 444

  Fly   413 KLVKTERIQNERQQALEKMGISVQASGIKVE----KNKYYLVNLNADPSLNELLVYYLKDRTLIG 473
            .|:|...:::..||...|. |.:..|..|||    |..:.|..|....|       ||:.|    
Human   445 MLLKENELKSFYQQQCHKQ-IEMMCSEDKVEKATGKRDHRLAMLKTRRS-------YLEKR---- 497

  Fly   474 GRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVE-KTPLQNGDRILWG 537
             |....:|.|...:.|     |.|  .::.||..:         ||....| |..|.        
Human   498 -REEELKQFDENTNWL-----HRV--EKEMGLLSQ---------NGHIPKELKKDLH-------- 537

  Fly   538 NHHFFRVNSP-KSNNTSM----CASEP---QTPAQL------IDYNFARDEIMQNELSNDPIQTA 588
            .||....|.. |:....|    |..|.   ||.|.|      :...:.  .:.:..|||...::.
Human   538 CHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYC--TLKEAGLSNAAFESD 600

  Fly   589 IARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRV 653
            ...:|...|..|.|....|..|..:| ..|..| |....:....|..|:.....:..|...::..
Human   601 FKEIEHLVERKKVVVWADQTAEQPKQ-NDLPGI-SVLMTFPQLGPVQPIPCCSSSGGTNLVKIPT 663

  Fly   654 EKWAQERDEMFRRSL-GQ--LKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRR 715
            ||  :.|.::....| ||  ||:.   .:..||..:.|::|::            |...:|...|
Human   664 EK--RTRRKLMPSPLKGQHTLKSP---PSQSVQLNDSLSKELQ------------PIVYTPEDCR 711

  Fly   716 GAFVSEPAILVKR----TNSGSQIWTMEKLENKLIDMREMYQEHKERVLNG---LD------ED- 766
            .||.:...:.:.:    |.|...|.:....:|.|..:.|:...|..|...|   ||      || 
Human   712 KAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDI 776

  Fly   767 -NAKPQDPFYESQENHN 782
             ::|.:.|..||..|.|
Human   777 KSSKCKLPEQESLPNDN 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 145/377 (38%)
KISc 6..359 CDD:214526 145/377 (38%)
Kinesin_assoc 356..468 CDD:292801 31/138 (22%)
FHA 446..546 CDD:238017 21/100 (21%)
KIF1B 741..786 CDD:289208 16/53 (30%)
DUF3694 <1196..1252 CDD:289256
CAP_GLY 1786..1850 CDD:279625
KIF18ANP_112494.3 KISc_KIP3_like 11..355 CDD:276821 142/360 (39%)
Kinesin 17..355 CDD:278646 139/355 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..690 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..871
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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