DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and CLIP4

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001274456.1	Gene:	CLIP4 / 79745	HGNCID:	26108	Length:	705	Species:	Homo sapiens

Alignment Length:	409	Identity:	101/409 - (24%)
Similarity:	168/409 - (41%)	Gaps:	118/409 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1524 NMKHLTGLATLSMSSSTSSG--YGSQAVSCNNLSNEDIASMR-------------SMSIDETPDF 1573
            |..|:||.|.|     ||.|  .|.:.|    ::.:.:.::|             .:.:||.
Human   268 NYDHVTGKAML-----TSLGLKLGDRVV----IAGQKVGTLRFCGTTEFASGQWAGIELDEP--- 320

  Fly  1574 DRVNSNSPPNRQARVNPFLKDMPK-------AKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSD 1631
            :..|:.|....|     :.|..||       :||     .:||..::..||......:....:|.
Human   321 EGKNNGSVGKVQ-----YFKCAPKYGIFAPLSKI-----SKAKGRRKNITHTPSTKAAVPLIRSQ 375

  Fly  1632 DDECAQLPKNNNNNLDLVNEPKPLSSQTD--LEESMSQPKSKTEFATDNQN-----GNRSSDELS 1689
            ..:.|.:....|..|        ::|:.|  .|.::|.|..: |..|..:.     |:.||...:
Human   376 KIDVAHVTSKVNTGL--------MTSKKDSASESTLSLPPGE-ELKTVTEKDVALLGSVSSCSST 431

  Fly  1690 HSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLA 1754
            .|.|.        |:..|       ||.        |:|::|....:::|.::.|||
Human   432 SSLEH--------RQSYP-------KKQ--------NAISSNKKTMSKSPSLSSRAS-------- 465

  Fly  1755 AYLDSSIMTSSTEVDEESK-DVELVLPEWI-VVGESVLIRPYNTSGVIRFVGTTEFQPGAWIGVE 1817
                :.:.:|:|.....|: :.||.|.|.: |||:.:        |.|||.|||.|.||.|.|:|
Human   466 ----AGLNSSATSTANNSRCEGELRLGERVLVVGQRL--------GTIRFFGTTNFAPGYWYGIE 518

  Fly  1818 LDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLM-----LD--------KRGKAMRAYKAAEKSN 1869
            |:.|.|||||||.|||||.|.|::|:|....::.     ||        |:..:...::.:..:.
Human   519 LEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTT 583

  Fly  1870 SISKEMSTSMTGSMTRSKS 1888
            |.|.:...:...:.::||:
Human   584 SASSQKEINRRNAFSKSKA 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816
		KISc	6..359	CDD:214526
		Kinesin_assoc	356..468	CDD:292801
		FHA	446..546	CDD:238017
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625	32/63 (51%)
CLIP4	NP_001274456.1	ANK 1	65..101
		ANK	98..252	CDD:238125
		ANK repeat	109..146	CDD:293786
		ANK 2	149..180
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK 3	186..215
		CAP_GLY	285..349	CDD:307465	11/75 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..479		15/82 (18%)
		CAP_GLY	487..551	CDD:307465	36/71 (51%)
		CAP_GLY	626..690	CDD:307465
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900