DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Stard9

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_017447698.1	Gene:	Stard9 / 691920	RGDID:	1593360	Length:	4604	Species:	Rattus norvegicus

Alignment Length:	1996	Identity:	497/1996 - (24%)
Similarity:	774/1996 - (38%)	Gaps:	561/1996 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE-----RKQPKTFAFDHCFYSLNP 65
            ::|||||||.::||.:...:.|||::.:...::|.....::|     |::...|.||:|::|:||
  Rat     4 VQVAVRVRPLSKRETKEGGRIIVEVDDKVAKVRNVKVNSRLESFGDTREKVVAFGFDYCYWSVNP 68

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSA 130
            ||.::||||.||..:|..:|..|.:|||.|:||||||||||:|||:||..|.|:.||:|:.||
  Rat    69 EDPHYASQEVVFRDLGTEVLSGASKGYNICLFAYGQTGSGKTYTMLGTPASVGLTPRICEGLF-- 131

  Fly   131 IANKSTPELMY--KVEVSYMEIYNEKVHDLLDPKPNKQS--LKVREHNVMGPYVDGLSQLAVTSY 191
            |.......:.|  .::||::|||||:|.|||......:|  |:||||..|||||.||||.|||||
  Rat   132 IREDDCASMPYSRSIKVSFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHAVTSY 196

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSER 256
            |.:..|:.||..:|..|||:::..||||||:|::..||....  ..:..|..|:::|||||||||
  Rat   197 QQVLQLLEEGIANRITAATHVHEASSRSHAIFTIHCTQATLQ--NNLPSETASKINLVDLAGSER 259

  Fly   257 AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQS-------------------------NGKKS 296
            | ......||:.||:||||||.|||:|||.||..|                         :|..|
  Rat   260 A-DPSYCKDRITEGANINKSLVTLGIVISTLAQNSQVFSSCQSLSSAASSGGDSGIPSTTSGTSS 323

  Fly   297 G-----NDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHA 356
            |     ...::||||||||||||::|||||:|:||||:||:..:|.||:||:|||..||.|:|..
  Rat   324 GGGPARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNAKNIINKP 388

  Fly   357 VVNEDPNARIIRELRHEVETLRSMLKHATGSPVGDVQDKLAES------ENLMK--QISQTWEEK 413
            .||||.|.::|||||.|:|.|::||.:........:.|.|.||      :|.:|  .::|.|.:|
  Rat   389 QVNEDANVKLIRELREEIERLKAMLLNFELRNFSSLNDDLDESLQELVFQNDLKIDTLTQHWTQK 453

  Fly   414 LVKTERIQNERQQALEKMGISVQASGIKV--EKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRT 476
                   .|.||..:|..|:.:..:..:|  :.:..:|:.|..|.....:::|:||:.|...||.
  Rat   454 -------PNNRQALMEHYGVGINRNRARVVIDSSLPHLMALEDDVLSTGIVLYHLKEGTTRIGRI 511

  Fly   477 ISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHF 541
            .|.|:.||.|.|..|:.:||.||.....:.:.|.|||||.|||........|..|..|..|....
  Rat   512 DSDQEQDIVLQGQWIERDHCTITSTCGVVILRPSQGARCTVNGREVTASCRLTQGAVITLGKAQK 576

  Fly   542 FRVNSPKS----NNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIAR-LERQHEEDKQ 601
            ||.|.|..    ....:...|....:..:::.....::..:.|...|:.....| ||.|.::|:|
  Rat   577 FRFNHPAEAAALRQERLKVGEVLGSSGSLEWLDLDGDVSASRLGLCPVLRKERRVLEEQSDKDQQ 641

  Fly   602 VALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMR--VEKWAQERDEMF 664
                                              |||.|||:....|.|.:  ||...|:..|..
  Rat   642 ----------------------------------PLRNGKISYRAQTEQQQCHVEALKQQAKEGQ 672

  Fly   665 RRSLGQLKTDIMRANS--------LVQEANFLA------------EEMEKKTKFS------VTLQ 703
            .|...:||.|....|.        |::|..:|:            ||.|.:...:      ...|
  Rat   673 SRVQKELKLDQTHINRKITDNQQWLLREETWLSNLRETQQEGDCGEEKELEAFVAPDAWLPTVPQ 737

  Fly   704 IPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTME------KLENKLIDMREMYQEHKERVLNG 762
            .||:.|..:::|   |.:|..|.|.| |.:.:|.:.      :||..:...|.:..:.:...||.
  Rat   738 TPPSPLVQSQKR---VVQPRCLRKHT-SRATVWNIRQKKVSFQLERIIKKRRLLEAQRRLEQLNA 798

  Fly   763 L--DEDNAKPQDPFYESQENHNLIG---------VANIFLEVLFHDVKLDYHTPIISQQGEVAGR 816
            |  .:||...:.|.:.|..|....|         .:::.|:.|.........:.:::..   ...
  Rat   799 LFWIQDNGTSKAPSWASSSNTTGSGSQRRSRWTTCSSLSLQRLCSQRLSQLRSAVMNWD---PSA 860

  Fly   817 LQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFC 881
            :...:..:..|||:..:                 ..|.......|.....|.....|..|.
  Rat   861 MSPPVPDLTQQMPEKTL-----------------STDTVPQATACPPRTGCLGRNSLHSSR---- 904

  Fly   882 QYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGF 946
                |.                      ||...:..:|:            :..||.:|.:|...
  Rat   905 ----WR----------------------KFSPARGASVS------------SQKIESFGKQSCQM 931

  Fly   947 SKTKGWEVEQQ-------------QAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNR 998
            | ::|...::|             |.||:.||   |.::.: .:|.:  |.:.....:|.|.|:.
  Rat   932 S-SQGQSTKKQKPTDGSRIFTPAAQTKAKGLV---ASVNTQ-TVWQK--EESCATYKAPKETTSH 989

  Fly   999 NEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIIC----QSIVNVAIGSVTVR-SRLQ--RPLD 1056
            ...|:|.    .|....|..|:....::....|...    |.::......:..: |||.  .||.
  Rat   990 PTYLSGS----EQVAGHRKVVKTSLAESKPPPPSRASKKHQRVLAARARDIAKKFSRLSCGCPLK 1050

  Fly  1057 SY-QEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQEREREL---SLVHQWVSLTEERN 1117
            .. ..||.|...:.        |..:|.     :::|:|:..:.|...   ||.:.:..:.:|
  Rat  1051 KQPSAEDPTSFTDS--------RPIMDH-----VREEDKDLSDTESSYSVDSLSYIYAKVPKE-- 1100

  Fly  1118 AVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSI-------- 1174
             :|.|....|      .|:.|   :|.        |.:..::|.:.|.|:..|..|:
  Rat  1101 -LLKPEELQG------KWDLP---DPD--------NSESGNSQISEDSLAGKGHQSLPENSAGEY 1147

  Fly  1175 LSKEHGHK------------FYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILR 1227
            ..|::||.            .|:       |..:|.......|:|     :.:...|.:....|.
  Rat  1148 SMKDYGHSRARPSASVRGLPMYS-------DSSLCTHTDRSFSLH-----SLIGPENRQGEPFLG 1200

  Fly  1228 TTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEV---VSNI-PKA 1288
            :...:  |......|:|.....|...|..|||              .|.:.:.|   |:|| ||:
  Rat  1201 SADEM--PTETFWHLQKATLSAIDNRQGATDR--------------PSPINHRVGVRVNNILPKS 1249

  Fly  1289 SEELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPL 1353
            :....|.:                       |......:||              |:||::.:.:
  Rat  1250 NSFYHDLQ-----------------------YQPRCEQLES--------------EMETSYSEQI 1277

  Fly  1354 SMRKTVSVPNFSQIMRFDA--SMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRH 1416
            :..:.:.:...|.::..|:  |.:|.:|                         |:...|||.|..
  Rat  1278 NPLRGIQLARESPLLSVDSWFSCDSKVN-------------------------PSSPSGVIHSLC 1317

  Fly  1417 SFGGKGSSD--------DSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSE 1473
            .     |.|        :.|........|.|.||    ..|..|.|..         .|.|:.|
  Rat  1318 P-----SPDIHETQPYSEKPQHWLSSEEPNTCKL----PQTSTEPPCS---------SDLYATS- 1363

  Fly  1474 YAAEYEQERQQNKSMATRSRLTASKTMDSFM---DVSSHSNQSYLSYTSSANANMKHLTGLATLS 1535
                   ....:|.....|:......:|.|.   ::...:||                 |::..|
  Rat  1364 -------ASDTSKPSVCGSQRLLQPGVDGFFQGREMPDMTNQ-----------------GISEES 1404

  Fly  1536 MSSSTSSGYGSQAVS---CNNLSNEDIASMRSMSIDETPD--FDRVNSNSPPNRQARVNPFLKDM 1595
            .:|..||...:.|.|   ..:::.:|.|::....:.|..|  |:.:....|      ..|||::
  Rat  1405 HNSDMSSVLATSATSFTHVRSINKKDWAALHQEYLLELSDSIFEAIGEPRP------AFPFLEE- 1462

  Fly  1596 PKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNN--NNNLDLVNEPKPLSSQ 1658
                                       |||..|.:.|...:.||...  :.|||..:.|..||..
  Rat  1463 ---------------------------ESSSLADASDKVDSPLPTGPGLSRNLDFCSFPAHLSQI 1500

  Fly  1659 TDLEESMSQPKSKTEFATDNQNGNRSSDELS---HSSEDLL---------EGDGIVREELPAGKV 1711
            ..|                  |..:..|.||   .|:.||.         |......|.|.:|.:
  Rat  1501 RHL------------------NAEKDHDSLSANVESASDLFSTVERMSCNEAYPTDIESLTSGSI 1547

  Fly  1712 VRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEG-LAAYLDSSIMTSSTEV------- 1768
                  |.|..:.||:|.::   .|:|..:|.    |.:|| |.....|::.|||.:.
  Rat  1548 ------NAQACTAGNAIPSS---MTEAWEVNQ----ASLEGCLQGGRHSALKTSSGQYFFQKRTY 1599

  Fly  1769 ---DEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQPG 1811
               |..:.:|: .||:     :..|:|.           .|..|||
  Rat  1600 HNHDTSASEVD-YLPQ-----DETLLRK-----------NTPVQPG 1628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	179/391 (46%)
		KISc	6..359	CDD:214526	179/391 (46%)
		Kinesin_assoc	356..468	CDD:292801	35/121 (29%)
		FHA	446..546	CDD:238017	35/99 (35%)
		KIF1B	741..786	CDD:289208	12/55 (22%)
		DUF3694	<1196..1252	CDD:289256	9/55 (16%)
		CAP_GLY	1786..1850	CDD:279625	6/26 (23%)
Stard9	XP_017447698.1	KISc_KIF1A_KIF1B	2..391	CDD:276816	179/391 (46%)
		KISc	3..391	CDD:214526	179/391 (46%)
		Kinesin_assoc	390..504	CDD:292801	36/120 (30%)
		FHA	481..581	CDD:238017	35/99 (35%)
		CBP4	<4150..4247	CDD:285235
		SRPBCC	4378..4552	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920