DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KIF13A

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_071396.4	Gene:	KIF13A / 63971	HGNCID:	14566	Length:	1805	Species:	Homo sapiens

Alignment Length:	1906	Identity:	929/1906 - (48%)
Similarity:	1199/1906 - (62%)	Gaps:	226/1906 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKI-ERKQPKTFAFDHCFYSLN 64
            |:..|:||||||||.||||:||:|||:||||..||:|..||...|. |||.||.||||:||:|::
Human     1 MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMD 65

  Fly    65 PED-ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLF 128
            ..: ..:|.||.||.|:|.|||:.||||||||||||||||||||::|||..|..|:|||||..||
Human    66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALF 130

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            ..|:.:......:||||||||||||||.||||||.::||||||||.|:||||||||||||||::|
Human   131 KRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFED 195

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAV 258
            |::||:||||||||||||||.|||||||||::::||.|.|..:|.||||||::||||||||||..
Human   196 IESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVS 260

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            ||||.|:||||||||||||||||||||.||||:.||  |..||||||||||||||||||||||:|
Human   261 KTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGK--GKSKFVPYRDSVLTWLLKDNLGGNSQT 323

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSP 388
            .|:|||||:||||||||||||||||||||||||||||||||::|||||.|||.||..|..|....
Human   324 SMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMK 388

  Fly   389 VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLN 453
            ..::::||.|||.|:|:::.||||||.|||.|..|||:.||.||||::.|||||..:|.||||||
Human   389 APELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIKVGDDKCYLVNLN 453

  Fly   454 ADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITI-EDSGLYMEPVQGARCFV 517
            |||:|||||||||||.|.:|..|    ..||||.|:||||:||.|.| .|..:.:.|.:.||..|
Human   454 ADPALNELLVYYLKDHTRVGADT----SQDIQLFGIGIQPQHCEIDIASDGDVTLTPKENARSCV 514

  Fly   518 NGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNN--------------------TSMCASEPQTP 562
            ||:.....|.|.:||||||||:||||:|.||...                    .|..:|||
Human   515 NGTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDWLKDFEKETGPPEHDLDAASEASSEP--- 576

  Fly   563 AQLIDYN--FARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSP 624
                |||  ||:.|::...| ||||:|..:..||:|:.|:|:.|||:||..|||:.:|||..|||
Human   577 ----DYNYEFAQMEVIMKTLNSNDPVQNVVQVLEKQYLEEKRSALEEQRLMYERELEQLRQQLSP 637

  Fly   625 STPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLA 689
            ........|      .::..::.|:|.:|.:||:||||:||:||.:|:..:::||:||:||||||
Human   638 DRQPQSSGP------DRLAYSSQTAQQKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLA 696

  Fly   690 EEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQE 754
            |||.|.|.:.||||||.||||.||:|||.||||||.|:|....:|:||:|||||||||||::|||
Human   697 EEMSKLTDYQVTLQIPAANLSANRKRGAIVSEPAIQVRRKGKSTQVWTIEKLENKLIDMRDLYQE 761

  Fly   755 HKERV-----LNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVA 814
            .||:|     |.|      |..|||||:|||||||||||:|||.||.||||.|..||||||||||
Human   762 WKEKVPEAKRLYG------KRGDPFYEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVA 820

  Fly   815 GRLQVEIERIAGQMP----QDRMCESVSESSG----DSRDEYDDPVDPTSNQITCRVTIKCASGL 871
            |||.||:.|:.|.:|    :|...|:.|||..    ||..|....|    .::||||.||.|:||
Human   821 GRLHVEVMRVTGAVPERVVEDDSSENSSESGSLEVVDSSGEIIHRV----KKLTCRVKIKEATGL 881

  Fly   872 PLSLSNFVFCQYTFWGHQEMVV--PVINAE---STAHDQNMVFKFEHTQDFTVTINEEFLEHCIE 931
            ||:||||||||||||...|..|  ||::.|   ..:.|......|.|.:|:.|.:.|||||...:
Human   882 PLNLSNFVFCQYTFWDQCESTVAAPVVDPEVPSPQSKDAQYTVTFSHCKDYVVNVTEEFLEFISD 946

  Fly   932 GALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVT 996
            |||:|||||||.|| :.:..|||:...||.|:|.|||.|::|:||:|:.|.|||:.|||:.||:.
Human   947 GALAIEVWGHRCAG-NGSSIWEVDSLHAKTRTLHDRWNEVTRRIEMWISILELNELGEYAAVELH 1010

  Fly   997 NRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRS-RLQRPL----- 1055
            ...:|.||||:|||||..|||.|.|||||:|||||::.::|::|:||.||.|| :|||.|
Human  1011 QAKDVNTGGIFQLRQGHSRRVQVTVKPVQHSGTLPLMVEAILSVSIGCVTARSTKLQRGLDSYQR 1075

  Fly  1056 --------DSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSL 1112
                    ||||||||..:||:||:||.:||:|||:||:.:..|.||.|.:.|||..||.|||.|
Human  1076 DDEDGDDMDSYQEEDLNCVRERWSDALIKRREYLDEQIKKVSNKTEKTEDDVEREAQLVEQWVGL 1140

  Fly  1113 TEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDEL---SVAGINSI 1174
            |||||||||||||||||||||.|.||.|||.|:|||||:||.|||||   |::|   ..:|:|||
Human  1141 TEERNAVLVPAPGSGIPGAPADWIPPPGMETHIPVLFLDLNADDLSA---NEQLVGPHASGVNSI 1202

  Fly  1175 LSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMD 1239
            |.||||.:|:.|.|::|.|.:|...||||||:|||..|||||..|||:|||::|||:|||||.|:
Human  1203 LPKEHGSQFFYLPIIKHSDDEVSATASWDSSVHDSVHLNRVTPQNERIYLIVKTTVQLSHPAAME 1267

  Fly  1240 LVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAAS 1304
            ||||||::.||...|:.|..||  |.:..:|..:..|||||:|||||||:||:||||:||.|||.
Human  1268 LVLRKRIAANIYNKQSFTQSLK--RRISLKNIFYSCGVTYEIVSNIPKATEEIEDRETLALLAAR 1330

  Fly  1305 GDDCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQI-- 1367
            .::...||||||||||||||..||:||:|:||||.|.|||..:...:  .:|:::|.||...:
Human  1331 SENEGTSDGETYIEKYTRGVLQVENILSLERLRQAVTVKEALSTKAR--HIRRSLSTPNVHNVSS 1393

  Fly  1368 MRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD------ 1426
            .|.|.|.....:.|..|:..|:::      ::.:....|..|.:.|.......:|.:.:
Human  1394 SRPDLSGFDEDDKGWPENQLDMSD------YSSSYQDVACYGTLPRDSPRRNKEGCTSETPHALT 1452

  Fly  1427 -SPGKAFGIASPATSKLL------GMRMTTLHEEPLGGHRSLDEEPEDSYS-------------- 1470
             ||.|||....|...|.|      ..:...|...||....|:  .|..:::
Human  1453 VSPFKAFSPQPPKFFKPLMPVKEEHKKRIALEARPLLSQESM--PPPQAHNPGCIVPSGSNGSSM 1515

  Fly  1471 ----DSEYAAEYEQERQQNKSMATRSRLTASK--TMDSFMDVS----SHSNQSYLSY---TSSAN 1522
                :|:...:.:.|.::|:..|...:|.:|:  ....|.|.|    |..|:.:.|.   .|::.
Human  1516 PVEHNSKREKKIDSEEEENELEAINRKLISSQPYVPVEFADFSVYNASLENREWFSSKVDLSNSR 1580

  Fly  1523 ANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRS---MSIDETPDFDRVNSNSP--- 1581
            ...|.::...|   :||.:|||.|.:.|...||:..:.|..|   ::| :|.|.|....::|
Human  1581 VLEKEVSRSPT---TSSITSGYFSHSASNATLSDMVVPSSDSSDQLAI-QTKDADSTEHSTPSLV 1641

  Fly  1582 ----PNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNN 1642
                |:....:....|.:.|.||...|.::...|          .:.|.::||       :|:.|
Human  1642 HDFRPSSNKELTEVEKGLVKDKIIVVPLKENSAL----------AKGSPSSQS-------IPEKN 1689

  Fly  1643 NNNLDLVNEPKPLSSQTDLEESMSQ------PKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGI 1701
            :.:|........|.:   ....:||      |:..|...|.|...:.|..|....||. .:.||:
Human  1690 SKSLCRTGSCSELDA---CPSKISQPARGFCPREVTVEHTTNILEDHSFTEFMGVSEG-KDFDGL 1750

  Fly  1702 VREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSST 1766
            .  :..||::..|:           |:.|...|.|.:..::|               .|.:.|..
Human  1751 T--DSSAGELSSRR-----------SLPNKTGGKTVSDGLHH---------------PSQLHSKL 1787

  Fly  1767 EVDEESKDVELVLPE---WIV 1784
            |.|      ::::||   |::
Human  1788 END------QVIIPEAAFWVL 1802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	260/356 (73%)
		KISc	6..359	CDD:214526	259/354 (73%)
		Kinesin_assoc	356..468	CDD:292801	71/111 (64%)
		FHA	446..546	CDD:238017	58/100 (58%)
		KIF1B	741..786	CDD:289208	30/49 (61%)
		DUF3694	<1196..1252	CDD:289256	38/55 (69%)
		CAP_GLY	1786..1850	CDD:279625
KIF13A	NP_071396.4	KISc_KIF1A_KIF1B	5..359	CDD:276816	260/355 (73%)
		Kinesin_assoc	356..468	CDD:318424	71/111 (64%)
		FHA	446..543	CDD:238017	58/100 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575		1/18 (6%)
		SMC_N	<606..771	CDD:330553	91/170 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..656		4/28 (14%)
		KIF1B	748..792	CDD:315155	30/49 (61%)
		DUF3694	<1215..1279	CDD:315198	40/63 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1385..1404		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1507..1531		1/23 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1612..1645		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1749..1779		8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	490	1.000	Domainoid score	I377
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1534	1.000	Inparanoid score	I96
Isobase	1	0.950	-	0	Normalized mean entropy	S2420
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		otm42243
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820