DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Khc-73 and STARD9

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:XP_011520133.1 Gene:STARD9 / 57519 HGNCID:19162 Length:4705 Species:Homo sapiens


Alignment Length:2105 Identity:513/2105 - (24%)
Similarity:807/2105 - (38%) Gaps:599/2105 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE---------RKQPKTFAFDHCFY 61
            ::|||||||.::||.:...:.|||::.:...::|    .|::         |::...|.||:|::
Human     4 VQVAVRVRPLSKRETKEGGRIIVEVDGKVAKIRN----LKVDNRPDGFGDSREKVMAFGFDYCYW 64

  Fly    62 SLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQ 126
            |:||||..:|||:.||..:|..:|....:|||.|:||||||||||:|||:||..|.|:.||:|:.
Human    65 SVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPASVGLTPRICEG 129

  Fly   127 LFSAIANKSTPEL--MYKVEVSYMEIYNEKVHDLLDPKPNKQS--LKVREHNVMGPYVDGLSQLA 187
            ||  :..|....|  ..:::||::|||||:|.|||.....|:|  |:||||..|||||.||||..
Human   130 LF--VREKDCASLPSSCRIKVSFLEIYNERVRDLLKQSGQKKSYTLRVREHPEMGPYVQGLSQHV 192

  Fly   188 VTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLA 252
            ||:|:.:..|:.||..:|..|||:::..||||||:|::..||.:.:  ..:..|..|:::|||||
Human   193 VTNYKQVIQLLEEGIANRITAATHVHEASSRSHAIFTIHYTQAILE--NNLPSEMASKINLVDLA 255

  Fly   253 GSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQ--------------SNGKKSG------ 297
            ||||| ......||:.||:||||||.|||:|||.||..              |||..||      
Human   256 GSERA-DPSYCKDRIAEGANINKSLVTLGIVISTLAQNSQVFSSCQSLNSSVSNGGDSGILSSPS 319

  Fly   298 ----------NDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI 352
                      ...::|||||||||||||:|||||:|:||||:||:..:|.||:||||||..||.|
Human   320 GTSSGGAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSAKNI 384

  Fly   353 VNHAVVNEDPNARIIRELRHEVETLRSM-----LKHATGSPVGDVQDKLAESENLMKQISQTWEE 412
            :|...||||.|.::|||||.|:|.|:::     |::.:.....::::.:.::|..:.|:::.|.:
Human   385 INKPRVNEDANLKLIRELREEIERLKALLLSFELRNFSSLSDENLKELVLQNELKIDQLTKDWTQ 449

  Fly   413 KLVKTERIQNERQQALEKMGISV--QASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGR 475
            |       .|:.|..:|...:.:  :.:|:.::.:..:|:.|..|.....:::|:||:.|...||
Human   450 K-------WNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLKEGTTKIGR 507

  Fly   476 TISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHH 540
            ..|.|:.||.|.|..|:.:||.||.....:.:.|.:||||.|||........|..|..|..|...
Human   508 IDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCRLTQGAVITLGKAQ 572

  Fly   541 FFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIA----------RLERQ 595
            .||.|.|..      |:..:...|:.:....|..:...:|..|...:.:.          .||.|
Human   573 KFRFNHPAE------AAVLRQRRQVGEAAAGRGSLEWLDLDGDLAASRLGLSPLLWKERRALEEQ 631

  Fly   596 HEEDKQVALE------KQRQEYERQFQQLRN-ILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRV 653
            .:||.|...:      .|.|:.:...:.||: ||:.....|....:|...:.:.........:|.
Human   632 CDEDHQTPRDGETSHRAQIQQQQSYVEDLRHQILAEEIRAAKELEFDQAWISQQIKENQQCLLRE 696

  Fly   654 EKW------AQERDEMFRRSL-------GQLKTD-------------------IMRANSL----- 681
            |.|      .|:.|::..:.|       ..|:||                   ::|.::|     
Human   697 ETWLASLQQQQQEDQVAEKELEASVALDAWLQTDPEIQPSPFVQSQKRVVHLQLLRRHTLRAAER 761

  Fly   682 ---VQEANFLAE---------EMEKKTKFSVTL--------QIPPAN-LSPNRRRGAFVSEPAIL 725
               .::.:|..|         |.:|:.:...||        |.||.. |||:    |.|..|...
Human   762 NVRRKKVSFQLERIIKKQRLLEAQKRLEKLTTLCWLQDDSTQEPPYQVLSPD----ATVPRPPCR 822

  Fly   726 VKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKP--QDPFYESQENHNLIGVAN 788
            .|.|:..|       |..:.:..:.|.|.|.  :....|.....|  .||.:::.|.        
Human   823 SKLTSCSS-------LSPQRLCSKHMPQLHS--IFLSWDPSTTLPPRPDPTHQTSEK-------- 870

  Fly   789 IFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVD 853
                     ...:.|.|..:......|.|:                ::...|||..:        
Human   871 ---------TSSEEHLPQAASYPARTGCLR----------------KNGLHSSGHGQ-------- 902

  Fly   854 PTSNQITCRVTI---------KCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAE--------ST 901
                ..|.|..:         .|.:..|.|:           |.|||.:.|....        |.
Human   903 ----PCTARAALARKGASAPDACLTMSPNSV-----------GIQEMEMGVKQPHQMVSQGLASL 952

  Fly   902 AHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVD 966
            ....|.:......:.||.|..       ..||..:....|..||:.| :|.....:.||..|...
Human   953 RKSANKLKPRHEPKIFTSTTQ-------TRGAKGLADPSHTQAGWRK-EGNLGTHKAAKGASCNS 1009

  Fly   967 RWAELSRKI--------ELWVEIHELNDNGEY---SPVEVTNRNEVLTGGIYQLRQGQQRRVNVR 1020
            .:....|:.        ..|.         ||   ||...:.|:              ||.:..|
Human  1010 LYPHGPRQTAGHGKAVKTFWT---------EYKPPSPSRASKRH--------------QRVLATR 1051

  Fly  1021 VKPV-QNSGTLPIICQSIVNVAIGSVTVRSRLQR------PLDSY---------QEEDLTVLREK 1069
            |:.: :.|..||          :||...|.:..|      ||..:         ::.||:.....
Human  1052 VRNITKKSSHLP----------LGSPLKRQQNTRDPDTMVPLTDFSPVMDHSREKDNDLSDTDSN 1106

  Fly  1070 WS-EALGRRRQYLDQQIQMLIKKEEK-------NEQERERELSLVHQWVSLTEERNAVLVPAPGS 1126
            :| ::|.  ..|....|:.|..:|.|       |.:..:.:||    ..||.|:|    ..:|.:
Human  1107 YSLDSLS--CVYAKALIEPLKPEERKWDFPEPENSESDDSQLS----EDSLAEKR----YQSPKN 1161

  Fly  1127 GIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKE---HGHKFYTLQI 1188
            .:.|                    |...::.....|....||.|..:....:   ..|:.::|..
Human  1162 RLGG--------------------NRPTNNRGQPRTRTRASVRGFTAASDSDLLAQTHRSFSLDS 1206

  Fly  1189 L----QHLDKD------------VCCVASW---DSSM--HDSQALNRVTEANERVYLILRTTVRL 1232
            |    :.|.:|            :.....|   |||:  .|.:|:.|:...|      .||..||
Human  1207 LIDAEEELGEDQQEEPFPGSADEIPTETFWHLEDSSLPVMDQEAICRLGPIN------YRTAARL 1265

  Fly  1233 SHPAPM--------------------DLVLRKRLSINIKKGQT--------LTDRLKKFRLVRGE 1269
            ....||                    :|.....|..:.::.::        ..|.|:..:|.| |
Human  1266 DAVLPMSSSFYLDPQFQPHCELQPHCELQPHCELQPHCEQAESQVEPSYSEQADSLQGMQLSR-E 1329

  Fly  1270 NAIWQSGVTYEVVSNIPKAS-------------------------------EELE--DRESL--- 1298
            :.:......:...|.|..:|                               |||:  |.|::   
Human  1330 SPLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQEFHSCKGERPGYWPNTEELKPSDAETVLPY 1394

  Fly  1299 -AQLAASGDD--CSASDGETYIEKYTRGVSAVE----SILTLDRLRQNVA--------VKEL--- 1345
             ::|.....:  |||.|..|        .||.:    |:..:.||.|..|        :.::   
Human  1395 SSKLHQGSTELLCSARDEHT--------ASAADTSRLSLWGIQRLIQPGADGTFQGRCIPDMTQQ 1451

  Fly  1346 ---ETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPA- 1406
               |.:|..        ||.|.     ..||..:|.:||   |..:.:.|||..|:......|. 
Human  1452 GSSEASHNS--------SVSNV-----LAASATTLTHVG---STHERDWSALQQKYLLELSCPVL 1500

  Fly  1407 GAGGVIRSRHSF-----GGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPE 1466
            .|.|..:..:.:     |....:....|.......|..|..|.:....:|   |...|.|..|.|
Human  1501 EAIGAPKPAYPYLEEDSGSLAQASSKGGDTLLPVGPRVSSNLNLNNFPVH---LSRIRRLRAEKE 1562

  Fly  1467 ------------DSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTS 1519
                        |.:|.||..|.|::              |.|..::|            ||.:.
Human  1563 QDSLNAKLEGVSDFFSTSEKEASYDE--------------TYSADLES------------LSASR 1601

  Fly  1520 SANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNR 1584
            |.||.:.........||:.:..       |..||| .|.:.|.|...:..:.|.|....|:   .
Human  1602 STNAQVFATENAIPDSMTEACE-------VKQNNL-EECLQSCRKPGLMTSSDEDFFQKNA---C 1655

  Fly  1585 QARVNPFLK----DMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNN 1645
            .:.|....|    ....|.:::....|..:|.....:|||  |...:.|....|..:  ::.|.:
Human  1656 HSNVTTATKADHWSQGWAPLRKNSAVQPGQLSPDSHYPLE--EEKTDCQESSKEAVR--RHINVS 1716

  Fly  1646 LDLVNEPK---------PLSSQTDLEESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGI 1701
            ..|.:.|:         ||||      |:..|..:|.:.|      :|.|.|:.::         
Human  1717 FALPSGPELYLHSAPWNPLSS------SLQPPLLETFYVT------KSRDALTETA--------- 1760

  Fly  1702 VREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQA------PRI--NHRASVAKMEGLAAYLD 1758
              .|:||.:.||   ..:.||.......:|:.....|      |.:  |..:.:|..:.:.|.:.
Human  1761 --LEIPACREVR---VPSPPPREAWGFGHNHQALQGAYLKNNLPVLLQNQNSKIASSQQVTAEIP 1820

  Fly  1759 SSIMTSST---------EVDEESKD 1774
            ..:.|...         .:.|||.|
Human  1821 VDLNTREVIRESGKCPGNITEESHD 1845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 178/395 (45%)
KISc 6..359 CDD:214526 178/395 (45%)
Kinesin_assoc 356..468 CDD:292801 27/118 (23%)
FHA 446..546 CDD:238017 34/99 (34%)
KIF1B 741..786 CDD:289208 9/46 (20%)
DUF3694 <1196..1252 CDD:289256 16/80 (20%)
CAP_GLY 1786..1850 CDD:279625
STARD9XP_011520133.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.