Protein Alignment Khc-73 and kif13ba

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_005169924.1
• Gene: kif13ba / 571520
• ZFINID: ZDB-GENE-070521-1
• Length: 1822
• Species: Danio rerio
• Alignment Length: 1965
• Identity: 894/1965 - (45%)
• Similarity: 1183/1965 - (60%)
• Gaps: 239/1965 - (12%)

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLN-PEDEN 69
            :||||||||.||||.:|:|||:||||..||.|.:....:...|.||||||:|:||:|:: .|.|.
Zfish    11 VKVAVRVRPMNRREKDLNTKCVVEMEGNQTFLYSTNLGKDSSRGQPKTFAYDYCFWSMDESETEK 75

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANK 134
            ||.|:.||.|:|..:|.||||||||||||||||||||||||||:.:..|:|||||..||......
Zfish    76 FAGQDVVFQCLGESLLHNAFQGYNACIFAYGQTGSGKSYTMMGSVDQPGLIPRLCSSLFERTVLH 140

  Fly   135 STPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMT 199
            ...|..:.|||||||||||||.||||||.::|:|:||||.|:||||||||:|||.||:||::||:
Zfish   141 QREEESFTVEVSYMEIYNEKVRDLLDPKGSRQALRVREHKVLGPYVDGLSRLAVESYKDIESLMS 205

  Fly   200 EGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAVG 264
            ||||||||||||||.|||||||||:::||..|.|..:|.||||||::|||||||||||.||||.|
Zfish   206 EGNKSRTVAATNMNEESSRSHAVFNIILTHTLKDLQSGTSGEKVSKLSLVDLAGSERAAKTGAAG 270

  Fly   265 DRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATI 329
            :||||||||||||||||||||.||||..||  ..:||||||||||||||||:|||||||.||||:
Zfish   271 ERLKEGSNINKSLTTLGLVISALADQGAGK--NKNKFVPYRDSVLTWLLKDSLGGNSRTAMVATV 333

  Fly   330 SPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVGDVQD 394
            ||:||||:|||||||||||||.||||||||||||||||||||.|||.||..|..|......::::
Zfish   334 SPAADNYDETLSTLRYADRAKSIVNHAVVNEDPNARIIRELREEVEKLRDQLTQAESMKAPELKE 398

  Fly   395 KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLN 459
            :|.|||.|:::::.||||||.|||.|..|||:.||.:|||:|:|||||.::|.:||||||||:||
Zfish   399 RLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGEDKCFLVNLNADPALN 463

  Fly   460 ELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSG-LYMEPVQGARCFVNGSAAV 523
            ||||||||:.|.:|    |....||||.|:|||.|||||.|...| :::.|.:.:|..||||...
Zfish   464 ELLVYYLKEHTKVG----SADSQDIQLCGMGIQAEHCVINITPEGAVFINPYRNSRTCVNGSPVT 524

  Fly   524 EKTPLQNGDRILWGNHHFFRVNSPK-----------------SNNTSMCASEPQTPAQL-----I 566
            .:..|.:||||||||:||||:|.||                 ||:......|..|.:::     .
Zfish   525 SRQQLHHGDRILWGNNHFFRINLPKRRLRGEEEEGEGGNMKSSNSNEQLDGEGDTASEVSSEVSF 589

  Fly   567 DYNFARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSP------ 624
            .|.||:.|:|...| ||||:|..:..|||||||:|:.|||:||..||::.||||..|:|
Zfish   590 SYEFAQTEVMMKALGSNDPMQAVLQSLERQHEEEKRTALERQRLMYEQELQQLRRQLTPDRQSMQ 654

  Fly   625 ---STPYAP-YAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEA 685
               |.|..| |...:.|..|.:: ::.::|.|:.:|::||:.:..|||.:|:..|:|||.|||||
Zfish   655 IPQSQPLQPHYRSMERLSQGGMS-SSSSAQHRLRQWSEEREVVLTRSLRKLREQIVRANLLVQEA 718

  Fly   686 NFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMRE 750
            :|:|||::|:|::.||||||.|||:.||:|.|.:|||||.|:|...|.|||.:||:||:|:||||
Zfish   719 SFIAEELDKRTEYRVTLQIPAANLNANRKRDAVLSEPAIQVRRKGKGKQIWALEKMENRLVDMRE 783

  Fly   751 MYQEHKERVLNGLDEDNA------KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQ 809
            :|||.|:     .||||:      |..|||::.|.||:||||||:||..||:||||.|..|||:|
Zfish   784 LYQEWKD-----FDEDNSVMRSYFKRADPFFDEQVNHSLIGVANVFLSCLFYDVKLQYAVPIINQ 843

  Fly   810 QGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLS 874
            :|||||||.||:.|:.|....       |...|:..|...|. |....::.|.:.|..|:|||..
Zfish   844 KGEVAGRLHVEVMRMGGGFDD-------SVGGGEESDGSPDG-DVQERKLVCMIKILQATGLPQY 900

  Fly   875 LSNFVFCQYTFWGHQE--MVVPVINAE---STAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGAL 934
            |||||||||:||...|  :|.|.::..   |::.|.:.:..|:..::..|.:.|||:|:..|||:
Zfish   901 LSNFVFCQYSFWDQAEPIIVAPEVDPSASFSSSKDPHCMVVFDSLKEHAVNVTEEFIEYLTEGAV 965

  Fly   935 SIEVWGHRSAGFSKTKG-WEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNR 998
            .|||:|||.|...:... |::...|||.|:|.|||:|::||:|:||:|.|||:||||.||||...
Zfish   966 GIEVYGHRQADPGRNPALWDLSIIQAKTRTLRDRWSEVTRKLEMWVQILELNENGEYMPVEVVPA 1030

  Fly   999 NEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVR-------SRLQRP-- 1054
            .:|.||||:||:|||.|||.|.|:.||:|||:|:|.:.|:.|:||.|.:|       :..|.|
Zfish  1031 RDVRTGGIFQLKQGQSRRVQVEVRSVQDSGTMPLISEIILGVSIGCVQIRQVPMTKNNEPQEPEG 1095

  Fly  1055 --LDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERN 1117
              :|||||.||..||.:|..||.:|::||||.:|.|:.|.:|:|.:.|||..|:...::||||||
Zfish  1096 DEMDSYQERDLERLRHQWLTALTKRQEYLDQHLQTLVSKSDKSEDDVEREAQLLEGRLTLTEERN 1160

  Fly  1118 AVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHK 1182
            ||:||:.|||||||||.|.|..|||.|:|||||:|:.||.|:|...|.....|.::.||.|...:
Zfish  1161 AVMVPSAGSGIPGAPAEWVPVPGMETHIPVLFLDLSADDFSSQENLDVPEAGGWDATLSSEDEDE 1225

  Fly  1183 FYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLS 1247
            |:.|||::|.|.:|...|||||::|:.|.|:|...|::|||||:||.|:|||||.|.||||||:.
Zfish  1226 FFDLQIVKHYDGEVKAEASWDSTVHECQQLSRGATADQRVYLIVRTVVQLSHPAEMQLVLRKRIC 1290

  Fly  1248 INIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIP-KASEELEDRESLAQLAASGDDCSAS 1311
            :||...|......  .|.:...:.|...|||:||||||| :.|:..||||.||::|||.::..:|
Zfish  1291 VNITGRQGFAQNF--LRRMSTRSTIPGCGVTFEVVSNIPGQDSQSSEDREMLARVAASAENPKSS 1353

  Fly  1312 DGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQI--MRFDASM 1374
            |.|..||||.|.|.|||:|||||||||.|||||.....|:  ..|:::|.|:..::  .|.|.|:
Zfish  1354 DNEAAIEKYLRSVLAVENILTLDRLRQEVAVKEHLAGKGK--GSRRSLSSPSVHRLSGSRQDLSL 1416

  Fly  1375 ESLL--NVGRSESFADLNNSALG-NKFTPAGHSPAGAGGVIRS-RHSFGGKGSSDDSPGKAFGIA 1435
            .|:|  |..|.||..|:..::.| :|..|....|.......:. ...|.|..:|..||.||.
Zfish  1417 NSVLDDNKNRWESQQDIFATSSGFSKTLPRPSRPPTPPTQSQDPEQGFSGLAASYISPVKAL--- 1478

  Fly  1436 SPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSMAT-------RSR 1493
            .|...|||........|:     :.|...|            :.|:......|.|       |.|
Zfish  1479 VPQMPKLLKSLFPVRDEK-----KDLRPSP------------HSQQHMPRIMMQTANNPDEGRVR 1526

  Fly  1494 LTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNED 1558
            :.....|........||:      ...|.::| |......||..|..||||.|.:||...||:..
Zfish  1527 IEPVAVMGKSPSSDRHSD------APDAPSSM-HDPHDLPLSPISEASSGYFSTSVSTATLSDVS 1584

  Fly  1559 IASMRSMSIDETPDFDRVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLE 1623
            ||..     |.||         .||.|                                 |..:.
Zfish  1585 IACG-----DLTP---------TPNTQ---------------------------------LGSVA 1602

  Fly  1624 SSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRSSDE- 1687
            |.|..: |.:||...|.|              :|...:|..:...:.|.|.|. ::||..:|.:
Zfish  1603 SRQRGE-DSEECLATPVN--------------ASIAPVEAGIRSDRHKHEEAA-HRNGVTTSQQE 1651

  Fly  1688 --------LSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHR 1744
                    ||.|:::......:...||       |..||.....:|.:..|
Zfish  1652 AQLQTNPVLSTSTDNPFSLQKVKANEL-------RSFSNILGDGDGKATTN-------------- 1695

  Fly  1745 ASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQ 1809
             .:.|:|             .|..|.|.|::     .|:.||..|.:.. :.||.:|::|.|.|.
Zfish  1696 -ILEKLE-------------ITFEDAEPKEL-----AWLKVGGRVTVGT-SKSGTVRYIGPTHFS 1740

  Fly  1810 PGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKAAEKSNSISKE 1874
            .|.|:|||||||:|||||||:|.|||:|.|..|:.||.|:|   .|.:|.:.:....:|...|::
Zfish  1741 EGVWVGVELDTPSGKNDGSVEGHQYFRCNPGFGVLVRPDRL---SRREASKRHNENRRSGEFSQQ 1802

  Fly  1875 MSTSMTGSMTRSKSR 1889
            :......::.::::|
Zfish  1803 LRGGTGTAIQKAENR 1817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	250/353 (71%)
		Kinesin_assoc	356..468	CDD:465047	70/111 (63%)
		FHA_KIF13	446..547	CDD:438758	57/101 (56%)
		KIF1B	741..786	CDD:463574	24/50 (48%)
		DUF3694	989..1243	CDD:463599	135/264 (51%)
		CAP_GLY	1785..1850	CDD:460154	35/64 (55%)
kif13ba	XP_005169924.1	KISc_KIF1A_KIF1B	9..363	CDD:276816	250/353 (71%)
		Kinesin_assoc	360..472	CDD:465047	70/111 (63%)
		FHA_KIF13B	450..548	CDD:438782	57/101 (56%)
		KIF1B	774..820	CDD:463574	24/50 (48%)
		DUF3694	1021..>1084	CDD:463599	34/62 (55%)
		bMERB_dom	<1102..1161	CDD:463467	28/58 (48%)
		DUF3694	<1239..1296	CDD:463599	33/56 (59%)
		CAP_GLY	1717..1781	CDD:460154	35/64 (55%)