DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif13ba

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_005169924.1	Gene:	kif13ba / 571520	ZFINID:	ZDB-GENE-070521-1	Length:	1822	Species:	Danio rerio

Alignment Length:	1965	Identity:	894/1965 - (45%)
Similarity:	1183/1965 - (60%)	Gaps:	239/1965 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLN-PEDEN 69
            :||||||||.||||.:|:|||:||||..||.|.:....:...|.||||||:|:||:|:: .|.|.
Zfish    11 VKVAVRVRPMNRREKDLNTKCVVEMEGNQTFLYSTNLGKDSSRGQPKTFAYDYCFWSMDESETEK 75

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANK 134
            ||.|:.||.|:|..:|.||||||||||||||||||||||||||:.:..|:|||||..||......
Zfish    76 FAGQDVVFQCLGESLLHNAFQGYNACIFAYGQTGSGKSYTMMGSVDQPGLIPRLCSSLFERTVLH 140

  Fly   135 STPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMT 199
            ...|..:.|||||||||||||.||||||.::|:|:||||.|:||||||||:|||.||:||::||:
Zfish   141 QREEESFTVEVSYMEIYNEKVRDLLDPKGSRQALRVREHKVLGPYVDGLSRLAVESYKDIESLMS 205

  Fly   200 EGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAVG 264
            ||||||||||||||.|||||||||:::||..|.|..:|.||||||::|||||||||||.||||.|
Zfish   206 EGNKSRTVAATNMNEESSRSHAVFNIILTHTLKDLQSGTSGEKVSKLSLVDLAGSERAAKTGAAG 270

  Fly   265 DRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATI 329
            :||||||||||||||||||||.||||..||  ..:||||||||||||||||:|||||||.||||:
Zfish   271 ERLKEGSNINKSLTTLGLVISALADQGAGK--NKNKFVPYRDSVLTWLLKDSLGGNSRTAMVATV 333

  Fly   330 SPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVGDVQD 394
            ||:||||:|||||||||||||.||||||||||||||||||||.|||.||..|..|......::::
Zfish   334 SPAADNYDETLSTLRYADRAKSIVNHAVVNEDPNARIIRELREEVEKLRDQLTQAESMKAPELKE 398

  Fly   395 KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLN 459
            :|.|||.|:::::.||||||.|||.|..|||:.||.:|||:|:|||||.::|.:||||||||:||
Zfish   399 RLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGEDKCFLVNLNADPALN 463

  Fly   460 ELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSG-LYMEPVQGARCFVNGSAAV 523
            ||||||||:.|.:|    |....||||.|:|||.|||||.|...| :::.|.:.:|..||||...
Zfish   464 ELLVYYLKEHTKVG----SADSQDIQLCGMGIQAEHCVINITPEGAVFINPYRNSRTCVNGSPVT 524

  Fly   524 EKTPLQNGDRILWGNHHFFRVNSPK-----------------SNNTSMCASEPQTPAQL-----I 566
            .:..|.:||||||||:||||:|.||                 ||:......|..|.:::     .
Zfish   525 SRQQLHHGDRILWGNNHFFRINLPKRRLRGEEEEGEGGNMKSSNSNEQLDGEGDTASEVSSEVSF 589

  Fly   567 DYNFARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSP------ 624
            .|.||:.|:|...| ||||:|..:..|||||||:|:.|||:||..||::.||||..|:|
Zfish   590 SYEFAQTEVMMKALGSNDPMQAVLQSLERQHEEEKRTALERQRLMYEQELQQLRRQLTPDRQSMQ 654

  Fly   625 ---STPYAP-YAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEA 685
               |.|..| |...:.|..|.:: ::.::|.|:.:|::||:.:..|||.:|:..|:|||.|||||
Zfish   655 IPQSQPLQPHYRSMERLSQGGMS-SSSSAQHRLRQWSEEREVVLTRSLRKLREQIVRANLLVQEA 718

  Fly   686 NFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMRE 750
            :|:|||::|:|::.||||||.|||:.||:|.|.:|||||.|:|...|.|||.:||:||:|:||||
Zfish   719 SFIAEELDKRTEYRVTLQIPAANLNANRKRDAVLSEPAIQVRRKGKGKQIWALEKMENRLVDMRE 783

  Fly   751 MYQEHKERVLNGLDEDNA------KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQ 809
            :|||.|:     .||||:      |..|||::.|.||:||||||:||..||:||||.|..|||:|
Zfish   784 LYQEWKD-----FDEDNSVMRSYFKRADPFFDEQVNHSLIGVANVFLSCLFYDVKLQYAVPIINQ 843

  Fly   810 QGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLS 874
            :|||||||.||:.|:.|....       |...|:..|...|. |....::.|.:.|..|:|||..
Zfish   844 KGEVAGRLHVEVMRMGGGFDD-------SVGGGEESDGSPDG-DVQERKLVCMIKILQATGLPQY 900

  Fly   875 LSNFVFCQYTFWGHQE--MVVPVINAE---STAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGAL 934
            |||||||||:||...|  :|.|.::..   |::.|.:.:..|:..::..|.:.|||:|:..|||:
Zfish   901 LSNFVFCQYSFWDQAEPIIVAPEVDPSASFSSSKDPHCMVVFDSLKEHAVNVTEEFIEYLTEGAV 965

  Fly   935 SIEVWGHRSAGFSKTKG-WEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNR 998
            .|||:|||.|...:... |::...|||.|:|.|||:|::||:|:||:|.|||:||||.||||...
Zfish   966 GIEVYGHRQADPGRNPALWDLSIIQAKTRTLRDRWSEVTRKLEMWVQILELNENGEYMPVEVVPA 1030

  Fly   999 NEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVR-------SRLQRP-- 1054
            .:|.||||:||:|||.|||.|.|:.||:|||:|:|.:.|:.|:||.|.:|       :..|.|
Zfish  1031 RDVRTGGIFQLKQGQSRRVQVEVRSVQDSGTMPLISEIILGVSIGCVQIRQVPMTKNNEPQEPEG 1095

  Fly  1055 --LDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERN 1117
              :|||||.||..||.:|..||.:|::||||.:|.|:.|.:|:|.:.|||..|:...::||||||
Zfish  1096 DEMDSYQERDLERLRHQWLTALTKRQEYLDQHLQTLVSKSDKSEDDVEREAQLLEGRLTLTEERN 1160

  Fly  1118 AVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHK 1182
            ||:||:.|||||||||.|.|..|||.|:|||||:|:.||.|:|...|.....|.::.||.|...:
Zfish  1161 AVMVPSAGSGIPGAPAEWVPVPGMETHIPVLFLDLSADDFSSQENLDVPEAGGWDATLSSEDEDE 1225

  Fly  1183 FYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLS 1247
            |:.|||::|.|.:|...|||||::|:.|.|:|...|::|||||:||.|:|||||.|.||||||:.
Zfish  1226 FFDLQIVKHYDGEVKAEASWDSTVHECQQLSRGATADQRVYLIVRTVVQLSHPAEMQLVLRKRIC 1290

  Fly  1248 INIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIP-KASEELEDRESLAQLAASGDDCSAS 1311
            :||...|......  .|.:...:.|...|||:||||||| :.|:..||||.||::|||.::..:|
Zfish  1291 VNITGRQGFAQNF--LRRMSTRSTIPGCGVTFEVVSNIPGQDSQSSEDREMLARVAASAENPKSS 1353

  Fly  1312 DGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQI--MRFDASM 1374
            |.|..||||.|.|.|||:|||||||||.|||||.....|:  ..|:::|.|:..::  .|.|.|:
Zfish  1354 DNEAAIEKYLRSVLAVENILTLDRLRQEVAVKEHLAGKGK--GSRRSLSSPSVHRLSGSRQDLSL 1416

  Fly  1375 ESLL--NVGRSESFADLNNSALG-NKFTPAGHSPAGAGGVIRS-RHSFGGKGSSDDSPGKAFGIA 1435
            .|:|  |..|.||..|:..::.| :|..|....|.......:. ...|.|..:|..||.||.
Zfish  1417 NSVLDDNKNRWESQQDIFATSSGFSKTLPRPSRPPTPPTQSQDPEQGFSGLAASYISPVKAL--- 1478

  Fly  1436 SPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSMAT-------RSR 1493
            .|...|||........|:     :.|...|            :.|:......|.|       |.|
Zfish  1479 VPQMPKLLKSLFPVRDEK-----KDLRPSP------------HSQQHMPRIMMQTANNPDEGRVR 1526

  Fly  1494 LTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNED 1558
            :.....|........||:      ...|.::| |......||..|..||||.|.:||...||:..
Zfish  1527 IEPVAVMGKSPSSDRHSD------APDAPSSM-HDPHDLPLSPISEASSGYFSTSVSTATLSDVS 1584

  Fly  1559 IASMRSMSIDETPDFDRVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLE 1623
            ||..     |.||         .||.|                                 |..:.
Zfish  1585 IACG-----DLTP---------TPNTQ---------------------------------LGSVA 1602

  Fly  1624 SSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRSSDE- 1687
            |.|..: |.:||...|.|              :|...:|..:...:.|.|.|. ::||..:|.:
Zfish  1603 SRQRGE-DSEECLATPVN--------------ASIAPVEAGIRSDRHKHEEAA-HRNGVTTSQQE 1651

  Fly  1688 --------LSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHR 1744
                    ||.|:::......:...||       |..||.....:|.:..|
Zfish  1652 AQLQTNPVLSTSTDNPFSLQKVKANEL-------RSFSNILGDGDGKATTN-------------- 1695

  Fly  1745 ASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQ 1809
             .:.|:|             .|..|.|.|::     .|:.||..|.:.. :.||.:|::|.|.|.
Zfish  1696 -ILEKLE-------------ITFEDAEPKEL-----AWLKVGGRVTVGT-SKSGTVRYIGPTHFS 1740

  Fly  1810 PGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKAAEKSNSISKE 1874
            .|.|:|||||||:|||||||:|.|||:|.|..|:.||.|:|   .|.:|.:.:....:|...|::
Zfish  1741 EGVWVGVELDTPSGKNDGSVEGHQYFRCNPGFGVLVRPDRL---SRREASKRHNENRRSGEFSQQ 1802

  Fly  1875 MSTSMTGSMTRSKSR 1889
            :......::.::::|
Zfish  1803 LRGGTGTAIQKAENR 1817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	250/353 (71%)
		KISc	6..359	CDD:214526	250/353 (71%)
		Kinesin_assoc	356..468	CDD:292801	70/111 (63%)
		FHA	446..546	CDD:238017	56/100 (56%)
		KIF1B	741..786	CDD:289208	24/50 (48%)
		DUF3694	<1196..1252	CDD:289256	33/55 (60%)
		CAP_GLY	1786..1850	CDD:279625	34/63 (54%)
kif13ba	XP_005169924.1	KISc_KIF1A_KIF1B	9..363	CDD:276816	250/353 (71%)
		KISc	10..363	CDD:214526	250/353 (71%)
		Kinesin_assoc	360..472	CDD:292801	70/111 (63%)
		FHA	450..547	CDD:238017	56/100 (56%)
		KIF1B	774..820	CDD:289208	24/50 (48%)
		DUF3585	<1100..1161	CDD:304905	30/60 (50%)
		DUF3694	<1239..1297	CDD:289256	33/57 (58%)
		CAP_GLY	1718..1781	CDD:279625	34/63 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	476	1.000	Domainoid score	I409
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9073
Inparanoid	1	1.050	1564	1.000	Inparanoid score	I87
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		otm26193
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.880