DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Khc-73 and kif1ab

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:XP_009296795.1 Gene:kif1ab / 566766 ZFINID:ZDB-GENE-070912-480 Length:1799 Species:Danio rerio


Alignment Length:1958 Identity:559/1958 - (28%)
Similarity:829/1958 - (42%) Gaps:635/1958 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQP---KTFAFDHCFYS 62
            ||...:||||||||||.|||..|:|||::|....|.:.||        |||   |:|.||:.::|
Zfish     1 MAGASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTILNP--------KQPKENKSFNFDYSYWS 57

  Fly    63 -LNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLC 124
             ..|||.|:|.|:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||.||
Zfish    58 HTTPEDVNYACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQEGIIPLLC 122

  Fly   125 DQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVT 189
            :.||:.|.:.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.:|||||:.||:||||
Zfish   123 EDLFTKINDNNDNNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLMGPYVEDLSKLAVT 186

  Fly   190 SYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGS 254
            ||.||.:||..|||:|||||||||..||||||||:::.||...|..:..:.||||::||||||||
Zfish   187 SYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLAGS 251

  Fly   255 ERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLAD-----QSNGKKSGNDKFVPYRDSVLTWLLK 314
            |||..|||.|.|||||:||||||||||.|||.||:     ..|.||...:.|:|||||||||||:
Zfish   252 ERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSAPNKNKKKKKVESFIPYRDSVLTWLLR 316

  Fly   315 DNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRS 379
            :||||||||.|||.:||:..||:|||||||||||||:|..:||:|||||.|::|||:.||..|:.
Zfish   317 ENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLVRELKEEVARLKD 381

  Fly   380 MLKHATG-----------------------------------------------SPVGDVQ---- 393
            :| :|.|                                               |.||.:.    
Zfish   382 LL-YAQGLGDIIENLSNYKANISSIQAVNQRGDFSTVTNAMTGMSPSPSLSALTSRVGSISSLHD 445

  Fly   394 ------------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKV---- 442
                        ::|.|:|.::.::::||||||.:||.|:.||:..|.:||::::..|..|    
Zfish   446 RIMFSPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTVGVFS 510

  Fly   443 EKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVIT-----IED 502
            .|...:|||||.||.::|.|:||:||.....||..:..:.||.|||..|:.|||:.|     |.:
Zfish   511 PKKTPHLVNLNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDEHCIFTSTTNAIGE 575

  Fly   503 SGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSMCASEPQTPA 563
            ..:.:||.:||..:|||....|.|.|::|:||:.|..|.||.|.|    :....:.||   .||.
Zfish   576 GTVVLEPCEGAETYVNGKRVTEPTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPCA---DTPV 637

  Fly   564 QLIDYNFARDEIMQNE--LSNDPIQTAIARLERQHEEDKQVA---LEKQRQEYERQFQQLRNILS 623
            :.:|:.||:.|:::.:  .....:...:..||.|:.::::.|   ||:||.:||.:.:.|:..::
Zfish   638 EPVDWAFAQRELLEKQGIDMKQEMDQRLQELEDQYRKEREEASNLLEQQRLDYESKLEALQKQVN 702

  Fly   624 PSTPYAPYAPYDPLRMGKITPNTPTSQMRVE---KWAQERDEM----FRR-------SLGQLKTD 674
                            .:..|.|...:..:|   .|.:...|:    ||:       ||    .|
Zfish   703 ----------------SRYYPETTEEEEELEDEVPWTKRETELALWAFRKWRFYQFTSL----RD 747

  Fly   675 IMRANSL-VQEANFLAEEMEKKTKFSVTL-------QIPPANLSP----NRRRGAFVSEPAILV- 726
            ::..|:: ::|||.::.|::||.:|...|       .:||..|.|    :|.:..|   |..:| 
Zfish   748 LLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPSIAKDREKRLF---PRTIVA 809

  Fly   727 ----KRTNSGSQIWTMEKLENKLIDMREMYQ---------------------------------- 753
                .:.|..:..||::||..:|..|||||.                                  
Zfish   810 VEVQDQKNGATHYWTLDKLRQRLDLMREMYDRAAEVPSTAVEDCDHIMSGGDPFYDRFPWFRLVG 874

  Fly   754 -----------------------------------------EHKERVLNGLD-----EDNAKP-- 770
                                                     |.:|..|..||     |||...  
Zfish   875 RTPILNTCMSERMSGLTLSPTLSDPDSDITELADERHYGKVEVEEEELEDLDDEIFVEDNGSELG 939

  Fly   771 ---------------------QDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVA 814
                                 |||||:.....:|:|.|.::|..|.:.|.|.:...|:|::|||.
Zfish   940 REEEEDDDDGVGERCPGVSDGQDPFYDRWPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVK 1004

  Fly   815 GRLQVEIERIAG--QMP------------------------QDRMCES-------------VSES 840
            |.|:|.::.|:.  :.|                        |...|.|             :.|.
Zfish  1005 GFLRVAVQAISADEEAPDYGSGVRQSGTAKISFEDQAFEKFQTEACTSGMSQTHTSEEELRIVEG 1069

  Fly   841 SGD------SRDEYDD--------------------PVDPTSNQ----------ITCRVTIKCAS 869
            .|.      |.||.::                    |:|.|.::          .|.|||:..||
Zfish  1070 EGQNSELGLSADEVNNNTCLVSPDISDSPLKGVLECPLDVTQDKSLQHLKIGSNFTFRVTVLQAS 1134

  Fly   870 GLPLSLSNFVFCQYTF-WGHQEMVVPVINAESTAHDQNM----VFKFEHTQDFTVTINEEFLEHC 929
            .:....:: :|||:.| ..|.|       |.||...:|.    ...|.|.|:.||.:.:.|:|:.
Zfish  1135 SISAEYAD-IFCQFNFIHRHDE-------AFSTEPLKNTGRGPPLGFYHVQNITVEVTKSFVEYI 1191

  Fly   930 IEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSR--------------------- 973
            ....:..||:||          ::.:......:.|:.....:.|                     
Zfish  1192 KSQPIVFEVFGH----------YQKQPFPPLCKDLISSLRPMRRQFPRVMPLSKPVPATKLSTLA 1246

  Fly   974 ---------KIEL--WVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNS 1027
                     |.:|  :.||.||..||:|.|..|.:|..:...|.:.|.||.|||:.|.:  ...:
Zfish  1247 RSTAGPCHCKYDLMAFFEICELEANGDYIPAVVDHRGGMPCHGTFLLHQGIQRRITVTI--AHET 1309

  Fly  1028 GTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKE 1092
            |                                .|:     :|.|            ::.|:...
Zfish  1310 G--------------------------------NDI-----EWKE------------VKELVIGR 1325

  Fly  1093 EKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDL 1157
            .:|..|.:..:                                     ::|:  :|.||:...:.
Zfish  1326 IRNTPEADETI-------------------------------------IDPN--ILSLNILSSNY 1351

  Fly  1158 SAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERV 1222
            .....:|.:|       |..:| ..||..:            |:||||||:|..|||||...|::
Zfish  1352 IRPTYDDRVS-------LGSDH-RTFYRFE------------AAWDSSMHNSLLLNRVTPYGEKI 1396

  Fly  1223 YLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPK 1287
            |:.|...:.:.:.....:|.:....:...:..    :|...|.:|.   ::.:|....:.||...
Zfish  1397 YITLSAYLEMENCTQPTVVTKDFCMVFYSRDA----KLPASRSIRN---LFSTGAFRPLESNCVT 1454

  Fly  1288 ASEELEDRESLAQLAASGD-----------DCSASDGETYIEKYTRGVSAVESILTLDRLRQNVA 1341
            ...||    ||..||..|.           |.|.:        |.||    |..|...|.|.:..
Zfish  1455 GVYEL----SLCHLADIGSPGMQRRRRRVLDTSVA--------YVRG----EENLAGWRPRSDSL 1503

  Fly  1342 VK----ELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFA-DLNNSALGNKFTPA 1401
            :.    |||     .||:.:.|.......::|  ..:|:.|.:|:...:. ||.:|       |.
Zfish  1504 ILDHQWELE-----KLSLLQEVEKTRHYLLLR--EKLEASLLLGQDSFYGKDLLDS-------PK 1554

  Fly  1402 GHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPE 1466
            .:||.                   .||..:.|:.||                             
Zfish  1555 ANSPM-------------------ISPVMSLGLDSP----------------------------- 1571

  Fly  1467 DSYSDSEYAAEYEQERQQNKSMATRS-RLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTG 1530
                         .|||  :.:|.:. ||........:..|||..::|.||..|::.......:.
Zfish  1572 -------------NERQ--RELAAKCVRLLMHTFNRQYSQVSSSLSESKLSEISASLLRDSVTSP 1621

  Fly  1531 LATLSMSSSTSS---GYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFL 1592
            |::|:.||:..|   |:.|          .|:....:.|...:||.|..   ||..|:.|...|:
Zfish  1622 LSSLTPSSTCPSLLDGHYS----------TDLRGAEANSGASSPDLDPF---SPIERKPRTCTFI 1673

  Fly  1593 KDMPKAKI 1600
            .::.:.::
Zfish  1674 PNIQEIRV 1681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 220/365 (60%)
KISc 6..359 CDD:214526 220/363 (61%)
Kinesin_assoc 356..468 CDD:292801 51/178 (29%)
FHA 446..546 CDD:238017 43/104 (41%)
KIF1B 741..786 CDD:289208 21/147 (14%)
DUF3694 <1196..1252 CDD:289256 17/55 (31%)
CAP_GLY 1786..1850 CDD:279625
kif1abXP_009296795.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 220/365 (60%)
KISc 5..361 CDD:214526 220/364 (60%)
Kinesin_assoc 358..538 CDD:292801 53/180 (29%)
FHA 515..618 CDD:238017 43/102 (42%)
ATP-synt_B <647..696 CDD:304375 11/48 (23%)
KIF1B 828..874 CDD:289208 7/45 (16%)
DUF3694 1320..1428 CDD:289256 30/166 (18%)
PH_KIFIA_KIFIB 1680..1782 CDD:269939 0/2 (0%)
PH 1685..1778 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.850

Return to query results.
Submit another query.