Protein Alignment Khc-73 and kif14

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_005170522.2
• Gene: kif14 / 562052
• ZFINID: ZDB-GENE-030131-5759
• Length: 1506
• Species: Danio rerio
• Alignment Length: 1220
• Identity: 374/1220 - (30%)
• Similarity: 589/1220 - (48%)
• Gaps: 246/1220 - (20%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNP 65
            |.:..:.||||||||:.||.......::.||.|.|::|:|      :.||...|.||..|.|:|.
Zfish   231 MENSAVTVAVRVRPFSSREKNEKACQVIFMENQDTLVQHP------DTKQTHKFTFDFSFCSINE 289

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSA 130
            .|.:|:||:.:::.:.|.:|:.||.|:|.|:||||||||||||||||..|..|:|||.|::|||.
Zfish   290 ADASFSSQQLIYEKLARPLLERAFDGFNTCLFAYGQTGSGKSYTMMGFGEETGVIPRFCEELFSR 354

  Fly   131 IANKSTPELMYKVEVSYMEIYNEKVHDLL----DPKPNKQSLKVREHNVMGPYVDGLSQLAVTSY 191
            :|...|.|:...:|:||.|:||||:||||    :....|..|:||||.|.||||..||...|:||
Zfish   355 LARSETKEMSCHLEMSYFEVYNEKIHDLLVAKDEQNQKKMPLRVREHPVYGPYVADLSTNVVSSY 419

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEK-----VSRMSLVDL 251
            .||...:..|||.|..|||.||.:|||||:||::|:||..|:   .|..|:     .||::||||
Zfish   420 SDIKTWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTE---FVEEEEHDHCITSRINLVDL 481

  Fly   252 AGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDN 316
            |||||.......||||:||::|||||.|||.|||.|::||..:|.   .|.|||:||||||||::
Zfish   482 AGSERCTSAQTSGDRLREGASINKSLLTLGKVISSLSEQSQSRKK---VFTPYRESVLTWLLKES 543

  Fly   317 LGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML 381
            |||||:|.|:||:||:|.|.||:|||||||.:|:.|:|.|.||||.||::||:|:.|||.||:..
Zfish   544 LGGNSKTAMIATLSPAASNMEESLSTLRYAQQARMIINIAKVNEDTNAKLIRDLKAEVEKLRAAQ 608

  Fly   382 KHATG----------SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQ 436
            ..:.|          ..:..:::||.:.|:.|.:..:||:|||.:.||.:.|..:.|::.|::
Zfish   609 MSSQGVEPEKMRLFQQEIAALKNKLCQQEHEMAEAHRTWKEKLEEAERRKREEAKELQRAGVT-- 671

  Fly   437 ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIE 501
               .||:.....|||||.||.|:|:|:|.:|:.....|:..|....||||||..|..:||||:..
Zfish   672 ---FKVDNRLPNLVNLNEDPQLSEMLLYMIKEGQTKVGKLKSESAHDIQLSGALIADQHCVISSV 733

  Fly   502 DSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP---KSNNTSMCASEPQTPA 563
            ...:.::|:..|:.||||....|.|.|.:|||::.|..|:||.|.|   :|...:.|.|......
Zfish   734 KGTVSIKPMPNAKTFVNGHLVSECTVLHHGDRVILGGDHYFRFNHPAEVQSGKRASCWSSGDGHK 798

  Fly   564 QLIDYNFARDEIM---------------------------------QNELSNDP--IQTAIARLE 593
               |:.||::|::                                 |.|||...  .:..|..||
Zfish   799 ---DFEFAKNELLSAQRAQLEAEIQEARLKAKEEMMQGIQVAKEMAQKELSEQKSLYEIKIRALE 860

  Fly   594 RQHEEDKQVALEKQ--RQEYERQFQQLRNI----------------LSPSTPYAPYAPYDPLRMG 640
            |:.:|:.:...|::  :|....|.:||:::                :.........|.:| :|..
Zfish   861 RELKEESERKREQELHKQRAASQIEQLQSVKTLLEKEVSSHKRRLQMEAQATRQAMADHD-VRHA 924

  Fly   641 KITPNTPTSQMRV-EKWAQERDEMFRRSLGQLKT--------DIMRANSLVQEANFLAEEMEKKT 696
            ||.......:.:: |..||  .|| :|:|...:|        |.|:.:.:::|||.::.::.|.|
Zfish   925 KIVAALEAEKRKIAEDLAQ--IEM-KRALKVTQTPKMAIPQWDAMKLSLMIEEANKISGKLRKHT 986

  Fly   697 KFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSG-SQIWTMEKLENKLIDMREMYQEHKERVL 760
            .||       .:.:.::......::..:.|:.|..| |..|::||.::.|..|||:.|
Zfish   987 VFS-------RHEAADKEVEGGDAQLQVQVQNTKLGISTFWSLEKFQSNLAAMREIEQ------- 1037

  Fly   761 NGLDEDNAKPQDPFYESQE-------------------NHNLI---GVANIFLEVLFHDVKLDYH 803
               .|..:|..|.||:..:                   :.:|:   .::....|:..|.::..:.
Zfish  1038 ---GESASKDDDVFYDPNDEWEPDLSASSSTSSFSRRRSRSLLKSRRISGRLYEIRVHPIQSLHC 1099

  Fly   804 TPIISQQ---------------------------GEVAGRLQV-----EIERIAGQMPQDRMCES 836
            ||  ||.                           |....||:.     |.|.:|.::..|.:  |
Zfish  1100 TP--SQSTGLMNKPPSLHSSTSDSALPGICKDLIGSAVARLRSCQSADESESLADKLTLDLL--S 1160

  Fly   837 VSESSGDSRDEYDD-PVDPTSNQITCRV-----TIKCASGLPLS-------LSNFVFCQYT---- 884
            |..:.....|.|:| ..|...|...|..     .:|..|.:..:       :|:..|...|
Zfish  1161 VHRAVRSITDLYEDLDDDSEENLFACSTEAQTHLVKATSAVERAVFITMHWVSSITFGSITVSQR 1225

  Fly   885 ----------FWGHQEMVVPVINAE----------STAHDQNMVFK------------FEHTQDF 917
                      ..|:.::::...::|          ..|...|.|||            ....:..
Zfish  1226 AEELKMEVKKIGGYLQLLIQGCDSEISSMVTEARKRVAECINAVFKTIGFLAAVNGTDLHLNEQN 1290

  Fly   918 TVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSL-VDRWAELSRKIELWVE- 980
            :.||:...:..|::..:...|....|.|...|:  |:.|......:| :.:|.:::|.::.::.
Zfish  1291 SETIDNRSVVDCLQDGMRQSVKDLLSVGLLVTE--EMLQVSHTGSTLQISKWMDVARSLQNYLRC 1353

  Fly   981 -IHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQR--RVNVRVKPVQNS 1027
             :.:.:|:.|...|:..:.|      :|.::....:  ::|..:|.:.:|
Zfish  1354 CLSKSSDSSENHCVDYESSN------LYDIQSTTTKLLKLNQAIKDLHSS 1397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	185/363 (51%)
		Kinesin_assoc	356..468	CDD:465047	43/121 (36%)
		FHA_KIF13	446..547	CDD:438758	42/100 (42%)
		KIF1B	741..786	CDD:463574	11/66 (17%)
		DUF3694	989..1243	CDD:463599	7/41 (17%)
		CAP_GLY	1785..1850	CDD:460154
kif14	XP_005170522.2	None