DRSC/TRiP Functional Genomics Resources

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Protein Alignment Khc-73 and KIF16B

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:XP_005260807.1 Gene:KIF16B / 55614 HGNCID:15869 Length:1883 Species:Homo sapiens


Alignment Length:1778 Identity:494/1778 - (27%)
Similarity:767/1778 - (43%) Gaps:431/1778 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE-------RKQPKTFAFDH 58
            |||  :||||||||.||||.:|:.|.|::|||.:|.:.|   |:..|       |::.|||.:|.
Human     1 MAS--VKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITN---LKIPEGGTGDSGRERTKTFTYDF 60

  Fly    59 CFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRL 123
            .|||.:.:..::.|||.||..:|..::.:||:|||||:||||||||||||||||.....|:|||:
Human    61 SFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRI 125

  Fly   124 CDQLFSAIANKST--PELMYKVEVSYMEIYNEKVHDLLDPKPNKQ-SLKVREHNVMGPYVDGLSQ 185
            |:.|||.| |::|  .|..::.||||:|||||:|.|||..|.:|. :|:||||...||||:.||:
Human   126 CEGLFSRI-NETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSK 189

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            ..|.:|.|::.||..||.:||.|||.||..||||||:|::..||...|  :.:..|.||::.|||
Human   190 HLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFD--SEMPCETVSKIHLVD 252

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQS----NGKKSGNDKFVPYRDSVLTW 311
            |||||||..|||.|.|||||.||||||.|||.|||.|||.|    |........|||||||||||
Human   253 LAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTW 317

  Fly   312 LLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVET 376
            ||||:|||||:|:|:|||||:..||.|||||||||:|||.|:|...:|||.|.::|||||.|:..
Human   318 LLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIAR 382

  Fly   377 LRSMLKHATGSPVG--------DVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGI 433
            |:::|  |.|:.:.        .:::||.::|..::::::.|..|..:|:.|..|:..||.|.||
Human   383 LKTLL--AQGNQIALLDSPTALSMEEKLQQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGI 445

  Fly   434 SVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVI 498
                 |:.::....:|:.::.|.....:::|:||:.....||..:..:.||.|.||.::.|||:.
Human   446 -----GVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHCIF 505

  Fly   499 TIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKS-------------- 549
            ......:.:.|:.|::|.|||...||.|.|..|..||.|..:.||.|.||.              
Human   506 ENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLS 570

  Fly   550 ----NNTSMCASEPQTPAQLIDYN---------------FARDEIMQNELSN-DPIQTAIARLER 594
                :.|.:..|.....|.:: ||               |.|.:  :.||.. :..:..|..:|.
Human   571 SFSLSMTDLSKSRENLSAVML-YNPGLFPIKGPICLRLEFERQQ--REELEKLESKRKLIEEMEE 632

  Fly   595 QHEEDK------QVALEKQRQEYE---------------RQF---QQLRNILSPSTPYAPYAPYD 635
            :.:.||      |..:|.||:|.|               |.|   .:|:::|:....:..    :
Human   633 KQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEE----E 693

  Fly   636 PLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSV 700
            .||        ...::.::|..||.:...|     ::.::.|...|        ...||..||.:
Human   694 RLR--------EQQEIELQKKRQEEETFLR-----VQEELQRLKEL--------NNNEKAEKFQI 737

  Fly   701 TLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQ----------EH 755
            ..::.......:.:......|...|.::..  .|:..:..||.:|.:.:||.|          |.
Human   738 FQELDQLQKEKDEQYAKLELEKKRLEEQEK--EQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEE 800

  Fly   756 KERVLNGL--------------DEDN---AKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYH 803
            ::|.|.|:              |||.   .|.|..|:|. :...|:.:.|:..:::   .:.|..
Human   801 EKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEF-KRRQLVKLVNLEKDLV---QQKDIL 861

  Fly   804 TPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDD-----PVD---------- 853
            ...:.::.|:...|:.|.::      :.|:.|...||..|..:...|     ||:          
Human   862 KKEVQEEQEILECLKCEHDK------ESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQL 920

  Fly   854 --------PTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFK 910
                    ||..:...|.......| ||||.|.::........:|..:....|.:     |.:.|
Human   921 QYLLQNHLPTLLEEKQRAFEILDRG-PLSLDNTLYQVEKEMEEKEEQLAQYQANA-----NQLQK 979

  Fly   911 FEHTQDFTVTI----------NEEFLE-------HCIEGALSIEVWGHRSAGFSKTKGWEVEQQQ 958
            .:.|.:||..|          .:|.||       ..:|.||:.....|.:.....|.|.|:|:|:
Human   980 LQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQR 1044

  Fly   959 AKARSLVDRWAELS-RKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVK 1022
            .|..||.....|.| .:..|..|...|..:.|....|:    :.|...||:: .|.|:..:..::
Human  1045 QKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEI----QQLKQKIYEV-DGVQKDHHGTLE 1104

  Fly  1023 PVQNSGTLPIICQS-----IVNVAIGSVTVRSRLQRPL-------------------DSYQEEDL 1063
            ....|.:||:..:.     :::..|.:. :...:||.|                   |:.:..:.
Human  1105 GKVASSSLPVSAEKSHLVPLMDARINAY-IEEEVQRRLQDLHRVISEGCSTSADTMKDNEKLHNG 1168

  Fly  1064 TVLREKWSEALGRRRQ-----YLDQQI-------QMLIKKEEKN--------------------- 1095
            |:.|:...|    :||     |||..:       ..|||:|.:.                     
Human  1169 TIQRKLKYE----KRQFCPAWYLDPLLPRDATDTSSLIKEERREVDQNDHWDHPMLWSVSGPKTT 1229

  Fly  1096 ---EQER---ERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLN-LN 1153
               .|||   :|:.|.|.:....:|.:         .|.|.....:||.....|.:.  ||| .|
Human  1230 SSASQERTHQQRDQSSVPEVFQDSENK---------YGHPEHAGHFEPKCFNLPKIS--FLNESN 1283

  Fly  1154 GDDL-SAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCV-ASWDSSMHDSQALNRVT 1216
            .||. ..|:.::..|                   :::.|.||....| :||....|.||.::..:
Human  1284 TDDAEDFQSQSENFS-------------------ELMTHKDKHGLRVKSSWTLLQHTSQEVSINS 1329

  Fly  1217 ---EANERVYLILRTTVRLSH------PAPMDLVLRKRLS-------INIKKGQTLTDRLKKFRL 1265
               :|.:...|.|..:..:||      .||..::..:..|       ::.|| .:.::.|...| 
Human  1330 GGKQARQGKVLCLVLSEGISHEERASCSAPQSVLASEFYSEQQGEEELDAKK-MSSSESLVNIR- 1392

  Fly  1266 VRGENAIWQSGVTYEVVSNIPK--ASEELE-DRESLAQLAASGDDCSASDGETYIEKYTRGVSAV 1327
            ..|.|.:   |..|...|::.|  :|..|: ..:.::|....|:.|:.....:.:..:.|     
Human  1393 TEGNNGL---GYFYHKFSDLYKDTSSHLLQAGTKVISQARLVGNLCAPRGLPSQVTTFVR----- 1449

  Fly  1328 ESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNS 1392
             |:..|..|..::.:|         ..|:.|.|           .|.|:  .||.|||      .
Human  1450 -SLPFLKHLAPHMPLK---------TDMQSTES-----------HSPEA--RVGSSES------E 1485

  Fly  1393 ALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGG 1457
            |.|:.....|.:|..|.       .|...|....||...|.:                       
Human  1486 AAGSLRPAEGAAPYRAS-------VFAATGLPGSSPSSVFRL----------------------- 1520

  Fly  1458 HRSLDEEPEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSA- 1521
                               |||..|   ||.|.:..|.  :..|..:.:.....:..|.:.:.: 
Human  1521 -------------------EYEDAR---KSSAFKQSLV--QFPDQMLKLQECPLKDLLRHVTCSL 1561

  Fly  1522 ---NANMKHLTGLATLSMSSSTS 1541
               ..|||.:.|:..|::::.|:
Human  1562 PEPLGNMKEVKGIYWLAVAACTA 1584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 203/368 (55%)
KISc 6..359 CDD:214526 203/366 (55%)
Kinesin_assoc 356..468 CDD:292801 32/119 (27%)
FHA 446..546 CDD:238017 31/99 (31%)
KIF1B 741..786 CDD:289208 18/71 (25%)
DUF3694 <1196..1252 CDD:289256 14/72 (19%)
CAP_GLY 1786..1850 CDD:279625
KIF16BXP_005260807.1 KISc_KIF1A_KIF1B 2..365 CDD:276816 205/370 (55%)
KISc 3..365 CDD:214526 204/369 (55%)
Kinesin_assoc 364..476 CDD:292801 33/118 (28%)
FHA 478..543 CDD:278899 22/64 (34%)
TPH 610..934 CDD:290579 65/362 (18%)
GBP_C <618..818 CDD:303769 39/226 (17%)
coiled coil 808..818 CDD:293879 0/9 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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