DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and kif3a

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001017604.2	Gene:	kif3a / 550267	ZFINID:	ZDB-GENE-050417-71	Length:	701	Species:	Danio rerio

Alignment Length:	508	Identity:	201/508 - (39%)
Similarity:	285/508 - (56%)	Gaps:	74/508 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEK-QQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPE 66
            ||.:||.||.||.|.:|..:..|..|.::: :.||..|  .|: |..:.||||.||..|   .|:
Zfish    15 SDNVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITVN--KLD-ISSEPPKTFTFDTVF---GPD 73

  Fly    67 DENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQ---ESKGIIPRLCDQLF 128
                :.|..|::...|.|:|:..:|||..||||||||:||::||.|.:   |.:||||.....:|
Zfish    74 ----SKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGIIPNSFAHVF 134

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            ..|| |:..:..:.|.|||:|||||:|.|||. |...|.|:|:|...:|.|:..||...|.:..|
Zfish   135 GHIA-KAEGDTRFLVRVSYLEIYNEEVRDLLG-KDQMQRLEVKERPDVGVYIKDLSGYVVNNADD 197

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE---KVSRMSLVDLAGSE 255
            :|.:||.|:|:|:|.|||||..||||||:|::.    :.....||.|.   ::.::.||||||||
Zfish   198 MDRIMTLGHKNRSVGATNMNEHSSRSHAIFTIT----IECSEKGVDGNQHVRMGKLHLVDLAGSE 258

  Fly   256 RAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGN 320
            |..||||.|.||||.:.||.||:|||.|||.|.|       |....||||:|.||.||:|:||||
Zfish   259 RQGKTGATGQRLKEATKINLSLSTLGNVISALVD-------GKSTHVPYRNSKLTRLLQDSLGGN 316

  Fly   321 SRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH-- 383
            |:|:|.|.|.|:..||:||:||||||:|||.|.|.|.:||||...::|:.:.|:|.|:..|:.
Zfish   317 SKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGE 381

  Fly   384 ------ATGS------PVGD--------------VQDKLAESENLMKQISQTWEEKLVKTERIQN 422
                  .:||      .|||              ..||:.|.:..:::..:..|.||...|..:|
Zfish   382 EISGSDGSGSDDMDEDDVGDGGERRRKRRGRKKVSPDKMVEMQAKIEEERKALEAKLDMEEEERN 446

  Fly   423 ERQQALEKMGISVQASGIKVEKNKYYLV-NLNADPSLNELLVYYLKDRTLIGG 474
            :.:..|||.    :...:|.::..:.|: .|:|           |:.|.::||
Zfish   447 KARAELEKR----EKDLLKAQQEHHLLLEKLSA-----------LEKRVIVGG 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	167/361 (46%)
		KISc	6..359	CDD:214526	166/359 (46%)
		Kinesin_assoc	356..468	CDD:292801	31/140 (22%)
		FHA	446..546	CDD:238017	7/30 (23%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	164/354 (46%)
kif3a	NP_001017604.2	Kinesin	23..348	CDD:278646	160/347 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910