DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KIF1A

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001366560.1	Gene:	KIF1A / 547	HGNCID:	888	Length:	1816	Species:	Homo sapiens

Alignment Length:	1992	Identity:	574/1992 - (28%)
Similarity:	824/1992 - (41%)	Gaps:	669/1992 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.||:..|:|||::|....|.:.||    |..::.||:|:||:.::| .:
Human     1 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNP----KQPKETPKSFSFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            |||.|:|||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||:||:.|
Human    62 PEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.|.:.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
Human   127 FSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYN 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||:::.||...|..|.::.||||::|||||||||||
Human   191 DIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNG----KKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..:|    ||.....|:|||||||||||::|||
Human   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||||.|||.:||:..||:|||||||||||||:|..:||:|||||.::||||:.||..||.:| :
Human   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLL-Y 384

  Fly   384 ATGSPVGDVQD------------------------------------------------------ 394
            |.|  :||:.|
Human   385 AQG--LGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSSR 447

  Fly   395 ----------------------KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQA 437
                                  :|.|:|.::.::::||||||.:||.|:.||:..|.:||::::.
Human   448 AASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMRE 512

  Fly   438 S----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVI 498
            .    |:...|...:|||||.||.::|.|:||:||.....||....::.||.|||..|:.||||.
Human   513 DGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCVF 577

  Fly   499 TIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSM 554
            ..:..|     :.:||.:||..:|||....|.:.|::|:||:.|..|.||.|.|    :....:.
Human   578 RSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTP 642

  Fly   555 CASEPQTPAQLIDYNFARDEIMQNE--LSNDPIQTAIARLERQHEEDKQVA---LEKQRQEYERQ 614
            ||   :|||:.:|:.||:.|:::.:  .....::..:..||.|:..:::.|   ||:||.:||.:
Human   643 CA---ETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESK 704

  Fly   615 FQQLRNILS----PSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEM----FRR----- 666
            .:.|:..:.    |........|.|.:                 :|.:...|:    ||:
Human   705 LEALQKQMDSRYYPEVNEEEEEPEDEV-----------------QWTERECELALWAFRKWKWYQ 752

  Fly   667 --SLGQLKTDIMRANSL-VQEANFLAEEMEKKTKFSVTL-------QIPPANLSP----NRRRGA 717
              ||    .|::..|:: ::|||.::.|::||.:|...|       .:||..|.|    :|....
Human   753 FTSL----RDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRP 813

  Fly   718 FVSEPAILV-----KRTNSGSQIWTMEKLENKLIDMREMYQ----------EHKERVLNGLD--- 764
            |   |..:|     .:.|..:..||:|||..:|..|||||.          |..:.|:.|.|
Human   814 F---PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFY 875

  Fly   765 ----------------------------------------------------------------- 764

Human   876 DRFPWFRLVGSSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATEPAEEQSVGEEEEEEEE 940

  Fly   765 ---------EDNAKPQ-------DPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEV 813
                     ||:..|:       ||||:.....:|:|.|.::|..|.:.|.|.:...|:|::|||
Human   941 EEDEEEEDLEDDVFPEHALCDGRDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEV 1005

  Fly   814 AGRLQVEIERIAG--QMP------------------------QDRMCESVSES-SGDSRDE---- 847
            .|.|:|.::.|:.  :.|                        |...|..|..| ||.|::|
Human  1006 KGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIV 1070

  Fly   848 --------------------------------------YDDPVDPT------SNQITCRVTIKCA 868
                                                  .|.|:|..      .|..|.|||:..|
Human  1071 EGQGQGADVGPSADEVNNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQA 1135

  Fly   869 SGLPLSLSNFVFCQYTF-WGHQEMVVPVINAESTAHDQNM----VFKFEHTQDFTVTINEEFLEH 928
            |.:....:: :|||:.| ..|.|       |.||...:|.    ...|.|.|:..|.:.:.|:|:
Human  1136 SSISAEYAD-IFCQFNFIHRHDE-------AFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEY 1192

  Fly   929 CIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIE----------------- 976
            .....:..||:||...........:|......:|....|...||:.:.
Human  1193 IKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHC 1257

  Fly   977 -----LWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQS 1036
                 ::.||.||..||:|.|..|.:|..:...|.:.|.||.|||:.|
Human  1258 KYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITV----------------- 1305

  Fly  1037 IVNVAIGSVTVRSRLQRPLDSYQEEDLTVLRE-----KWSEALGRRRQYLDQQIQMLIKKEEKNE 1096
                                       |:|.|     :|.|            ::.|:....:|.
Human  1306 ---------------------------TLLHETGSHIRWKE------------VRELVVGRIRNT 1331

  Fly  1097 QERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQN 1161
            .|.:..|                                     ::|::    |:||
Human  1332 PETDESL-------------------------------------IDPNI----LSLN-------- 1347

  Fly  1162 TNDELSVAGINSILSKEHGH------KFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANE 1220
                        |||..:.|      .||..:            |:||||||:|..|||||...|
Human  1348 ------------ILSSGYIHPAQDDRTFYQFE------------AAWDSSMHNSLLLNRVTPYRE 1388

  Fly  1221 RVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNI 1285
            ::|:.|...:.:.:.....:|.:....:...:..    :|...|.:|.   ::.||......||.
Human  1389 KIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDA----KLPASRSIRN---LFGSGSLRASESNR 1446

  Fly  1286 PKASEELEDRESLAQLAASGD-----------DCSASDGETYIEKYTRGVSAVESILTLDRLRQN 1339
            .....||    ||..:|.:|.           |.|.:        |.||    |..|...|.|.:
Human  1447 VTGVYEL----SLCHVADAGSPGMQRRRRRVLDTSVA--------YVRG----EENLAGWRPRSD 1495

  Fly  1340 VAVK----ELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTP 1400
            ..:.    |||     .||:.:.|.......::|     |.|....|.               .|
Human  1496 SLILDHQWELE-----KLSLLQEVEKTRHYLLLR-----EKLETAQRP---------------VP 1535

  Fly  1401 AGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEP 1465
            ...|||      .|..|.....||..||..|.|..||
Human  1536 EALSPA------FSEDSESHGSSSASSPLSAEGRPSP---------------------------- 1566

  Fly  1466 EDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMD---SFMDVS-SHSNQSYLSYTSSANANMK 1526
                      .|...|||:..::.....||.:...:   |.:.|| |.|..|.:|.|...:.:|.
Human  1567 ----------LEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMS 1621

  Fly  1527 HLTGLATLSMSSSTSS----GYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQAR 1587
            .| |:|||:.||:..|    .||:..:                   .||        .|.:|.|.
Human  1622 PL-GVATLTPSSTCPSLVEGRYGATDL-------------------RTP--------QPCSRPAS 1658

  Fly  1588 VNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQ 1629
            ..|.|          .||..:|||..    |....|:.:..|
Human  1659 PEPEL----------LPEADSKKLPS----PARATETDKEPQ 1686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	220/361 (61%)
		KISc	6..359	CDD:214526	220/359 (61%)
		Kinesin_assoc	356..468	CDD:292801	51/191 (27%)
		FHA	446..546	CDD:238017	42/104 (40%)
		KIF1B	741..786	CDD:289208	19/138 (14%)
		DUF3694	<1196..1252	CDD:289256	17/55 (31%)
		CAP_GLY	1786..1850	CDD:279625
KIF1A	NP_001366560.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820