DRSC/TRiP Functional Genomics Resources

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Protein Alignment Khc-73 and cmet

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster


Alignment Length:2360 Identity:502/2360 - (21%)
Similarity:837/2360 - (35%) Gaps:787/2360 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPED 67
            :..|:|.::|||     .|.....:.:::::::|        .:.....:.:.||:.|      |
  Fly     6 ASSIQVCIKVRP-----CEPGLTSLWQVKERRSI--------HLADSHAEPYVFDYVF------D 51

  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132
            |..::|| |||.:.:.|:....||:|..|||||||.|||:|||||.:::.|::.....::|..|:
  Fly    52 EGASNQE-VFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQIS 115

  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREH-----NVMGPYVDGLSQLAVTSYQ 192
            :::  |..:.:.|.|:||||||::|||:.|  .|.||:.|.     ||      ...:..:||..
  Fly   116 SET--ERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESGNGIVNV------NCEECIITSEV 170

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKV--SRMSLVDLAGSE 255
            |:..|:..|||.|||..||||..||||||:|.:::....:|.:   ..:.|  |.::||||||||
  Fly   171 DLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHS---DDDAVIQSVLNLVDLAGSE 232

  Fly   256 RAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGN 320
            ||.:|||.|.|||||.:|||||..|..||..|::      :.:::|..||||.||.:|:.:||||
  Fly   233 RADQTGARGARLKEGGHINKSLLFLSNVIKSLSE------NADNRFTNYRDSKLTRILQASLGGN 291

  Fly   321 SRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNE-DPNARIIRELRHEVETLRSMLKHA 384
            :.|.::.||.||.  .||:.|||.:|.|||:|.....||| ..:|.:::.|..|::.|:      
  Fly   292 AFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLK------ 348

  Fly   385 TGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYL 449
                     |||||.|.                   :||.||.:|.:     ...||.:.:|   
  Fly   349 ---------DKLAEEER-------------------KNENQQKVEHL-----ERQIKHDMHK--- 377

  Fly   450 VNLNADPSLNELLVYYLKDRTLIGGRTIS--GQQ------------PDIQLSGLGIQPEHCVITI 500
                                 :|.|.::|  |||            ..::|:..|        |.
  Fly   378 ---------------------IICGHSLSDKGQQKRRRTWCPTASGSHLELAETG--------TT 413

  Fly   501 ED--------SGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNN------ 551
            ||        |.| .:||     |.:.|.|        |.|  |.       |.||:.|      
  Fly   414 EDRIDQFPKVSHL-PKPV-----FFHTSNA--------GKR--WD-------NIPKTINILGSLD 455

  Fly   552 ---TSMCASEPQTPAQLIDYNFARDEIMQNELS-----------NDPIQTAIARLERQHEEDKQV 602
               .|...||...||:.||:...|.::::..|:           ..|:.|...:.|.|   |.|:
  Fly   456 IGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQ---DLQM 517

  Fly   603 --ALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFR 665
              :|||..:....:.|.|:..|:..|     |..|.|....:          .||   ||.:...
  Fly   518 FTSLEKHFEVECEEVQGLKEKLAEVT-----AQRDNLEQESL----------AEK---ERYDALE 564

  Fly   666 RSLGQLKTDIMRANSLVQEANFLAE------------EMEKKTKFSVTLQIPPANLSPNRRRGAF 718
            :.:..|:.|...|||.:.|   |.|            |:|.:....:..:......|...|....
  Fly   565 KEVTSLRADNEAANSKISE---LEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDL 626

  Fly   719 VSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNL 783
            :|  |:|.|.:       |:|.|:..|                    ||. .:|....|:|.|.|
  Fly   627 LS--ALLEKES-------TIESLQKSL--------------------DNL-TRDVLRNSKEGHML 661

  Fly   784 IGVANIFLEVLFHDVKLDYHTPIISQQGEVAG----RLQVEIERIAGQMPQDR---MCESVSESS 841
                                 .|..:|.::||    ....|:|::...:...:   .|:.:....
  Fly   662 ---------------------SIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEI 705

  Fly   842 GDSRDEYDDPVDPTSNQITCRVTIKCAS----GLPLSLSNFVFCQY--------TFWGHQEMVVP 894
            ...||:.:. |:...|..:..:..|...    ...||.|...|.|.        ..|..|:..: 
  Fly   706 VSVRDKLES-VESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGI- 768

  Fly   895 VINAESTAHDQNMVFKFEHTQDFTVTINEEF--LEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQ 957
                 :|.|:     |.||.|:....:.||:  ||.....|.|.|        |.:.:. :..:.
  Fly   769 -----TTLHE-----KHEHVQEKYQKLQEEYEQLESRARSASSAE--------FQRLQN-DNTKF 814

  Fly   958 QAKARSLVDRWAELSRKI------------------ELWVEIHELNDNGEYSP----------VE 994
            ||...||.:|..|....:                  ||..:|.||..|.|...          :|
  Fly   815 QADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLME 879

  Fly   995 VTNRNEVL-----------------TGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAI 1042
            ....|:.|                 :.||......|::.:|:..:.||       :.:|:..:.:
  Fly   880 SVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQ-------LSESVQQIEL 937

  Fly  1043 GSVTVRSRL----QRPLD-------------SYQEEDLTVLREKWSEA----------------- 1073
            ...:..|||    |..||             .|.|||     .:.|:|                 
  Fly   938 QHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEED-----NRQSDATEPICLKGFLKRHRFQI 997

  Fly  1074 ---------LGRRRQYLD--QQIQMLIKKE------------EKNEQERERELSLVHQWVSLT-- 1113
                     :|..::.||  .|::..|:::            |..||....|.:|:.:.|.:.  
  Fly   998 KRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKV 1062

  Fly  1114 ----------EERNAVL-----------------------VPAPGSGIPGAPASWEPPSGMEPHV 1145
                      |::||.:                       ||.....:||.|.|   ||..|..|
  Fly  1063 EDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTS---PSRREQEV 1124

  Fly  1146 PVLFLNLNG-----DDLSAQNTND----ELSVAGINSILS--KEHGHKFYTLQI-LQHLDKDVCC 1198
            ..|..::..     .||.|:..|.    :|....|..:.:  :|...:..:::: |..||:|   
  Fly  1125 ATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDED--- 1186

  Fly  1199 VASWDSSMHDSQA---------LNRVTEANERV---YLILRTTVRLSHPAPMDLVLRKRLSINIK 1251
             ......:.|.||         ::::.:.|.::   |.....::.|:...|..::|..:....|:
  Fly  1187 -TKQKQELLDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIE 1250

  Fly  1252 K-GQTLT---DRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASD 1312
            | .|.|.   |.|...|.::.:..   |.:..|.:..|     |..::|:.|:..|...:..   
  Fly  1251 KLNQLLNAAKDELHDVRRIKDDEI---SALRMEFLLQI-----ETNEKENQAKFYAELQETK--- 1304

  Fly  1313 GETYIEKYTRGVSAV-ESILTLDRLRQNVAVK---ELE---TAHGQPLS---------------- 1354
                 ::|...|:.: |.:|.::....:|.|:   |||   :||.:.:|                
  Fly  1305 -----DRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAE 1364

  Fly  1355 ---MRKTVS---------------------------------------VPNFSQIMRFDASMESL 1377
               :|:|:.                                       ....|::.....::|.:
  Fly  1365 METIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKGASKLEEVKKTLEQM 1429

  Fly  1378 LNVGR--SESFADLNNSALG-----NKFTPAG----------HSPAGAGGVIRSRHSFGGKGSSD 1425
            :|.||  |::.|:|..:...     ||.|...          ........:.|.:.||     ..
  Fly  1430 INGGRVMSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISF-----EI 1489

  Fly  1426 DSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDE--------EPEDSYSDSEYAAEYEQER 1482
            ::..|...:...::.|    |:..|.|:.......||:        |.|...::||::...|:.:
  Fly  1490 EAHIKKLELIVASSKK----RIIELEEKCDQQVLELDKCRLEKLSLESEIQKANSEHSCTMEKLQ 1550

  Fly  1483 QQNKSMATRSRLTASKTMD----------SFMD------------------VSSHSN-QSYLSYT 1518
            :....|...|.....:..|          ...|                  ||.|.. :..|:..
  Fly  1551 ELQAEMKVLSNRNEKEKCDFETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLKICLAEA 1615

  Fly  1519 SSANANM-KHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPP 1582
            :..::|: |.:..|.|..:.|  ..|..|:.|..|.|..|..|:|.:.:.........|..    
  Fly  1616 NELSSNLQKKVMSLHTELIDS--QKGISSRDVEINELREELKAAMDAKATASAEQMTLVTQ---- 1674

  Fly  1583 NRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQN---------------AQSDD 1632
                     |||     ::|:...||:|    ||.....|:.|.|               .:|.:
  Fly  1675 ---------LKD-----VEERMANQAEK----FTREAANLKGSINELLLKLNSMQETKDMLESGN 1721

  Fly  1633 DECAQLPKNNNNNLDLVNEPKPL------------SSQTDLEESMSQPKSK-----TEFATDNQN 1680
            :|..:..:|:.|..::::|...:            .::|.||:.:...||:     ||...:.:.
  Fly  1722 EELKEQLRNSQNLRNMLDEESKMCISLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTKEVEL 1786

  Fly  1681 GNRSSDELSHSSEDL---LEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRIN 1742
            |.....||:...|:|   ||....:|.:|...|...:|           ::.||.....:...:.
  Fly  1787 GRNRIGELTKKCEELCSDLENSDQIRLDLQETKEQLKK-----------TLENNLGWQQKVDEVT 1840

  Fly  1743 HRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTE 1807
            ......:.:           ..|.||..|||..||:                           :|
  Fly  1841 RECEKLRFD-----------MQSKEVQNESKVQELI---------------------------SE 1867

  Fly  1808 FQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKAAEKSNSIS 1872
            .:       ||.:.....:.|      ||.: |..|......|:.|||....:...|    |.|.
  Fly  1868 CE-------ELRSTLKSKEAS------FQSE-KESMDRTISSLLEDKRNLEEKLCSA----NDIV 1914

  Fly  1873 KEMSTSMTG-----SMTRSKSRGDSLNLSARKXLYPKCS-HQLQR---WTNCRQSTVATSSQPAT 1928
            .::.|.:..     |:.|:.....|:...:.. ...:.| |..:|   |.:.|:..:.|......
  Fly  1915 AKLETEIAALRPRKSLDRNPVPRKSITFESEIRKNRRISVHDERRQSYWNDVREFGIMTDPVDNN 1979

  Fly  1929 CHRLRATSGAADANSHGKKC 1948
            |:       .|:.||..:.|
  Fly  1980 CN-------CAELNSKLQDC 1992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 137/361 (38%)
KISc 6..359 CDD:214526 137/359 (38%)
Kinesin_assoc 356..468 CDD:292801 21/112 (19%)
FHA 446..546 CDD:238017 22/121 (18%)
KIF1B 741..786 CDD:289208 9/44 (20%)
DUF3694 <1196..1252 CDD:289256 9/67 (13%)
CAP_GLY 1786..1850 CDD:279625 8/63 (13%)
cmetNP_524993.3 KISc 8..328 CDD:214526 137/360 (38%)
Motor_domain 8..321 CDD:277568 136/353 (39%)
Smc <680..1449 CDD:224117 144/824 (17%)
TMPIT 779..>867 CDD:285135 22/96 (23%)
Smc 1042..1910 CDD:224117 171/986 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45437760
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
32.870

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