DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Klp98A

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	1258	Identity:	376/1258 - (29%)
Similarity:	569/1258 - (45%)	Gaps:	255/1258 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE---RKQPKTFAFDHCFYSLNPED 67
            :||||||||||.|||::|.:.|:|||.::|.|.. |.|:.|.   |.....|.||:.::|.:.||
  Fly     4 LKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLK-PRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67

  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132
            .:||:||.|:..:|..::|.|::|||||:||||||||||::|||||..:.|:|||:|::||:.:.
  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARMR 132

  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNL 197
            ........|:...||:|||||:|.|||..:.....|:||||..:||||:.|||.||:.:.:|...
  Fly   133 VGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQEC 197

  Fly   198 MTEGNKSRTVAATNMNAESSRSHAVFSVVLTQ--ILTDQATGVSGEKVSRMSLVDLAGSERAVKT 260
            :..||..||.|:||||..||||||:|::...|  .:.|    :..|.||::.||||||||||..|
  Fly   198 IARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMND----MPSETVSKIHLVDLAGSERANAT 258

  Fly   261 GAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDK--------------FVPYRDSVLTW 311
            ||.|.|||||::|||||.|||.|||.||:|:.|..:.:..              ::|||||:|||
  Fly   259 GATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTW 323

  Fly   312 LLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVET 376
            ||||:|||||:|:|:|.:||:..||.|||||||||:|||.|:|...||||.|.::|||||.|:..
  Fly   324 LLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINK 388

  Fly   377 LRSMLKHATGS------PVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISV 435
            |:|||.....|      .:.|:|.|.|:.:.|.::.::.|:   |....:|.::...|.|.|:
  Fly   389 LKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWK---VAQSILQEQKSLGLRKSGV-- 448

  Fly   436 QASGIKVEKNKYYLVNLNADPSLNELLVYYLKD-RTLIGGRTISGQQPDIQLSGLGIQPEHCVIT 499
               |:.::....:|:.::.|.:.. :.:|.||: .|.||.......| ||:|:|.||:.:||.|.
  Fly   449 ---GVVLDSEMPHLIGIHNDVTTG-VTLYSLKEGETRIGSEDADVAQ-DIELAGDGIRAQHCSIF 508

  Fly   500 IEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----------------- 547
            ::...:.:.|...|:|:||.....|...:..||.||.|..:.||.|:|
  Fly   509 LKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDM 573

  Fly   548 ---------KSN--NTSMCASE--------------PQTPAQLIDYNFARDEIMQNELSNDPIQT 587
                     |.|  ..|:.:.|              ||.|....|... :||   |....|.|:.
  Fly   574 SRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPEL-QDE---NRKILDTIEN 634

  Fly   588 AIARL--ER-QHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTS 649
            |:.:|  || |..:..:..:.|..:|..|..|:               ..|.|::.........:
  Fly   635 ALKQLNVERVQMHDQYKTKVRKLTEELIRLEQE---------------EMDGLQLLNCREQELIA 684

  Fly   650 QMRVEKWAQERDEM-----------FRRSLGQLKTDIMR--ANSL--VQEANFLAE---EMEKKT 696
            :..:..|.:..:::           |:..|...|.|...  |..|  :|:...|.|   ::|:.|
  Fly   685 RKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGT 749

  Fly   697 KFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLN 761
            ..:..|.:..:: |.:.....|:.:   .|:|.|.     .:.||:.::.:        |||:||
  Fly   750 PLNDELLLQVSD-SLDLFAAQFIKD---TVRRNNE-----EIRKLDEQIAE--------KERILN 797

  Fly   762 GLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAG 826
            ......||..:...|.|..          ||.|    :|:              |.:.|.|..|.
  Fly   798 ASTTKIAKVDETMLEIQAQ----------LERL----RLE--------------RAESEAESQAM 834

  Fly   827 QMPQDRM---CESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGH 888
            :..:..|   ..:.|.|:..|.:|.|| |..:....||.......|.|.|..|..:     ..|.
  Fly   835 RAKKQNMKLQLGNKSMSTSTSTNEADD-VSKSDTYETCDTFHTAQSNLSLVSSPTI-----TEGQ 893

  Fly   889 QEMVVPVINAESTAHDQNMVFKFEHT-QDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGW 952
            |.   |:.|....|.|:     .|.| :|.....:||....|..|..|....|....|.|.:...
  Fly   894 QS---PLSNCSCDAEDE-----AEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPS 950

  Fly   953 EVEQQQAKARSLVDRWAELSRKIELWVEIHELN-----------DNGEYSPVEVTNRNEVLTG-- 1004
            .....||   .:.|....|..:.:..::...||           |.|..|..|:...::|...
  Fly   951 CTPSSQA---IMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCSSCELGRHSDVARPYC 1012

  Fly  1005 GIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREK 1069
            .::.||:                           .:|.....:...|:..|:..|      |.|.
  Fly  1013 PLHSLRR---------------------------KIAAQKALIMKNLETDLNKAQ------LDEH 1044

  Fly  1070 WSEALGRRRQYLDQQIQMLIK-----------KEEKNEQEREREL------SLVHQWVSLTEERN 1117
            .::....:|:|:..:.:||..           .:|::..||:.||      |.|....|:.|..:
  Fly  1045 IADLQDLQRRYIQMEQEMLQSVQDLEAHAQCCADERSGMERQYELASSIMRSSVMSPTSMEESTS 1109

  Fly  1118 AVLVPAPGSGIPGAPASWEPPSG 1140
            .:..|   |.....|:..|.|.|
  Fly  1110 QIYSP---SMTRSCPSMREFPEG 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	185/371 (50%)
		KISc	6..359	CDD:214526	185/371 (50%)
		Kinesin_assoc	356..468	CDD:292801	32/117 (27%)
		FHA	446..546	CDD:238017	31/100 (31%)
		KIF1B	741..786	CDD:289208	10/44 (23%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	185/371 (50%)
		KISc	3..371	CDD:214526	185/371 (50%)
		Kinesin_assoc	370..478	CDD:292801	33/116 (28%)
		FHA	456..555	CDD:238017	31/100 (31%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437716
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D6426at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950